LFA-1のグローバルな� ICAM-1! コンフォメーション変化� 7. Ligand binding! 6. Activation of I domain by downward movement of its C- terminal ”pull spring"! 5. Swing-out of hybrid domain and activation of I- like domain! 3. Separation of α and β 4. Switchblade-like upward 1. Cellular tailpieces! movement of headpiece ! activation! α β 2. Binding of factors to Integrin integrin cytoplasmic Integrin binding binding factor! factor! domains !
Cytoplasmic proteins interacting with β integrin tails Legate KR, J Cell Sci 2009
Talin and Kindlin activate integrin Moser M, Science 2009
Talin activates integrin Moser M, Science 2009
Talin activates integrin at the membrane-cytoplasmic interface Moser M, Science 2009
How do Talin and Kindlin act together on integrin? Moser M, Science 2009
Talin and Kindlin can simultaneously bind to the β integrin tail Bass MS, Nat Cell Biol 2011
Which comes first: affinity or avidity? Carman CV, Curr Opin Cell Biol 2003
Puzzles to be solved (1)Biophysical basis of integrin activation: How forceinduces integrin conformational activation?Integrin adhesion dynamism: How integrin activationand inactivation are coordinated?