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Systematic reviews planning the literature search 3 2017

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This workshop will provide an overview of the systematic review process with detailed information on planning the search strategy. Documentation of the search methodology and tools for managing references will also be covered.

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Systematic reviews planning the literature search 3 2017

  1. 1. Clara Fowler Research Services & Assessment Manger Research Medical Library Systematic Reviews: Planning the Literature Search
  2. 2. 1) Create a Searchable Question 2) Scoping Search 3) Searching Databases 4) Grey Literature 5) Organize & Report Results AGENDA
  3. 3. Systematic Reviews High-quality systematic reviews seek to:  Identify all relevant published evidence through systematic searching of multiple literature databases http://www.medicine.ox.ac.uk/bandolier/painres/download/whatis/syst-review.pdf
  4. 4. Create a Searchable Question Use PICO format. Create list of KEY CONCEPTS. Identify SYNONYMS & ACRONYMS.
  5. 5. Approximately 5%-30% of the population age 50 and older suffers from dry eye disease impacting visual acuity, social and physical functioning, and workplace productivity. Patients incur medical costs through frequent visits to health care professionals, as well as from prescription and over-the- counter therapies. The first line of treatment includes artificial tears and environmental coping strategies (frequent blinking and using humidifiers). There are multiple secondary treatments including topical glucocorticoids, omega-3 fatty acids, acupuncture, and surgery. A new drug, Xiidra, was approved by the FDA in 2016 to treat dry eye disease. Clinical Scenario
  6. 6. In patients with dry eye disease, does Xiidra improve patient- relevant outcomes over nonprescription artificial tears? P (Patient): Dry Eye Disease I (Intervention): Xiidra C (Comparison): artificial tears O (Outcome(s)): improvement in ocular discomfort, eye dryness, and visual impairment Create the PICO question
  7. 7. Scoping Search Is this a new question? Is there enough data available to complete a systematic review? How much time will it take to complete? 1. Search PubMed Clinical Queries & Cochrane Library to see if there are exisiting systematic reviews 2. Search PROSPERO for registered systematic reviews
  8. 8. SCOPING Search Results Conducted in the last 5 years Not in the last 5 years Done well. Change your question. Not done well. Conduct better review. Update review. Reviews exactly the same Scoping search results are going to be useful for the Introduction Section as well as important for checking their reference lists.
  9. 9. P (Patient): Dry Eye Diseases Include conditions that would create dry eye disease as well as synonyms for dry eye Dry eye disease: dry eye syndrome, dysfunctional tear syndrome, keratoconjunctivitis sicca, Sjögren's syndrome, aqueous tear-deficient dry eye, lacrimal dysfunction, lacrimal ductal obstruction, reduced reflex sensory tear secretion, decreased tear production, tear film evaporation, ocular surface irritation, chronic eye irritation, excessive tearing, blepharitis, blink rate Identify SYNONYMS
  10. 10. Artificial tears How many synonyms can you think of to use for this concept? Search Experience
  11. 11. C (Comparison): artificial tears Lubricant eye drops, artificial tear drops, lubricating eye-drops, Nonprescription drugs, non-prescription, over the counter, OTC, over-the-counter Identify SYNONYMS
  12. 12. I (Intervention): Xiidra Create a search for the drug using all name variants Brand: Xiidra Scientific: Lifitegrast Experimental: SAR 1118, SAR1118, SAR-1118 Class: lymphocyte function-associated antigen 1 (LFA-1) antagonist Identify SYNONYMS
  13. 13. What are the most important elements of this search? How can you make sure that your search is comprehensive? .
  14. 14. Select Databases To Search Cochrane Library Campbell Library MEDLINE EMBASE Web of Science CINAHL PsycINFO CENTRAL Others?
  15. 15. Publication Types JOURNAL ARTICLES MEETING ABSTRACTS CLINICAL TRIALS WEBSITES
  16. 16. Create a comprehensive list of keywords with alternate spellings Use truncation decreas* tear* irritat* Use adjacency lacrimal adj3 (dysfunction* OR obstruct*) Keywords
  17. 17. Most databases have a thesaurus or list of subject headings MeSH – MEDLINE EMTREE – EMBASE CINAHL Headlines Look up all the relevant subject headings for each concept in your search Selectively explode terms Subject Headings
  18. 18. Draft Strategy Create MEDLINE Search and review the first 50 results. Goal: Find 2-3 articles in that set that meet your inclusion criteria
  19. 19. Schedule a meeting with co-authors and review MEDLINE strategy line- by-line Use PRESS checklist to review all key search methods Revise strategy until all authors sign off. PRESS Checklist
  20. 20. PRESS CHECKLIST REVIEW SEARCH STRATEGIESSearch Experience
  21. 21. Translate Search Strategy into Other Databases Cochrane Library MEDLINE EMBASE Web of Science CINAHL PsycINFO PubMed Others?
  22. 22. EMBASE Try translating the MEDLINE strategy into the EMBASE database Search Experience
  23. 23. MEDLINE Strategy (abbreviated) 1 exp Dry Eye Syndromes/ 2 Keratoconjunctivitis Sicca/ 3 ((dry or irritat*) adj5 eye*).mp. 4 ((dysfunction* or deficien* or decreas* or evaporat* or excessive) adj5 tear*).mp. 5 1 or 2 or 3 or 4
  24. 24. IDENTIFICATION  Records identified through database searching PRISMA
  25. 25. 1. Hand Searching 2. Grey Literature 3. Contacting Experts 4. Proceedings 5. Clinicaltrials.gov 6. Cited Reference Searching 7. pubstatusaheadofprint Unpublished Literature
  26. 26. IDENTIFICATION Records identified through database searching  Additional records identified through other sources PRISMA
  27. 27. Tips Run the final searches within 24 hours Save search strategy in database as well as in a .txt file Last update search should be done within 6-months of submission for publication
  28. 28. 1. Exporting to EndNote 2. Organizing Search Results 3. De-duplication with EndNote Citation Management
  29. 29. Search Tracking Spreadsheet PRISMA Flow Diagram Documentation
  30. 30. IDENTIFICATION Records identified through database searching Additional records identified through other sources SCREENING  Records after duplicates removed PRISMA
  31. 31. Writing the SearchMethodology  List databases and other resources searched and include date search ended  Describe search strategies and filters and number of results  Include other searching methods – hand searching, reference searching, requesting data and articles  Provide a copy of the MEDLINE search for the appendix  Discussion Section: Include level of confidence that all available studies were located. Address whether search limits may have blocked retrieval of results or if other sources could have been searched. http://eahil.eu/wp-content/uploads/2015/09/3-7-Foster.pdf
  32. 32. QUESTIONS?
  33. 33. Iconsfrom TheNounProject Created by Gregory Sujkowski Created by Mickey Godfrey Created by Eric Bird Created by Olivier Guillard Created by iconsmind.com Created by Callum Taylor Created by Creative Stall

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