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COTI Overview

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A brief overview of Critical Outcome Technologies Inc. - a clinical stage biopharmaceutical company rapidly developing targeted therapeutics, with an initial focus in oncology.

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COTI Overview

  1. 1. WHAT IS CHEMSAS® ? • Computerized Hybrid Expert Molecular Structure Activity Screening (CHEMSAS) is a drug discovery and preclinical development engine using a core platform technology. • It uses machine learning software and proprietary algorithms in a novel and proprietary process. • CHEMSAS accelerates drug discovery and provides optimized lead compounds with a higher probability of clinical success. • There are six major stages of the CHEMSAS technology (Figure 1). Figure 1. A simplified representation of CHEMSAS. WHAT IS ROSALIND™ ? • ROSALIND is a smart data platform that evaluates a tumor’s specific gene mutation profile and identifies treatments most likely to restore normal cell signaling (Figure 2). • Tumors have millions of mutation profiles, which allow for thousands of drug combinations. The vast combinations of drugs are too much for any clinician to consider. • ROSALIND provides physicians with suggestions of treatment combinations most likely to be effective against the specific mutation profile of the tumor. Figure 2. A brief overview of ROSALIND. • Critical Outcome Technologies Inc. (COTI) is a clinical stage biotech company focused on the development of novel therapeutics for the treatment of cancers and other unmet medical needs. • COTI has a pipeline of internally developed compounds. It’s lead clinical candidate, COTI-2, is currently in an open label, multi-site Phase I trial in gynecological malignancies. It’s second lead clinical candidate, COTI-219, is currently in IND-enabling studies. • COTI’s CHEMSAS® platform is a computational high-throughput screening technology for molecule identification. • COTI’s ROSALIND™ technology is a genomics profiling platform for personalized oncology care. • COTI has offices in Ontario, Canada and in Boston, Massachusetts. Profile 1 23 4 5 6FINAL LIBRARY SELECTION SELECT THE TARGET CREATE THE SIMULATIONS DESIGN THE CANDIDATE LIBRARY PROFILE AND OPTIMIZE MEDICINAL CHEMISTRY OPTIMIZATION 3Months Genetic profile of individual’s tumor Mechanism of action of potential drug therapies Patient demographics and comorbidities Phenotypic model of the specific cancer Determination of restoration of normal cell signaling Synergistic combinations at optimal doses PREDICTIVE SIMULATION HUMAN CELLULAR SIGNALING NETWORK MODELING IN PUTS OUT PUTS CriticalOutcome.com
  2. 2. WHAT IS COTI-2? • COTI-2 is a novel small molecule discovered using our proprietary CHEMSAS discovery engine. • It is our most advanced lead currently in a multi-site Phase I clinical trial in gynecological cancers. • COTI-2 restores p53 function to a wide range of common p53 mutations and also acts as a negative modulator of the PI3K/AKT/mTOR pathway. • Mutations in p53 occur in 50% of all cancers. WHAT IS COTI-219? • COTI-219 is a novel small molecule discovered using our proprietary CHEMSAS discovery engine. • It is our next most advanced lead and is currently in IND-enabling studies. • COTI-219 inhibits the activation of KRAS and is highly efficacious in multiple human cancer cell lines. • Mutations in KRAS occur in 9-30% of all cancers. SCIENTIFIC ADVISORY BOARD • Dr. Gordon Mills, University of Texas, MD Anderson Cancer Center, Houston, TX. • Dr. Douglas Levine, NYU Langone Medical Center, New York, NY. • Dr. David Parkinson, New Enterprise Associates, Menlo Park, CA. • Dr. Marshall Strome, Center for Head and Neck Oncology at Roosevelt St. Luke’s Hospital, New York, NY. • Dr. Nancy Chang, Apex Enterprise Inc., Houston, TX. • Dr. Wayne R. Danter, Critical Outcome Technologies Inc, London, ON. CONTACT INFORMATION Alison Silva President and CEO asilva@criticaloutcome.com PRODUCT PIPELINE • COTI is advancing a robust pipeline of compounds (Figure 3) that were identified and optimized using CHEMSAS. • This pipeline consists of targeted therapeutics focusing on innovative cancer treatments as well as drug candidates for the treatment of serious diseases where current therapies are lacking or ineffective. Figure 3. COTI’s pipeline and stage of development. CriticalOutcome.com UNITED STATES 127 Main Street Boston, MA 02129 CANADA 213-700 Collip Circle London, ON N6G 4X8 INCREASING THE ODDS OF SUCCESS STAGE OF DEVELOPMENT Library/ Compound Target Selection CHEMSAS Lead Selection Synthesis Preclinical Phase I COTI-2 COTI-219 AML Library COTI-4 COTI-58 Colon Library Other Programs* *MRSA, Multiple Sclerosis, Alzheimer’s, HIV This document may contain “forward-looking information” within the meaning of applicable securities laws. Forward-looking statements are not guarantees and are based upon current expectations, estimates, projections and assumptions. COTI operates in an environment that involves significant risks. Actual results may differ materially from these forward-looking statements. Information in this document may be superseded by more current information. Except as required by law, we do not undertake any obligation to update the information in this document.

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