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DISTRIBUTION OF SYMPTOMS IN THE OVERALL
POPULATION 2014 (ERCUSYN database)
Weight gain (81%), hypertension (75%), skin alterations (72%),
myopathy (67%) and hirsutism (58%) were the most frequent symptoms.
Great % of not known info (i.e. 63% for reduced libido)
0
10
20
30
40
50
60
70
80
90
w
eightgain
hypertension
skin
alterationsm
yopathyhirsutism
m
enstrualirregularities
diabetes
m
ellitusdepression
hairloss
libido
reduction
fractures
Cushing’s syndrome has a significant
impact on health related quality of life (QoL)
• Despite long-term cure of
CS, patients experience
impaired QoL, with
physical and
psychosocial limitations,
especially in the presence
of hypopituitarism
van Aken MO et al. Quality of life in patients after long-term biochemical cure
of Cushing’s disease. J Clin Endocrinol Metab. 2005;90(6):3279-86.
Baseline 0-3 3-12 12-24 >24
Time (months)
VASEuroQoL
ERCUSYN: THE VISUAL ANALOG SCALE (VAS) OF THE EUROQoL
SLOWLY IMPROVES IN PATIENTS IN REMISSION AFTER SURGERY
Sleep Pain
Wound healing Easy bruising
* *
* **
*
*
*
SIGNIFICANT IMPROVEMENT OF THE CUSHING QoL
PHYSICAL ITEMS IN THE POSTOPERATIVE PERIOD (ERCUSYN
data)
*
0
0.5
1
1.5
2
2.5
3
3.5
4
Baseline 0-3 mo 3-12 mo 12-24 mo >24 mo
0
0.5
1
1.5
2
2.5
3
3.5
4
4.5
Baseline 0-3 mo 3-12 mo 12-24 mo >24 mo
0
0.5
1
1.5
2
2.5
3
3.5
Baseline 0-3 mo 3-12 mo 12-24 mo >24 mo
0
0.5
1
1.5
2
2.5
3
3.5
4
Baseline 0-3 mo 3-12 mo 12-24 mo >24 mo
THE CUSHING QoL PSYCHOLOGICAL ITEMS IMPROVE IN THE
POSTOPERATIVE PERIOD, BUT MEMORY DOES NOT !
(ERCUSYN data)
0
0.5
1
1.5
2
2.5
3
3.5
4
Baseline 0-3 mo 3-12 mo 12-24 mo >24 mo
0
0.5
1
1.5
2
2.5
3
3.5
4
Baseline 0-3 mo 3-12 mo 12-24 mo >24 mo
0
0.5
1
1.5
2
2.5
3
3.5
4
Baseline 0-3 mo 3-12 mo 12-24 mo >24 mo
0
1
2
3
4
Baseline 0-3 mo 3-12 mo 12-24 mo >24 mo
Irritability Physical appearance
Daily activity Memory

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Cushing's Quality of Life Webinar Missing Slides

  • 1. DISTRIBUTION OF SYMPTOMS IN THE OVERALL POPULATION 2014 (ERCUSYN database) Weight gain (81%), hypertension (75%), skin alterations (72%), myopathy (67%) and hirsutism (58%) were the most frequent symptoms. Great % of not known info (i.e. 63% for reduced libido) 0 10 20 30 40 50 60 70 80 90 w eightgain hypertension skin alterationsm yopathyhirsutism m enstrualirregularities diabetes m ellitusdepression hairloss libido reduction fractures
  • 2. Cushing’s syndrome has a significant impact on health related quality of life (QoL) • Despite long-term cure of CS, patients experience impaired QoL, with physical and psychosocial limitations, especially in the presence of hypopituitarism van Aken MO et al. Quality of life in patients after long-term biochemical cure of Cushing’s disease. J Clin Endocrinol Metab. 2005;90(6):3279-86.
  • 3. Baseline 0-3 3-12 12-24 >24 Time (months) VASEuroQoL ERCUSYN: THE VISUAL ANALOG SCALE (VAS) OF THE EUROQoL SLOWLY IMPROVES IN PATIENTS IN REMISSION AFTER SURGERY
  • 4. Sleep Pain Wound healing Easy bruising * * * ** * * * SIGNIFICANT IMPROVEMENT OF THE CUSHING QoL PHYSICAL ITEMS IN THE POSTOPERATIVE PERIOD (ERCUSYN data) * 0 0.5 1 1.5 2 2.5 3 3.5 4 Baseline 0-3 mo 3-12 mo 12-24 mo >24 mo 0 0.5 1 1.5 2 2.5 3 3.5 4 4.5 Baseline 0-3 mo 3-12 mo 12-24 mo >24 mo 0 0.5 1 1.5 2 2.5 3 3.5 Baseline 0-3 mo 3-12 mo 12-24 mo >24 mo 0 0.5 1 1.5 2 2.5 3 3.5 4 Baseline 0-3 mo 3-12 mo 12-24 mo >24 mo
  • 5. THE CUSHING QoL PSYCHOLOGICAL ITEMS IMPROVE IN THE POSTOPERATIVE PERIOD, BUT MEMORY DOES NOT ! (ERCUSYN data) 0 0.5 1 1.5 2 2.5 3 3.5 4 Baseline 0-3 mo 3-12 mo 12-24 mo >24 mo 0 0.5 1 1.5 2 2.5 3 3.5 4 Baseline 0-3 mo 3-12 mo 12-24 mo >24 mo 0 0.5 1 1.5 2 2.5 3 3.5 4 Baseline 0-3 mo 3-12 mo 12-24 mo >24 mo 0 1 2 3 4 Baseline 0-3 mo 3-12 mo 12-24 mo >24 mo Irritability Physical appearance Daily activity Memory

Editor's Notes

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