Case Reports, Infectious Diseases and the Developing World - Geoffrey Pasvol


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Case Reports, Infectious Diseases and the Developing World - Geoffrey Pasvol

  1. 1. Case Reports, Infectious Diseases and the Developing World Geoffrey Pasvol Professor of Infection & Tropical Medicine Consultant in Infection & Tropical Medicine Associate Editor, Transactions of the Royal Society of Tropical Medicine & Hygiene Director, Imperial Wellcome Centre for Clinical Tropical Medicine Imperial College London Celebrating Case Reports, Friday May 15, 2009
  2. 2. Out of the Tropics/Developing World ………… <ul><li>‘ ex Africa semper aliquid novi’ </li></ul><ul><li>Pliny the Elder </li></ul><ul><li>Infectious Diseases, Tropical Medicine a truly fertile ground- rich in variety, complexity and intrigue </li></ul>
  3. 3. The Triad in Case Reports <ul><li>The Reader </li></ul><ul><li>The Author </li></ul><ul><li>The Editor </li></ul>
  4. 4. So why NOT Case Reports? <ul><li>The Reader </li></ul><ul><ul><ul><li>Anecdotal </li></ul></ul></ul><ul><ul><ul><li>Unsubstantiated </li></ul></ul></ul><ul><ul><ul><li>Unedifying </li></ul></ul></ul><ul><ul><ul><li>Unscientific </li></ul></ul></ul><ul><li>The Author </li></ul><ul><ul><ul><li>Lengthy review process </li></ul></ul></ul><ul><ul><ul><li>Pot luck! </li></ul></ul></ul><ul><li>The Editor </li></ul><ul><ul><ul><li>Impact factor </li></ul></ul></ul><ul><ul><ul><li>Who will review </li></ul></ul></ul><ul><ul><ul><li>Titles/keywords to confuse or reveal? </li></ul></ul></ul><ul><li>“ CR remain CR” </li></ul>
  5. 5. So why Case Reports? <ul><li>The Reader </li></ul><ul><ul><ul><li>Aids clinical practice </li></ul></ul></ul><ul><ul><ul><li>Stimulating </li></ul></ul></ul><ul><ul><ul><li>Interesting </li></ul></ul></ul><ul><ul><ul><li>Challenging </li></ul></ul></ul><ul><li>The Author </li></ul><ul><ul><ul><li>A step on the publication ladder </li></ul></ul></ul><ul><ul><ul><li>Source of research ideas </li></ul></ul></ul><ul><ul><ul><li>Important eg ADR </li></ul></ul></ul><ul><li>The Editor </li></ul><ul><ul><ul><li>Readable </li></ul></ul></ul><ul><ul><ul><li>Space-filler </li></ul></ul></ul>
  6. 6. Transactions of the Royal Society of Tropical Medicine & Hygiene <ul><li>One of the top ranked Journals in Tropical Medicine </li></ul><ul><li>Impact Factor 2-3 </li></ul><ul><li>Published since 1907 </li></ul><ul><li>Online submission free of page charges </li></ul><ul><li>Manuscripts - peer-reviewed online </li></ul><ul><li>Accepted papers - published electronically on ScienceDirect ® and immediately indexed by PubMed </li></ul><ul><li>8 Case reports Jan 2008- May 2009 </li></ul>
  7. 7. From Bhubaneswar, India <ul><li>A successful outcome of gross haematuria (due to lymphatic filariasis) treated with diethylcarbamazine and ivermectin. </li></ul><ul><li>Kerketta et al, 2008 </li></ul>
  8. 8. From New Delhi, India <ul><li>Cutaneous leishmaniasis in Nepal: </li></ul><ul><li>Leishmania major as a cause. </li></ul><ul><li>Kumar et al, 2008 </li></ul>
  9. 9. From New Delhi, India <ul><li>Immune response following miltefosine therapy in a patient with post-kala-azar dermal leishmaniasis. </li></ul><ul><li>Ansari et al, 2008 </li></ul>
  10. 10. From Alexandroupolis, Greece <ul><li>Maggot infestation (myiasis) of external fixation pin sites in diabetic patients. </li></ul><ul><li>Verettasa et al, 2008 </li></ul>
  11. 11. From Piaui, Brazil <ul><li>Myiasis in the uterine cavity of an elderly woman with a complete uterine prolapse. </li></ul><ul><li>Lopes-Costa et al, 2008 </li></ul>
  12. 12. From Lima, Peru <ul><li>Cervical tumor caused by the sexually mature stage of Fasciola hepatica. </li></ul><ul><li>Luis et al, 2009 </li></ul>
  13. 13. From Cape Town, South Africa <ul><li>First case report of pharyngeal cysticercosis. </li></ul><ul><li>Sobnach et al, 2009 </li></ul>
  14. 14. From Khon Kaen, Thailand <ul><li>Sequential imaging studies of cerebral gnathostomiasis with subdural hemorrhage as its complication. </li></ul><ul><li>Sawanyawisutha et al, 2009 </li></ul><ul><li>Gnathostoma spinigerum </li></ul>
  15. 15. Case Reports and the Developing World <ul><li>The Reader </li></ul><ul><ul><ul><li>Access: Internet, CD, DVD, paper, laminated cards </li></ul></ul></ul><ul><ul><ul><li>A repository of knowledge </li></ul></ul></ul><ul><ul><ul><li>‘ Small Is Beautiful’ </li></ul></ul></ul><ul><li>The Author </li></ul><ul><ul><ul><li>Disadvantaged: Lacks diagnostic tools (esp dev countries) </li></ul></ul></ul><ul><ul><ul><li>Language </li></ul></ul></ul><ul><ul><ul><li>Open access? </li></ul></ul></ul><ul><ul><ul><li>Encouraging </li></ul></ul></ul><ul><ul><ul><li>Inclusive </li></ul></ul></ul><ul><li>The Editor </li></ul><ul><ul><ul><li>Colour; powerful image </li></ul></ul></ul><ul><ul><ul><li>Reviewing- what allowances </li></ul></ul></ul><ul><ul><ul><li>Copyediting </li></ul></ul></ul>
  16. 16. Confessions………… <ul><li>1984 Pneumonia due to Legionella bozemanii first report of a case in Europe. Journal of Infection 8: 251-255. </li></ul><ul><li>1996 Leptospirosis in pregnancy: an unusual and relatively unrecognised cause of death in man. Journal of Obstetrics and Gynaecology 16: 163-165 </li></ul><ul><li>*1996 Fatal quinine cardiotoxicity in the treatment of falciparum malaria. Transactions Royal Society of Tropical Medicine 90: 305-307. </li></ul><ul><li>2000 Acute adrenal insufficiency precipitated by isolated involvement of the adrenal gland by tuberculosis. Journal of Infection. 39: 244-245. </li></ul><ul><li>*2002 Malarone ® treatment failure and in vitro confirmation of resistance of P falciparum isolate from Lagos, Nigeria. Malaria Journal 1(1) 1-4 </li></ul><ul><li>2002 Severe acute symptomatic hyponatraemia in falciparum malaria. Transactions of the Royal Society of Tropical Medicine 96: 647-648 </li></ul><ul><li>2003 Amoebic abscess in the left lobe of the liver masquerading as pyelonephritis. Journal of Infection 46: 249-250 </li></ul><ul><li>*2005 Kikuchi's disease: a rare cause of meningitis? Clinical Infectious Diseases. 41:e80-2. </li></ul><ul><li>*2005 Pneumococcal meningitis and etanercept--chance or association? Journal of Infection. 51:E49-51 . </li></ul><ul><li>(2005) Images in clinical medicine Chromoblastomycosis. New England Journal of Medicine. 352 : e19. </li></ul><ul><li>(2005) Successful treatment of severe Kikuchi’s disease with intravenous immunoglobulin. Rheumatology. 235-236 </li></ul>
  17. 17. “From Case Report to Clinic……”
  18. 18. “From Case Report to Clinic……”
  19. 19. “From Case Report to Clinic……”
  20. 20. So for all………. <ul><li>Raises questions </li></ul><ul><li>Ambivalence </li></ul><ul><li>The best- the worst </li></ul><ul><li>Just because they are fun, harmless but possess potential </li></ul><ul><li>Teach, research and practice </li></ul><ul><li>So why not celebrate? </li></ul>
  21. 21. Lest anyone doubt …………………. <ul><li>‘ I come to celebrate case reports, not to bury them !’ </li></ul><ul><li>Plenty the Wiser </li></ul>
  22. 22. Acknowledgements <ul><li>Bo Drasar (Editor) and The Transactions of the Royal Society of Tropical Medicine and Hygiene </li></ul><ul><li> </li></ul><ul><li>Healthcare Information for all by 2015 </li></ul><ul><li>www. hifa2015 .org </li></ul><ul><li>The Organisers </li></ul>