Network Pharmacology: From          BioAssay Response Data to Network                  Bin Chen, Nikil Wale, Kevin McConne...
Network of top 2% most highly correlated pairs by BARD using Spearman (Node presents assay, two nodes are linked if their ...
Network of top 2% most highly correlated pairs by BARD using SEA (Node presents assay, two nodes are linked if their simil...
5-HT7 & D1common active 536spearman 0.571TC=0.84SEA: 1.2e-25
Network pharmacology: From BioAssay Response Data to Network
Network pharmacology: From BioAssay Response Data to Network
Network pharmacology: From BioAssay Response Data to Network
Network pharmacology: From BioAssay Response Data to Network
Network pharmacology: From BioAssay Response Data to Network
Network pharmacology: From BioAssay Response Data to Network
Network pharmacology: From BioAssay Response Data to Network
Network pharmacology: From BioAssay Response Data to Network
Network pharmacology: From BioAssay Response Data to Network
Network pharmacology: From BioAssay Response Data to Network
Network pharmacology: From BioAssay Response Data to Network
Network pharmacology: From BioAssay Response Data to Network
Network pharmacology: From BioAssay Response Data to Network
Network pharmacology: From BioAssay Response Data to Network
Network pharmacology: From BioAssay Response Data to Network
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Network pharmacology: From BioAssay Response Data to Network

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Network pharmacology, comparing protein pharmacology networks built from Ligand based approach (Similarity Ensemble Approach) with those built from BioAssay response data.

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Network pharmacology: From BioAssay Response Data to Network

  1. 1. Network Pharmacology: From BioAssay Response Data to Network Bin Chen, Nikil Wale, Kevin McConnell and Eric GiffordCite: Bin Chen, Kevin McConnell, Nikil Wale, David Wild, Eric Gifford, Comparing Bioassay Response andSimilarity Ensemble Approaches to Probing Protein Pharmacology, Bioinformatics
  2. 2. Network of top 2% most highly correlated pairs by BARD using Spearman (Node presents assay, two nodes are linked if their similarity reaches certainthreshold. Node is colored by gene family. Solid edges indicate common edges between two networks. Some non obvious links are highlighted in dashedred oval.
  3. 3. Network of top 2% most highly correlated pairs by BARD using SEA (Node presents assay, two nodes are linked if their similarity reaches certainthreshold. Node is colored by gene family. Solid edges indicate common edges between two networks. Some non obvious links are highlighted in dashedred oval.
  4. 4. 5-HT7 & D1common active 536spearman 0.571TC=0.84SEA: 1.2e-25

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