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Cannabinoid Synergy With Hyperbaric Oxygen - Dr. Christian Bogner

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The literature supports various pathophysiologies in individuals affected with autism spectrum disorder (ASD), including cerebral hypoperfusion, inflammation, mitochondrial dysfunction and
oxidative stress. It has been hypothesized that children affected with ASD might benefit from Hyperbaric oxygen treatment (HBOT) owing to the increase in cerebral perfusion occurring during treatment. Various hyperbaric centers have utilized HBOT to treat individuals with autism spectrum disorders (ASD). The cell-danger response and endocannabinoid signaling pathways have been described as possible key elements in the pathophysiology of microglia driven neuroinflammation, with resulting behavioral problems associated with ASD. With the growing body of evidence in the literature that describes beneficial phytocannabinoid effects in patients affected with ASD, we highlight the principle mechanisms of a novel concept, e.g. phytocannabinoid-hyperbaric-oxygen synergy and its role in paving the way for faster and lasting clinical benefits.

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Cannabinoid Synergy With Hyperbaric Oxygen - Dr. Christian Bogner

  1. 1. Hyperbaric Oxygen Cannabis Synergy Christian Bogner, MD / newsletter, presentation emailed. No notes needed.Medical Director
  2. 2. Disclosure • Oxford Recovery Center • Pharma / cannabis contributions = $0
  3. 3. Disclaimer You are encouraged to confirm any information obtained from or through this presentation with other sources, and review all information regarding any medical condition or treatment with your physician.
  4. 4. Your Path
  5. 5. The Gutters
  6. 6. Small intestine 10-17ft Large intestine ~5ft Stomach Streptococci, Lactobacilli (early) Enterococcus, Bacteroides, Clostridium, Bifidobacterium (end) 80% Bacteroides and Clostridium 90% of all intestinal bacteria Helicobacter, Streptococcus, Prevotella
  7. 7. Bifidiumbacteria Lactobacillus Clostridium
  8. 8. Clostridium
  9. 9. Clostridium
  10. 10. GLYPHOSATE
  11. 11. ‘bacteria poop’
  12. 12. β 2 toxin 4-p-cresol 5-HPHPA 4-HPA Yeast overgrowth
  13. 13. β 2 - toxin 4-p-cresol 5-HPHPA 4-HPA DOPAMINE Norepinephrine
  14. 14. DOPAMINE
  15. 15. apple slices carrot sticks sandwiches hummus water candy potato chips drank soda
  16. 16. Abilify Risperdal
  17. 17. Liver
  18. 18. Energy Immunity Recycling
  19. 19. Bacterial endotoxins Glyphosate Food protein Other toxins Leaky gut
  20. 20. MTHFR
  21. 21. MTHFR Coenzyme Q10 Creatine Melatonin Phosphatidylcholine Carnitine Glutathione Dopamine metabolism Brain derived neurotrophic factor production Homocysteine metabolism Hormones Sulfur metabolism Neurotransmitters Numerous immune components Energy Detoxification
  22. 22. MTHFR Blood clots Breast cancer Schizophrenia Alzheimer’s Disease Cleft lip/palate Anxiety Bipolar disorder Spina Bifida Autism “Present meta-analysis strongly suggested a significant association of the MTHFR C677T polymorphism with autism” Rai et al, 2016
  23. 23. MTHFR
  24. 24. Energy Immunity Recycling MTHFR MTHFR MTHFR
  25. 25. GLYPHOSATE
  26. 26. GcMAF Macrophage GLYPHOSATEx x
  27. 27. Estrogen Testosterone Aromatase GLYPHOSATE
  28. 28. Brain
  29. 29. Toxins Protein Toxins MTHFR
  30. 30. Bacterial endotoxins Aluminium Glyphosate Monosodium glutamateMercury Fluoride Insecticides Excess Dopamine
  31. 31. Microglia Neuron
  32. 32. Inflammation
  33. 33. Autism Encephalitis
  34. 34. Inflammation reduction
  35. 35. Cannabinoids ?
  36. 36. 0
  37. 37. Since 2013…
  38. 38. “Cannabinoids potentiate the production of anti-inflammatory cytokine IL-6.” Madrid, Spain, 1998 “Endo- and phytocannabinoids activate CB2 to induce cell migration.” Medical College of Wisconsin, 2004 “Cannabinoids are antioxidants and neuroprotectants." Department of Health and Human Services, US patent 6630507
  39. 39. “Cannabinoids prevents pro-inflammatory cytokine production which was induced by LPS.” -National Institute of Health, Maryland, 2003 University of Washington, 2003 “Cannabinoids activate CB2 on microglia to increase beneficiary M2 state proliferation.” -University of Washington, 2003 “THC-mediated CB2 activation resulting in fewer number of microglial cells and fewer number of degenerating neurons.” -Johann Wolfgang Goethe-Universität Frankfurt, Germany
  40. 40. Ok, now what ?
  41. 41. ‘Start low. Go slow.’ -Ethan Russo, MD
  42. 42. Safety First
  43. 43. Raw Cannabis Granny Smith apple Dandelions Carrots Celery Turmeric Ginger Chlorella Silica Stevia fruit drops Ice cold water … Maltodextrin Acesulfame potassium (SweetOne) Red 40 Blue 1 Aspartame Citric Acid Artificial flavors No ice cubes :(
  44. 44. Hyperbaric Oxygen Therapy
  45. 45. Ambient air 20.9% oxygen 1 atmosphere
  46. 46. Ambient air 100% oxygen 1 atmosphere
  47. 47. HBOT 100% Oxygen 2-3 atmospheres
  48. 48. ENERGY
  49. 49. MTHFR
  50. 50. MTHFR
  51. 51. MTHFR
  52. 52. Glucose
  53. 53. Glucose MTHFR
  54. 54. Glucose MTHFR Energy
  55. 55. Glucose MTHFR Energy
  56. 56. Intestinal Cells
  57. 57. Re-Create yourself.
  58. 58. Casey Disken Director of Applied Behavior Analysis
  59. 59. OxfordKidsFoundation.com
  60. 60. drbogner.com OxfordRecoveryCenter.com (248)486-3636 facebook.com/drbogner/ christian@oxfordrecoverycenter.com facebook.com/OxfordRecoveryCenter/

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