xPatterns is a big data analytics platform as a service that enables a rapid development of enterprise-grade analytical applications. It provides tools, api sets and a management console for building an ELT pipeline with data monitoring and quality gates, a data warehouse for ad-hoc and scheduled querying, analysis, model building and experimentation, tools for exporting data to NoSql and solrCloud cluster for real-time access through low-latency/high-throughput apis as well as dashboard and visualization api/tools leveraging the available data and models. In this presentation we will showcase one of the analytical applications build on top of xPatterns for our largest customer for that runs xPatterns in production on top a data warehouse consisting of several hundreds TB of medical, pharmacy and lab data records consisting of tens of billions of records. We will showcase the xPatterns components in the form of APIs and tools employed throughout the entire lifecycle of this application. The core of the presentation is the evolution of the infrastructure from the Hadoop/Hive stack to the new BDAS Spark, Shark, Mesos and Tachyon, with lessons learned and demos.