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This customized assessment leverages physiologically relevant paradigms with expert design and follow through to enable key lead optimization in drug discovery.
Subjects are dosed with either vehicle or active test article prior to administration of FeCl3 to the external surface of the carotid artery. Following this exposure to FeCl3, 3 thrombotic occlusion of the carotid artery occurs in a matter of minutes in the untreated animal. Test article efficacy can be quantitated as alterations in coronary artery blood flow along with time to occlusion.