Successfully reported this slideshow.
Your SlideShare is downloading. ×

mobile technologies: riding the hype cycle together

Ad
Ad
Ad
Ad
Ad
Ad
Ad
Ad
Ad
Ad
Loading in …3
×

Check these out next

1 of 61 Ad
Advertisement

More Related Content

Slideshows for you (20)

Viewers also liked (20)

Advertisement

Similar to mobile technologies: riding the hype cycle together (20)

Advertisement

Recently uploaded (20)

mobile technologies: riding the hype cycle together

  1. 1. brian m. bot | principal scientist | 2016 june 06 sage bionetworks ohsu oncology retreat mobile technologies: riding the hype cycle together
  2. 2. sage bionetworks
  3. 3. sage bionetworks promote open systems, incentives, and norms to redefine how complex biological data is gathered, shared, and used our approach
  4. 4. sage bionetworks engage diverse communities of researchers around biological and analytical problems too complex for a single institution our focus empower citizens to track their own health and contribute deep phenotypic data to research topics important to them
  5. 5. CRC Subtyping Consortium DREAM Challenges Progenitor Cell Biology Consortium TCGA Pan-Cancer Consortium CommonMind Consortium PsychENCODE Accelerating Medicines Partnership Resilience Project M2OVE-AD Consortium Dengue Fever LINCS project Oncology Molecular Classifiers Next Gen Scientific Publishing Mozilla Science Labs sage bionetworks
  6. 6. public / private partnership between NIH, 10 biopharmaceutical companies and several non-profit organizations Accelerating Medicines Partnership
  7. 7. ($ Millions) Total Project Total NIH Total Industry Alzheimer’s Disease 129.5 67.6 61.9 Type 2 Diabetes 58.4 30.4 28 Rheumatoid Arthritis 41.6 20.9 20.7 TOTAL 229.5 118.9 110.6 Accelerating Medicines Partnership
  8. 8. Target Discovery Target Discovery Target Discovery Target Discovery Target Validation Target Validation Target Validation Target Validation Shared Information for Target Identification coordinate sharing of early-phase target identification insights Accelerating Medicines Partnership
  9. 9. AMP-AD Collaborative Workspace Quarterly Depositions Broad/ RUSH Mt. Sinai U Fl/ ISB/ Mayo Emory Sage Other Partners Individual Partner Workspaces AMP-AD Data Portal Consortium Space Public space AMP-AD Synapse Project Structure Accelerating Medicines Partnership
  10. 10. CRC Subtyping Consortium DREAM Challenges Progenitor Cell Biology Consortium TCGA Pan-Cancer Consortium CommonMind Consortium PsychENCODE Accelerating Medicines Partnership Resilience Project Dengue Fever LINCS project Oncology Molecular Classifiers Next Gen Scientific Publishing Mozilla Science Labs sage bionetworks M2OVE-AD Consortium
  11. 11. analysis of: 12 tumor types 6 molecular profiling platforms TCGA Pan-Cancer Consortium
  12. 12. 18NPG papers 68core projects 248researchers 28institutions 1070datasets 1723results TCGA Pan-Cancer Consortium
  13. 13. TCGA Pan-Cancer Consortium
  14. 14. CRC Subtyping Consortium DREAM Challenges Progenitor Cell Biology Consortium TCGA Pan-Cancer Consortium CommonMind Consortium PsychENCODE Accelerating Medicines Partnership Resilience Project Dengue Fever LINCS project Oncology Molecular Classifiers Next Gen Scientific Publishing Mozilla Science Labs sage bionetworks M2OVE-AD Consortium
  15. 15. CRC Subtyping Consortium
  16. 16. A B C D E F 1 2 3 4 5 6 expert team data subtype CRC Subtyping Consortium
  17. 17. A B C D E F 1 2 3 4 5 6 ... expert team data subtype CRC Subtyping Consortium
  18. 18. doi:10.1038/nm.3967 doi:10.7303/syn2623706 CRC Subtyping Consortium
  19. 19. sage bionetworks engage diverse communities of researchers around biological and analytical problems too complex for a single institution our focus empower citizens to track their own health and contribute deep phenotypic data to research topics important to them
  20. 20. Healthmobile
  21. 21. Healthm
  22. 22. move beyond insular health tracking
  23. 23. move beyond insular health tracking nearly 200 million smart phone users in US
  24. 24. >75%
  25. 25. how to balance desire to share w/ importance of privacy?
  26. 26. 2013 september
  27. 27. 2015 march
  28. 28. the hype cycle
  29. 29. the hype cyclelaunching
  30. 30. participant-centered consent
  31. 31. changeable by participant
  32. 32. ~75k participants across all studies >70% opted to share broadly
  33. 33. 36 mPower
  34. 34. passive measures gps - displacement vectors gps - displacement vectors - - structured activities tapping activity walking/ standing activity voice activity memory game surveys MDS-UPDRS PDQ8 MDS-UPDRS PDQ8 MDS-UPDRS PDQ8 MDS-UPDRS PDQ8 four symptoms of PD motor initiation gait/balance hypophonia memory
  35. 35. motor initiation gait/balance hypophonia memory mPower activities
  36. 36. x y z userAcceleration gravity rotationRate attitude device motion readings at 100 hz gait / balance
  37. 37. gait / balance
  38. 38. Monty Python's The Flying Circus gait / balance
  39. 39. mPower six month data release 9,520 unique participants 8,320 completed at least one task 198,639 total activities and surveys completed 1,087 self reported parkinson diagnosis
  40. 40. mPower six month data release task name type of task and schedule unique participants unique tasks demographics survey - once 6,805 6,805 MDS-UPDRS survey - monthly 2,024 2,305 PDQ8 survey - monthly 1,334 1,641 memory activity - t.i.d. 968 8,569 tapping activity - t.i.d. 8,003 78,887 voice activity - t.i.d. 5,826 65,022 walking activity - t.i.d. 3,101 35,410
  41. 41. mHealth research communityParkinson
  42. 42. mHealth research communityParkinson
  43. 43. Parkinson’s Disease Foundation Eli Lilly AstraZeneca Apple Verily Intel Infocepts Posit Science MIT The Ohio State University University of Otago University of Texas Health Science Center Istanbul Sehir University University of Iowa University of Virginia University of Toronto Johns Hopkins University Vanderbilt University University of Rochester McGill University Xi'an Jiaotong University University of Washington Harvard University mHealth research communityParkinson
  44. 44. leverage publicly available data incorporate modules into phase I clinical trial w/ custom scheduling initial training / testing done in person follow ups done remotely by participants mHealth research communityParkinson
  45. 45. mHealth research community
  46. 46. riding the hype cycle together
  47. 47. brian m. bot ———————— principal scientist community manager brian.bot@sagebase.org @BrianMBot thank you sage bionetworks
  48. 48. Parkinson mHealth research community
  49. 49. Parkinson mHealth research community
  50. 50. Parkinson mHealth research community
  51. 51. Parkinson mHealth research community

×