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www.neuroservice.com
CORPORATE
PRESENTATION
March, 2015
www.neuroservice.com
SUMMARY
OUR
SOLUTIONS
OUR
COMMITMENTS
YOUR
INTERLOCUTORS
WHO
WE ARE
OUR
TECHNIQUES
OUR FOCUS
AREAS
www.neuroservice.com
WHO WE ARE
OUR
SOLUTIONS
OUR
COMMITMENTS
YOUR
INTERLOCUTORS
WHO
WE ARE
OUR
TECHNIQUES
OUR FOCUS
AREAS
www.neuroservice.com
WHO WE ARE
Core business activity
A Contract Research Organization (CRO)
Testing the effect of ANY CO...
www.neuroservice.com
WHAT WE DO
Core business activity
IN VITRO TESTS
UNDER PHYSIOLOGICAL CONDITIONS
In rodent (or human) ...
www.neuroservice.comwww.neuroservice.com
WHAT WE DO
Electrophysiological recordings
www.neuroservice.com
WHAT WE PROPOSE FOR DRUG DISCOVERY
Your remote laboratory
Hits
Leads
Advanced
candidate
IND
LEAD
SELE...
www.neuroservice.com
WHO WE ARE
Key features
Launched in Aix-en-Provence in 2006
Portfolio of 150 studies
60 worldwide cli...
www.neuroservice.com
OUR TECHNIQUES
OUR
SOLUTIONS
OUR
COMMITMENTS
YOUR
INTERLOCUTORS
WHO
WE ARE
OUR
TECHNIQUES
OUR FOCUS
A...
www.neuroservice.comwww.neuroservice.com
OUR TECHNIQUES
Multi-Electrode Arrays (MEA) technique
www.neuroservice.comwww.neuroservice.com
OUR TECHNIQUES
Patch-Clamp technique
www.neuroservice.com
OUR TECHNIQUES: THE IDEAL COMBINATION
Patch-Clamp
Electrode
MEA Electrode
www.neuroservice.com
OUR TECHNIQUES: A COMPREHENSIVE COMBINATION
Different structures and protocols
MATERIAL STRUCTURE PRO...
www.neuroservice.com
OUR TECHNIQUES: THE IDEAL COMBINATION
In vitro evaluation of compounds under the most physiologically...
www.neuroservice.com
OUR FOCUS AREAS
OUR
SOLUTIONS
OUR
COMMITMENTS
YOUR
INTERLOCUTORS
WHO
WE ARE
OUR
TECHNIQUES
OUR FOCUS
...
www.neuroservice.com
OUR FOCUS AREA
LEAD
SELECTION &
OPTIMIZATION
MECHANISM
OF ACTION
SAFETY &
TOXICOLOGY
PROFILING
SOLUTI...
www.neuroservice.com
SOLUTIONS FOR DRUG DISCOVERY
Example with MEA technique
www.neuroservice.com
SOLUTIONS FOR DRUG DISCOVERY
Example with MEA technique
ACCURATE PHARMACOLOGY
CHOLINERGIC RECEPTOR-ME...
www.neuroservice.com
EXAMPLE WITH MEA TECHNIQUE
Tg Rodent Phenotyping
ELECTROPHYSIOLOGY IN BRAIN SLICES FROM
GENETICALLY E...
www.neuroservice.com
SOLUTIONS FOR DRUG DISCOVERY
Example with Patch-Clamp
CHOLINERGIC RECEPTOR-MEDIATED INCREASE
OF CA1 P...
www.neuroservice.com
SOLUTIONS FOR DRUG DISCOVERY
Example with Patch-Clamp
PHARMACOLOGICAL CHARACTERIZATION OF SODIUM CURR...
www.neuroservice.com
 Human tissue management
Protocol design
 Patch Clamp recording
HUMAN BRAIN SLICE RECORDINGS
A par...
www.neuroservice.com
HUMAN BRAIN SLICE RECORDINGS
STRUCTURE MATERIAL PROTOCOLS
Neurons passive membrane properties
AMPA/ka...
www.neuroservice.com
SOLUTIONS FOR SAFETY
Focus areas
CUSTOMER WORK FLOW
Advanced candidate
MECHANISM
OF ACTION
SAFETY &
T...
www.neuroservice.com
OUR SOLUTIONS
OUR
SOLUTIONS
OUR
COMMITMENTS
YOUR
INTERLOCUTORS
WHO
WE ARE
OUR
TECHNIQUES
OUR FOCUS
AR...
www.neuroservice.com
OUR SOLUTIONS
Neuroservice: your remote laboratory
Outsourced Assays R&D Customized Solutions Package...
www.neuroservice.comwww.neuroservice.com
OUTSOURCED R&D
Highly skilled scientists
Flexible Multi-Platform
FTE Contract
www.neuroservice.comwww.neuroservice.com
CUSTOMIZED SOLUTIONS
More than 150 studies already provided
Fee for Service
Contr...
www.neuroservice.com
NEUROSAFETY PACKAGE
General profiling on synaptic properties
●
At least one effect detected
!
PROPOSA...
www.neuroservice.com
PRO-CONVULSIVE PACKAGE
Prediction of convulsive properties
●
At least one effect detected
TEST 1, TES...
www.neuroservice.com
GAMMA OSCILLATIONS PACKAGE
A translational biomarker
Neuronal rhythms are
altered in schizophrenia,
e...
www.neuroservice.com
DRG SODIUM PACKAGE (PAIN)
Effects on DRG Na+ Channels
Sodium channels are involved in pain
associated...
www.neuroservice.com
OUR COMMITMENTS
OUR
SOLUTIONS
OUR
COMMITMENTS
YOUR
INTERLOCUTORS
WHO
WE ARE
OUR
TECHNIQUES
OUR FOCUS
...
www.neuroservice.com
OUR COMMITMENTS
QUALITY ROBUST AND REPRODUCIBLE DATA
SHORT TURNAROUND 100 VALIDATED SLICES OR 40 NEUR...
www.neuroservice.com
YOUR INTERLOCUTORS
OUR
SOLUTIONS
OUR
COMMITMENTS
YOUR
INTERLOCUTORS
WHO
WE ARE
OUR
TECHNIQUES
OUR FOC...
www.neuroservice.com
YOUR INTERLOCUTORS
BRUNO BUISSON, PhD
Founder
General manager &
Chief scientist
SCIENTIFIC TEAM
Based...
www.neuroservice.comYour partner for hands-on CNS electrophysiology
Domaine de St Hilaire
595, rue Pierre CS 30531
13 593 ...
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NEUROSERVICE-Corporate_2015

  1. 1. www.neuroservice.com CORPORATE PRESENTATION March, 2015
  2. 2. www.neuroservice.com SUMMARY OUR SOLUTIONS OUR COMMITMENTS YOUR INTERLOCUTORS WHO WE ARE OUR TECHNIQUES OUR FOCUS AREAS
  3. 3. www.neuroservice.com WHO WE ARE OUR SOLUTIONS OUR COMMITMENTS YOUR INTERLOCUTORS WHO WE ARE OUR TECHNIQUES OUR FOCUS AREAS
  4. 4. www.neuroservice.com WHO WE ARE Core business activity A Contract Research Organization (CRO) Testing the effect of ANY COMPOUNDS on Central Nervous System tissues
  5. 5. www.neuroservice.com WHAT WE DO Core business activity IN VITRO TESTS UNDER PHYSIOLOGICAL CONDITIONS In rodent (or human) acute brain slices In rodent spinal cord slices In rodent cultured neurons
  6. 6. www.neuroservice.comwww.neuroservice.com WHAT WE DO Electrophysiological recordings
  7. 7. www.neuroservice.com WHAT WE PROPOSE FOR DRUG DISCOVERY Your remote laboratory Hits Leads Advanced candidate IND LEAD SELECTION & OPTIMIZATION MECHANISM OF ACTION SAFETY & TOXICOLOGY PROFILING CLINICAL RESEARCH R&DPRÉ-CLINICAL DEVELOPMENT
  8. 8. www.neuroservice.com WHO WE ARE Key features Launched in Aix-en-Provence in 2006 Portfolio of 150 studies 60 worldwide clients (Pfizer, Roche, CHDI…) 35 people – 2 laboratories Capital: 520 000€ Income 2014 : 2,7 M€
  9. 9. www.neuroservice.com OUR TECHNIQUES OUR SOLUTIONS OUR COMMITMENTS YOUR INTERLOCUTORS WHO WE ARE OUR TECHNIQUES OUR FOCUS AREAS
  10. 10. www.neuroservice.comwww.neuroservice.com OUR TECHNIQUES Multi-Electrode Arrays (MEA) technique
  11. 11. www.neuroservice.comwww.neuroservice.com OUR TECHNIQUES Patch-Clamp technique
  12. 12. www.neuroservice.com OUR TECHNIQUES: THE IDEAL COMBINATION Patch-Clamp Electrode MEA Electrode
  13. 13. www.neuroservice.com OUR TECHNIQUES: A COMPREHENSIVE COMBINATION Different structures and protocols MATERIAL STRUCTURE PROTOCOL Input/Output Properties Paired-Pulse Protocol Basal Synaptic Transmission Long-Term Potentiation Long-Term Depression Short-Term Potentiation Firing Activity Dose-Response Protocol Spontaneous Postsynaptic Current Agonist Evoked Postsynaptic Current Pharmacology of Intracellular Pathways Hippocampus Cortex Cerebellum Spinal Cord with or without root Ventral Tegmental Area Striatum Substantia Nigra Locus Coeruleus Periaqueductal Gray Matter Dorsal Raphe Amygdala Thalamus Dorsal Vagal Nucleus i In vitro rodent slices
  14. 14. www.neuroservice.com OUR TECHNIQUES: THE IDEAL COMBINATION In vitro evaluation of compounds under the most physiologically relevant conditions Robust and reproducible high quality data Reducing animal and compound use Exceptional macroscopic view of neuronal networks Ability to record multiple evoked-responses in parallel within a single slice Mid-throughput production capabilities Refined investigation of compounds’ effect on single proteins/receptors Large catalog of CNS structures and neuronal cell types to address effects on specific neurons, neurotransmitter systems or receptors NEURONAL NETWORK SINGLE NEURON PATCH-CLAMPMEA (Multi-Electrode Arrays))
  15. 15. www.neuroservice.com OUR FOCUS AREAS OUR SOLUTIONS OUR COMMITMENTS YOUR INTERLOCUTORS WHO WE ARE OUR TECHNIQUES OUR FOCUS AREAS Drug Discovery Safety
  16. 16. www.neuroservice.com OUR FOCUS AREA LEAD SELECTION & OPTIMIZATION MECHANISM OF ACTION SAFETY & TOXICOLOGY PROFILING SOLUTIONS FOR CNS DRUG DISCOVERY SOLUTIONS FOR SAFETY: Testing the effect of any type of drug, molecule… on CNS and investigate its mechanism of action
  17. 17. www.neuroservice.com SOLUTIONS FOR DRUG DISCOVERY Example with MEA technique
  18. 18. www.neuroservice.com SOLUTIONS FOR DRUG DISCOVERY Example with MEA technique ACCURATE PHARMACOLOGY CHOLINERGIC RECEPTOR-MEDIATED INCREASE OF CA1 PYRAMIDAL NEURONS FIRING CARBACHOL & PIRENZEPINE M1 MUSCARINIC ACETYLCHOLINE RECEPTORS A B CPirenzepineCarbachol
  19. 19. www.neuroservice.com EXAMPLE WITH MEA TECHNIQUE Tg Rodent Phenotyping ELECTROPHYSIOLOGY IN BRAIN SLICES FROM GENETICALLY ENGINEERED MICE: Mice deficit (or gain) determination Physiological characterizations Drug evaluation in a disease model FASTER 2 weeks LESS ANIMALS REQUIRED 10 WT / 10 Tg … in comparison with behavioural tests LESS COMPOUNDS REQUIRED
  20. 20. www.neuroservice.com SOLUTIONS FOR DRUG DISCOVERY Example with Patch-Clamp CHOLINERGIC RECEPTOR-MEDIATED INCREASE OF CA1 PYRAMIDAL NEURONS FIRING CARBACHOL & PIRENZEPINE EXPERIMENT Miniature inhibitory postsynaptic currents (mIPSCs) in lamina II of adult spinal cord mice DATA mIPSC frequency, amplitude distribution and detailed analysis of the average mIPSC waveform (including amplitude, rise time, decay time) 100 pA 100 s Strychnine 1 µM Rat, p15, lamina X TTX, 0.5 µM + ORG 24598, 10 µM, 35°C dorsal ventral II III 10x
  21. 21. www.neuroservice.com SOLUTIONS FOR DRUG DISCOVERY Example with Patch-Clamp PHARMACOLOGICAL CHARACTERIZATION OF SODIUM CURRENTS IN DRG TTXs and TTXr sodium current n=6 TTXs sodium current n=6 TTXr sodium current n=3 Mice DRG (12 weeks) Rat DRG (12 weeks) Inactivation Inactivation Inactivation
  22. 22. www.neuroservice.com  Human tissue management Protocol design  Patch Clamp recording HUMAN BRAIN SLICE RECORDINGS A partnership customized to client needs EXPERT INTERFACE WITH CLIENT REMOTE LABORATORY Customer Relationship Management Quotation & Contractual Paperwork Contract and Project Management Raw data validation & Final report Clients
  23. 23. www.neuroservice.com HUMAN BRAIN SLICE RECORDINGS STRUCTURE MATERIAL PROTOCOLS Neurons passive membrane properties AMPA/kainate “minis” or evoked-currents NMDA evoked-currents GABAA “minis” or evoked-currents … Small areas of cortical brain tissue Neurosurgical resections from adult patients For purely medical reasons (informed consent given by patients) Surgery approved by independent Board of Physicians All is supervised by the Ethical Committee from the University of Freiburg (in accordance with both national and international guidelines)
  24. 24. www.neuroservice.com SOLUTIONS FOR SAFETY Focus areas CUSTOMER WORK FLOW Advanced candidate MECHANISM OF ACTION SAFETY & TOXICOLOGY PROFILING CLINICAL RESEARCH Safety Studies !
  25. 25. www.neuroservice.com OUR SOLUTIONS OUR SOLUTIONS OUR COMMITMENTS YOUR INTERLOCUTORS WHO WE ARE OUR TECHNIQUES OUR FOCUS AREAS
  26. 26. www.neuroservice.com OUR SOLUTIONS Neuroservice: your remote laboratory Outsourced Assays R&D Customized Solutions Packages DRIVE OUR RESSOURCES CUSTOMIZE OUR ASSAYS CHOOSE A READY TO USE SOLUTION Highly experienced team in neurophysiology, neuropharmacology and neurotoxicology Portfolio of 150 studies • High quality data •Short turnaround time •Mid-throughput production capabilities 4 packages:
  27. 27. www.neuroservice.comwww.neuroservice.com OUTSOURCED R&D Highly skilled scientists Flexible Multi-Platform FTE Contract
  28. 28. www.neuroservice.comwww.neuroservice.com CUSTOMIZED SOLUTIONS More than 150 studies already provided Fee for Service Contract
  29. 29. www.neuroservice.com NEUROSAFETY PACKAGE General profiling on synaptic properties ● At least one effect detected ! PROPOSAL FOR FURTHER INVESTIGATION
  30. 30. www.neuroservice.com PRO-CONVULSIVE PACKAGE Prediction of convulsive properties ● At least one effect detected TEST 1, TEST 2 or TEST 3 TEST 1 TEST 2 TEST 3 OK● ●● ! PROPOSAL FOR FURTHER INVESTIGATION
  31. 31. www.neuroservice.com GAMMA OSCILLATIONS PACKAGE A translational biomarker Neuronal rhythms are altered in schizophrenia, epilepsy, autism, ADHD, Alzheimer and Parkinson Diseases.
  32. 32. www.neuroservice.com DRG SODIUM PACKAGE (PAIN) Effects on DRG Na+ Channels Sodium channels are involved in pain associated with neuropathy, diabetes, osteoarthritis and surgery. (1 mM) (1 mM)
  33. 33. www.neuroservice.com OUR COMMITMENTS OUR SOLUTIONS OUR COMMITMENTS YOUR INTERLOCUTORS WHO WE ARE OUR TECHNIQUES OUR FOCUS AREAS
  34. 34. www.neuroservice.com OUR COMMITMENTS QUALITY ROBUST AND REPRODUCIBLE DATA SHORT TURNAROUND 100 VALIDATED SLICES OR 40 NEURONS / WEEK EXPERTISE INTERACTIVE AND EXPERT SUPPORT FLEXIBILITY STEP-BY-STEP STUDY PLANS ETHICS MINIMIZED ANIMAL USE
  35. 35. www.neuroservice.com YOUR INTERLOCUTORS OUR SOLUTIONS OUR COMMITMENTS YOUR INTERLOCUTORS WHO WE ARE OUR TECHNIQUES OUR FOCUS AREAS
  36. 36. www.neuroservice.com YOUR INTERLOCUTORS BRUNO BUISSON, PhD Founder General manager & Chief scientist SCIENTIFIC TEAM Based in JapanBased in USA TATSUO MIYAUCHI, PhD Scientific liaison JEFFREY SPROUSE, PhD Scientific liaison OLIVIER TOURY Co-Founder Deputy general manager & Chief of business development MAI SAITO Asia Business Developer LINDA HOUAICHI USA & Europe Business Developer ESTHER STEIDL, MsSc Co-founder Head of the Multi-Electrode Array laboratory BOGDAN SAVA, PhD Head of the Patch-Clamp laboratory BUSINESS TEAM
  37. 37. www.neuroservice.comYour partner for hands-on CNS electrophysiology Domaine de St Hilaire 595, rue Pierre CS 30531 13 593 Aix-en-Provence Cedex 3 FRANCE Tel : +33 (0)442 991 220 contact@neuroservice.com www.neuroservice.com

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