1. Chemogenetics
02
Page 15
List of representative DREADDs.
DREADD Description Ligand
hM3D(Gq) Increase Ca2+, Activation CNO
hM4D(Gi) Decrease cAMP β/γ-GIRK activation, Inhibitory CNO
KORD Decrease cAMP β/γ-GIRK activation, Inhibitory SALB
To activate neuron activity, choose hM3Dq.
To inhibit neuron activity, choose hM4Di.
Fig.7 Mechanism of different variants of DREADDs (hM3Dq and hM4Di).