Nature has been perhaps the most important source of inspiration for design, especially for design that strives to positively influence nature and planet earth. Many different design strategies have developed over the last decades, and many designers are familiar with eco-design, Cradle to Cradle, or biomimicry, and, more recently, circular design. But what are the differences between these design strategies, and how, as a designer, do you know which one to use? By applying these strategies to one specific design problem, experts on these different strategies answer this question. The results demonstrate that each of these design strategies is different, even though they are all inspired by nature. The different approach and focus of each strategy results in a range of design solutions. For designers, the challenge lies in understanding these differences and choosing the most appropriate strategy for the design problem in question.