Respiratory Telemetry in Large Species

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Respiratory Telemetry in Large Species

  1. 1. Respiratory Telemetry inLarge SpeciesRecording Respiratory Data, BP and ECG Rat Dual Pressure Telemetry 1
  2. 2. CorDynamics introduces telemetry that records respiratoryparameters along with blood pressure and ECG in large animals Multiple options 1) blood pressure, ECG, and respiratory parameters - simultaneous and continuous recording - combines two ICH S7 assessments in one study 2) can be used in multiple species - rabbit, dog, pig, NHP Pharmacological validation - bethanechol (cholinergic agonist)
  3. 3. Effects of bethanechol on heart rate Effect of Bethanechol (subcutaneous) on Heart Rate in the Conscious, Telemetrized Rabbit 350 300 250 200 HR (bpm) 150 100 Vehicle (n=4) 50 10 mg/kg (n=4) 0 -70 -30 10 50 90 130 170 210 250 290 330 370 410 450 490 Time (minutes)
  4. 4. Effects of bethanechol on tidal volume Effect of Bethanechol (subcutaneous) on Tidal Volume in the Conscious, Telemetrized Rabbit 30 25 20 TV (ml) 15 10 5 Vehicle (n=4) 10 mg/kg (n=4) 0 -70 -30 10 50 90 130 170 210 250 290 330 370 410 450 490 Time (minutes)
  5. 5. Effects of bethanechol on minute volume Effect of Bethanechol (subcutaneous) on Minute Volume in the Conscious, Telemetrized Rabbit 3500 Vehicle (n=4) 3000 10 mg/kg (n=4) 2500 MV (ml) 2000 1500 1000 500 0 -70 -30 10 50 90 130 170 210 250 290 330 370 410 450 490 Time (minutes)
  6. 6. Effects of bethanechol on respiratory rate Effect of Bethanechol (subcutaneous) on Respiratory Rate in the Conscious, Telemetrized Rabbit 300 Vehicle (n=4) 250 10 mg/kg (n=4) 200 Rf (breaths/min) 150 100 50 0 -70 -30 10 50 90 130 170 210 250 290 330 370 410 450 490 Time (minutes)

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