小榭樹( Chaparral )
• 有肝毒性
• 和 statin 併用會增加對肝臟的不好影響
Jim LK, Gee JP. Adverse effects of drugs on the liver.
In: Young LY, Koda-Kimble MA, eds. Applied
Therapeutics: The Clinical Use of Drugs. Vancouver,
WA: Applied Therapeutics, Inc; 1995:26:1-26.
聖約翰草( St John's wort )
• 降低 statin 的血中濃度 ( 但 Mevalotin 除
外 )
Sugimoto Ki K, Ohmori M, Tsuruoka S, et al. Different
effects of St John's Wort on the pharmacokinetics of
simvastatin and pravastatin. Clin Pharmacol
Ther. 2001;70:518-524.