CSIARTEMISIANNUA8SEPTEMBREDEFINITIF.pptx

Artemisia annua : résultats de
la recherche actuelle
Bernard SUDAN
Conseil Scientifique Indépendant
du 8 septembre 2022
Armoise annuelle, Artemisia annua L.
Tela Botanica, répartition en France
Armoise annuelle, Artemisia annua L.
Sud de la France, Flore des Alpilles
Artemisia annua
Pharmacopée traditionnelle
Artemisia annua
Histoire contemporaine
Artemisia annua, Coronavirus, Ouest-
France, ANSM : 4 mai 2020
ANSM et Artemisia annua
Madagascar dès le début 2020
Madagascar dès le début 2020
Artemisia annua, artémisinine et
paludisme
Artemisia annua, artémisinine
ou plante entière ?
Artemisia annua et académie de médecine
Artemisia annua et afra: plante entière
plus efficace…
Artemisia annua : des résultats
dérangeants
The Lancet 1989: placebo 1 mg nicotine
not retracted !
Artemisia annua, paludisme et artésunate
Artemisia annua: artémisinine et SARS-CoV-2
Application traditionnelle et recherche
pharmacologique moderne d’Artemisia annua
Artemisia annua: Nouvelles perspectives
pour le traitement de diverses maladies.
Artemisia annua: une plante
traditionnelle mise en lumière
Artemisia annua: une plante
traditionnelle mise en lumière
Artemisia annua et effets
hypoglycémiques sur les souris
Artemisia annua: artémisinine contre
SARS-CoV-2
Artemisia annua et protéase du SARS-CoV-2
Frontiers in Medicine, 15 juin 2022
Artemisia annua et SARS-CoV-2: Rhamnocitrine,
isokaempferide, kaempferol
• Les chercheurs de plusieurs pays dont le Nigéria, l’Egypte, l’Arabie
Saoudite et le Brésil ont réussi à partir de 168 molécules d’Artemisia
annua à isoler une molécule, la rhamnocitrine ayant le potentiel le plus
élevé pour inhiber la principale protéase du SARS-CoV-2, suivie par
deux autres molécules l’isokaempferide et du kaempferol.
• Les trois composés, comme le ligand standard, ont occupé le site actif
de Mpro, où ils ont interagi avec d’importants résidus d’acides aminés
comme HIS 41, ASN 142, CYS 145, et GLU 166, entre autres. La
rhamnocitrine s’est révélée stable, avec un mode de liaison unique
dans le site actif de la protéine tout au long de la simulation. Les trois
composés sélectionnés possèdent un profil ADMET favorable et aucun
d’eux n’a montré la tendance à l’hépatotoxicité, la cancérogénicité, la
mutagénicité, la cytotoxicité et l’immunotoxicité. Par conséquent, ces
composés d’Artemisia annua pourraient faire l’objet d’études
expérimentales et d’autres développements dans des médicaments
pour le traitement du SRAS-CoV-2. »
FIGURE 6. Interactions moléculaires de la
rhamnocitrine avec la protéase principale du SARS-
CoV-2
Covid-19, Artemisia annua, COVID-19
Covid-19, Artemisia annua, Madagascar
Mortalité Covid-19 Madagascar vs. France
Artemisia annua, artémisinine et dérivés,
hydroxychloroquine, arténimol contre Covid-19
Artemisia annua : Inhibition de la
réplication du SARS-CoV-2 et variants
Artemisia annua contre variants
Covid-19
Artemisia annua en 2002 contre le SRAS
Artemisia annua : effets anti-
allergiques chez le rat
Activité anti-cancéreuse de
l’artémisinine et ses dérivés
Propriétés anti-cancéreuses des
sesquiterpènes d’Artemisia annua
Artemisia annua, apoptose
et cancer du poumon
Chrysosplenol D, un flavonol de Artemisia
annua, induit l’apoptose des cellules du cancer
du sein humain
Le diplôme d’herboriste supprimé par le
régime de Vichy le 11 septembre 1941
Plantes et utilisation thérapeutique
Covid-19
Plantes et sites d’action anti-SARS-CoV-2
Moringa oleifera: Kaempferol-3-O-rutinoside
and Vitexine contre SARS-CoV-2
Camelia sinensis : Inactivation du SARS-
Cov-2 par le thé noir ou vert
Agglutinine de l’ortie piquante Urtica
dioica contre SARS-CoV-2
Urtica dioica L.: guérison des plaies
Pissenlit Taraxacum officinale contre
SARS-CoV-2
SARS-CoV-2 et efficacité de l’échinacée
pourpre (Echinacea purpurea)
https://www.bernardsudan.net/
Dead Sea salts as a new approach for the treatment
of seborrheic dermatitis
Les sels de la mer Morte comme nouvelle approche
pour le traitement de la dermatite séborrhéique
De 1887 à 2022 : Vers une solution de la
dermite séborrhéique
https://www.nobelprize.org/womenwhoch
angedscience/stories/tu-youyou
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CSIARTEMISIANNUA8SEPTEMBREDEFINITIF.pptx

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