Personal Data Tracking and the Digital Transformation of Healthcare

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12.12.05
Invited Talk
University of Illinois Silicon Valley Round Table
Title:Personal Data Tracking and the Digital Transformation of Healthcare
Palo Alto, CA

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Personal Data Tracking and the Digital Transformation of Healthcare

  1. 1. “Personal Data Tracking and the Digital Transformation of Healthcare” Invited Talk University of Illinois Silicon Valley Round Table Palo Alto, CA December 5, 2012 Dr. Larry SmarrDirector, California Institute for Telecommunications and Information Technology Harry E. Gruber Professor, Dept. of Computer Science and Engineering 1 Jacobs School of Engineering, UCSD
  2. 2. Calit2 Has Been Had a Vision of “the Digital Transformation of Health” for a Decade www.bodymedia.com• Next Step—Putting You On-Line! – Wireless Internet Transmission – Key Metabolic and Physical Variables – Model -- Dozens of Processors and 60 Sensors / Actuators Inside of our Cars• Post-Genomic Individualized Medicine – Combine – Genetic Code – Body Data Flow – Use Powerful AI Data Mining Techniques The Content of This Slide from 2001 Larry Smarr Calit2 Talk on Digitally Enabled Genomic Medicine
  3. 3. The Calit2 Vision of Digitally Enabled Genomic Medicine is an Emerging Reality 3 July/August 2011 February 2012
  4. 4. I Arrived in La Jolla in 2000of My Body andin the Midwest By Measuring the State After 20 Years “Tuning” It Using Nutrition and Exercise, Ithe Obesity Trend and Decided to Move Against Became Healthier Age Age Age 41 51 61 1999 2010 2000 1999 1989 I Reversed My Body’s Decline By Altering Nutrition and Exercise
  5. 5. Is Government and Medical Advice Driving the Obesity Epidemic? The Low-Carb Alternative Avoid High Glycemic Carbs Which Spike Your Glucose-Insulin Cycle
  6. 6. Wireless MonitoringHelps Drive Exercise Goals
  7. 7. Quantifying My Sleep Pattern Using a Zeo - Increased My Average to 8 Hours/Night Stroke risk increased by sleeping less than six hours a night -M. Ruiter, Sleep 2012 REM is Normally 20% of Sleep An Infant Typically Mine is Between 45-65% of Sleep Has 50% REM
  8. 8. Challenge-Coupling Personal Sensor Data With Social Networks Across Private Clouds Withing/iPhone- Blood Pressure Body Media- Calories Burned Lose It-Calories Ingested EM Wave PC- Stress Azumio-Heart Rate Zeo-Sleep
  9. 9. From One to a Billion Data Points Defining Me:The Exponential Rise in Body Data in Just One Decade! Billion:Microbial Genome My Full DNA, MRI/CT Images Improving Body SNPs Million: My DNA SNPs, Zeo, FitBit Discovering Disease Blood Variables One: Hundred: My Blood Variables Weight Weight My
  10. 10. From Measuring Macro-Variablesto Measuring Your Internal Variables www.technologyreview.com/biomedicine/39636
  11. 11. I Track 100 Variables in Blood Tests Done Quarterly to Annually• Electrolytes • Liver – Sodium, Potassium, Calcium, – GGTP, SGOT, SGPT, LDH, Total Magnesium, Phosphorus, Boron, Direct Bilirubin, Chlorine, CO2 Alkaline Phosphatase• Micronutrients • Thyroid – Arsenic, Chromium, Cobalt, – T3 Uptake, T4, Free Thyroxine Copper, Iron, Manganese, Index, FT4, 2nd Gen TSH Molybdenum, Selenium, Zinc • Blood Cells• Blood Sugar Cycle – Complete Blood Cell Count – Glucose, Insulin, A1C Hemoglobin – Red Blood Cell Subtypes• Cardio Risk – White Blood Cell Subtypes – Complex Reactive Protein • Cancer Screen – Homocysteine – CEA, Total PSA, % Free PSA• Kidneys – CA-19-9 – Bun, Creatinine, Uric Acid • Vitamins & Antioxidant Screen• Protein – Vit D, E; Selenium, ALA, coQ10, – Total Protein, Albumin, Globulin Glutathione, Total Antioxidant Fn. Only One of These Was Far Out of Normal Range
  12. 12. My Blood Measurements Revealed Chronic Inflammation Episodic Peaks in Inflammation 27x Followed by Spontaneous Drop 15x Antibiotics5x Antibiotics Normal Range CRP < 1 Complex Reactive Protein (CRP) is a Blood Biomarker for Detecting Presence of Inflammation
  13. 13. Startup WellnessFX Enables You to Track Your Own Blood Variables LS Values from WellnessFX.com
  14. 14. By Quantifying Stool Measurements Over TimeI Discovered Source of Inflammation Was Likely in Colon 124x Upper Limit Typical Lactoferrin Value for Stool Samples Analyzed Active by www.yourfuturehealth.com IBD Normal Range <7.3 µg/mL Lactoferrin is a Sensitive and Specific Biomarker for Detecting Presence of Inflammatory Bowel Disease (IBD)
  15. 15. Confirming the IBD (Crohn’s) Hypothesis: Finding the “Smoking Gun” with MRI Imaging Liver I Obtained the MRI Slices Transverse Colon From UCSD Medical Services and Converted to Interactive 3D Working With Small Intestine Calit2 Staff & DeskVOX Software Descending Colon MRI Jan 2012Cross Section Diseased Sigmoid Colon Major Kink Sigmoid Colon Threading Iliac Arteries
  16. 16. Interactive Visualization and 3D Hard Copy from LS MRI Data Research: Calit2 FutureHealth Team
  17. 17. Why Did I Have an Autoimmune Disease like IBD? Despite decades of research, the etiology of Crohns disease remains unknown. Its pathogenesis may involve a complex interplay between host genetics, immune dysfunction, and microbial or environmental factors. --The Role of Microbes in Crohns Disease So I Set Out to Quantify All Three! Paul B. Eckburg & David A. Relman Clin Infect Dis. 44:256-262 (2007) 
  18. 18. I Wondered if Crohn’s is an Autoimmune Disease, Did I Have a Personal Genomic Polymorphism? From www.23andme.com Polymorphism in Interleukin-23 Receptor Gene — 80% Higher Risk ATG16L1 of Pro-inflammatory Immune Response IRGM NOD2 SNPs Associated with CD
  19. 19. Putting Multiple Immunological Biomarker Time Series Together, Reveals Major Immune Dysfunction Green : Inside Range Orange: 1-10x Over Red: 10-100x Over Purple: >100x Over Source: Calit2 Future Health Expedition Team
  20. 20. Determining My Gut Microbes and Their Time Variation Shipped Stool Sample December 28, 2011 I Received a Disk Drive April 3, 2012 With 35 GB FASTQ Files Weizhong Li, UCSD NGS Pipeline: 230M Reads Only 0.2% Human Required 1/2 cpu-yr Per Person Analyzed!
  21. 21. Phyla Gut Microbial Abundance: LS, Crohn’s, UC, and Healthy SubjectsLS Crohn’s Ulcerative Healthy Colitis
  22. 22. Startups Are Enabling Genomic Sequencing of Your Microbiome
  23. 23. Where I Believe We are Headed: Predictive,Personalized, Preventive, & Participatory Medicine I am Leroy Hood’s Lab Rat! www.newsweek.com/2009/06/26/a-doctor-s-vision-of-the-future-of-medicine.html

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