Spinal Cord Injury
Facts and Figures About Spinal Cord Injury in USA
• There are an estimated 10,000 to 12,000 spinal cord injuries every year in
the United States.
• A quarter of a million Americans are currently living with spinal cord injuries.
• The cost of managing the care of spinal cord injury patients approaches $4
billion each year.
• 38.5 percent of all spinal cord injuries happen during car accidents. Almost
a quarter, 24.5 percent, are the result of injuries relating to violent
encounters, often involving guns and knifes. The rest are due to sporting
accidents, falls, and work-related accidents.
• 55 percent of spinal cord injury victims are between 16 and 30 years old.
• More than 80 percent of spinal cord injury patients are men
Source: Facts and Figures at a Glance, May 2001. National Spinal Cord
Injury Statistical Center.
South Korea, Park et al. (2005)
ไดมีการศึกษาการรักษาผูปวยที่เปนอัมพาตจํานวน 6 คน โดยการใชส
เต็มเซลลที่ไดมาจากไขกระดูกของผูปวยเอง รวมกับการฉีดยา GM-
CSF และติดตามผลการรักษา 6-18 เดือน พบวา 4 ใน 6 ปวยมี
การทํางานของระบบประสาทดีขึ้น 2 ระดับ (ASIA grade)
In South Korea, Park et al. (2005) evaluated the
therapeutic efficacy of combining autologous
BMSC transplantation, administered directly into
the spinal cord lesion site, with granulocyte macrophage-
colony stimulating factor (GM-CSF),
given subcutaneously, in six patients with complete
SCIs. At the 6- and 18-month follow-up periods,
four of the six patients showed neurological
improvements by two ASIA grade (from ASIA A
to ASIA C)
Progress in Brain Research, Vol. 161,2007
Mean conduction velocities calculated from the
somatosensory evoked potentials at week 0, 4 and 8
J. Vet. Sci. (2007), 8(3), 275–282
Basso, Beattie and Bresnahan (BBB) locomotor rating scale scores plotted against time. There
was no statistical significance in BBB scores from 1 to 3 weeks. Groups IV, III, and II scored
higher than those in group I from 4 to 7 weeks. From 8 to 9 weeks, there was significant
differences between groups IV > III and either III or II > I, but no significant difference between II
and III. From 10 to 12 weeks, there was a difference for group IV > III, III > II, and II > I. Sham = gap
filled with fibrin glue (group I); G = fibrin glue + subcutaneous granulocyte colony-stimulating
factor (G-CSF) injection (group II); N = fibrin glue + neuronal stem cells (group III); G+N = fibrin
glue + neuronal stem cells + subcutaneous G-CSF injection (group IV).
J Clin Neurosci (2008),
Hind limb functional assessment with the hind limb
motor function scale (Farooque et al., 2001; Table 1). Time
course of hind limb functional recovery