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RNAi and microRNA-mediated gene regulation

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An animated explanation of RNA interference (RNAi) and microRNA-mediated gene regulation.

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RNAi and microRNA-mediated gene regulation

  1. 1. GENE RNA PROTEINm sRNA RNA interference transcription translation miRNA carried by Argonaute (Ago) siRNA DNA micro-RNA small interfering RNA messenger small RNA amino acids outside (exogenous) sources RNA translational inhibition mRNA degradation RNAi not all genes make protein target binding
  2. 2. miRNA/siRNA biogenesis Dicer Microprocessor Nucleus Cytoplasm Argonaute pre-RISC (RNA-induced silencing complex) mature RISC (core) pri-miRNApre-miRNA RNA duplex exogenous dsRNA (siRNA precursors)
  3. 3. Ago effector pathway target binding perfect complementarity (siRNA) & slicing Ago partial complementarity (miRNA) target repression mRNA degradation mRNA degradation translational inhibition sequestration decapping complex deadenylation complex target cleavage exonuclease chewing cofactor recruitment Ago GW182

An animated explanation of RNA interference (RNAi) and microRNA-mediated gene regulation.

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