Chemical Risk Assessment - APEG

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Chemical risk assessment presentation given at the APEG conference 2010, held by Cefas

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Chemical Risk Assessment - APEG

  1. 1. Chemical Risk Assessment Brett Lyons Environment and Animal Health Group
  2. 2. Environmental Risk Assessment • Multi-disciplinary approach to the risk assessment of organic and inorganic chemicals in aquatic ecosystems. • Fate and effects of natural and synthetic chemicals in both fresh water and marine systems (including food chain assessments). • Scientists actively involved in OECD and other international test guideline developments. – Chair UK NC3Rs (Replacement, Refinement and Reduction) Regulatory Toxicology Committee (Ecotoxicology Working Group). – OECD Endocrine Disrupters Testing & Assessment Working Group (Ecotoxicology Validation Management Group). – OECD Validation Management Group in Ecotoxicology for test guideline development (Fish Experts Group).
  3. 3. Environmental Chemistry and Fate • Extensive analytical chemistry capabilities for metals, nutrients, organic chemicals and radionuclides, including trace level environmental analyses. • Wide range of in-house specialist facilities including GC-MS, GC-MS/MS, GC-ECD, HPLC, ICP-MS and LC-MS/MS. • The high quality of Cefas science is reflected through accreditation (including GLP, ISO, MCERTS and UKAS).
  4. 4. Ecotoxicology and effects assessment • In depth skills in hazard assessment of chemicals using a suite of freshwater and marine ecotoxcity tests . • Tests include: – In vitro assays (e.g. YAS, YES, CALUX) – Acute invertebrate testing (e.g. Daphnia magna OECD 202 and 211). – Chronic partial and full life cycle invertebrate assays (shrimps, copepods, oysters, and sediment dwelling organisms) – Acute fish studies (e.g. OCED 203) – Chronic and partial life cycle fish studies including zebrafish, rainbow trout and sticklebacks (e.g. OECD 210, 212, 215) – Amphibian metamorphosis assay (OECD 231).
  5. 5. Environmental effects monitoring • Environmental monitoring is a valuable tool for environmental risk assessment (ERA) and environmental impact assessment (EIA). – Field collection environmental samples (from point source to ocean). – Biological effects testing . – Quality assured chemical analysis. – Effluent characterisation (Integrated chemical fractionation and biological effects screening). – Validation of fate effects modelling data.
  6. 6. TIE (Toxicity Identification Evaluation): identifying causes of toxicity in complex samples Complex mixture Biological analysis Chemical analysis Biological Fractionation analysis Responsible toxicant
  7. 7. Bespoke testing systems
  8. 8. The stickleback as a sentinel and model species • Small teleost (easy to keep in the lab). • Present all around the North Hemisphere. • One of three species truly endemic to the British Isles. • Fresh, estuarine, and marine waters • Well-documented biology. • Complete genome sequence (US), bridge the gap between model and sentinel species. • Unique traits/tools for endocrine disruption research and OECD type testing (early life stage, juvenile growth etc)
  9. 9. Linking biomarkers Spiggin assay to behaviour (androgens) Toxico-genomic platforms Testicular pathology: Intersex (ovotestis) Field monitoring
  10. 10. Chemical risk and population relevant endpoints Sebire et al., (2008). The model anti-androgen flutamide suppresses the expression of typical male stickleback reproductive behaviour. Aquatic Toxicology 90 (1), pp. 37-47.
  11. 11. For further information please contact: brett.lyons@cefas.co.uk jason.weeks@cefas.co.uk tom.hutchinson@cefas.co.uk

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