Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.

Cdd mind the health gap 2010 talk.ppt [autosaved]

666 views

Published on

CDD Mind the Health Gap 2010 Presentation by Barry Bunin on technology to mine drug discovery data, secure private-to-private, and private-public collaborations.

Published in: Health & Medicine
  • Be the first to comment

  • Be the first to like this

Cdd mind the health gap 2010 talk.ppt [autosaved]

  1. 1. <ul><li>CDD Strong Community-Based Mission & Values </li></ul><ul><ul><ul><li>Neglected disease and commercial disease are both core components </li></ul></ul></ul><ul><ul><ul><li>Collaborative culture – share successes and failures, as much as possible </li></ul></ul></ul><ul><ul><ul><li>Tap leading community expertise with industry focused process </li></ul></ul></ul><ul><li>Do Groundbreaking Work </li></ul><ul><ul><ul><li>Revolutionary approaches to solving critical health problems </li></ul></ul></ul><ul><ul><ul><li>Imagine what would be possible in an ideal world, practically implement </li></ul></ul></ul><ul><ul><ul><li>Discover drugs while changing the nature of the game </li></ul></ul></ul>Copyright © 2010 All Rights Reserved Collaborative Drug Discovery
  2. 2. CDD aids C ollaborations Result New leads reveal known drugs that reverse chloroquine resistance
  3. 3. CDD Successfully Builds Collaborative Drug Discovery Communities <ul><ul><li>DDT, 2009 (14: 261-270): </li></ul></ul><ul><ul><li>$2. 9M Tuberculosis B&MGF Project </li></ul></ul><ul><ul><li>>6 Years CDD SaaS in the Cloud </li></ul></ul><ul><ul><li>Thousands of scientists engaged: </li></ul></ul>
  4. 4. © 2009 Collaborative Drug Discovery, Inc.
  5. 5. Yes We Can! © 2010 Collaborative Drug Discovery, Inc.
  6. 6. <ul><li>What are the challenges and opportunities for the field? </li></ul><ul><li>How are your priorities changing? </li></ul><ul><li>What are the emerging bottlenecks? </li></ul><ul><li>What if? </li></ul><ul><ul><li>Any technology, any collaborators, if you had a magic wand… </li></ul></ul>Register for GlaxoSmithKline on CDD Public Copyright © 2010 All Rights Reserved Collaborative Drug Discovery
  7. 7. Networks Selectively Collaborating “Public-Private Partnerships” # of [compds][targets][indications][experts] = (xyz)(pdq)(abc)(lmn)
  8. 8. CDD Database for Your Private Data Copyright © 2010 All Rights Reserved Collaborative Drug Discovery
  9. 9. Collaborate Mode 1 – Big Pharma with single login to multiple CROs/Biotech groups Copyright © 2010 All Rights Reserved Collaborative Drug Discovery
  10. 10. Collaborate Mode 2 – Peer-to-Peer: Any Data via Any Query Can Be Securely Shared CDD DB group 1 CDD DB group 2 CDD DB group 3 CDD DB group 4 Copyright © 2010 All Rights Reserved Collaborative Drug Discovery
  11. 11. <ul><li>What are the challenges and opportunities for the field? </li></ul><ul><li>How are your priorities changing? </li></ul><ul><li>What are the emerging bottlenecks? </li></ul><ul><li>What if? </li></ul><ul><ul><li>Any technology, any collaborators, if you had a magic wand… </li></ul></ul>Questions for our Field Copyright © 2010 All Rights Reserved Collaborative Drug Discovery
  12. 12. Where CDD Adds Value – Moving top Drug Leads Forward CDD moves top leads forward Value Academics + CDD $0.1M $1M $10M $5M $0.3M Enzymatic Assays Cell Based Functional Assays Animal Efficacy Tox/PK Academic Early Drug Leads -1 yr -2 yr 2 yr Med Chem Lead Optimization 1 yr <ul><li>CDD better than money alone </li></ul>Billion $ Examples: Taxol
  13. 13. <ul><li>1. Spend only 20% on descriptors and algorithms </li></ul><ul><li>2. Selectively share your models with collaborators and control access </li></ul><ul><li>3. Have someone else host the models / predictions </li></ul>What if you could… Copyright © 2010 All Rights Reserved Collaborative Drug Discovery Models Inside company Collaborators Commercial Descriptors Algorithms ADME/Tox data Current investments >$1M/yr >$10-100’s M/yr
  14. 14. Yes we can…predictions now can be shared without revealing structures!
  15. 15. The future: Alerts in CDD
  16. 16. CDD Platform <ul><li>Modules: </li></ul><ul><ul><li>CDD Vault – Secure place for private data – private by default </li></ul></ul><ul><ul><li>CDD Collaborate – Selectively share subsets of data </li></ul></ul><ul><li>Datasets: </li></ul><ul><ul><li>CDD Public – expanding public data sets </li></ul></ul><ul><ul><ul><li>published compounds </li></ul></ul></ul><ul><ul><ul><li>data from community members </li></ul></ul></ul><ul><ul><ul><li>vendor libraries </li></ul></ul></ul><ul><ul><li>Unique to CDD – simultaneously query your private data, collaborators’ data, & public data </li></ul></ul>Copyright © 2010 All Rights Reserved Collaborative Drug Discovery
  17. 17. Securely Zoom in-and-out of Private, Collaborative, and/or Public Vaults (Data) © 2009 Collaborative Drug Discovery, Inc.
  18. 18. <ul><li>Back Pocket </li></ul>Telescopic View of Multiple Vaults & Data Sets © 2010 Collaborative Drug Discovery, Inc.
  19. 19. Simultaneously Search All Vaults & Data Sets: Gets You “Outside the Box” © 2010 Collaborative Drug Discovery, Inc.
  20. 20. New Types of Offerings for a Rapidly Changing Industry <ul><li>CDD Community: tap into global R&D via “crowd-sourcing” </li></ul><ul><li>CDD Alliance: better management of your collaborations </li></ul><ul><li>CDD Customize: fast, good, and cost-effective = agile </li></ul>Use CDD Vault™, Collaborate™, Public™ for Global R&D Community
  21. 21. Acknowledgements Copyright © 2010 All Rights Reserved Collaborative Drug Discovery <ul><li>Industry : Eli Lilly & Co., GlaxoSmithKline, Pfizer </li></ul><ul><li>Foundations : Bill & Melinda Gates Foundation, Myelin Repair Foundation </li></ul><ul><ul><li>Initial TB pilot laboratories </li></ul></ul><ul><li>Academics : CDD Researcher Community </li></ul><ul><ul><li>1000s of CDD collaborators from academia, foundations and industry </li></ul></ul><ul><li>CDD : …including ChemAxon Tools under the hood </li></ul><ul><li>Sean Ekins, PhD, DSc (Collaborations Director – Philadelphia) </li></ul><ul><ul><li>Pfizer, Lilly, Concurrent Pharmaceuticals, GeneGo </li></ul></ul><ul><li>Moses Hohman, PhD (VP Software Development – Chicago) </li></ul><ul><ul><li>Northwestern Assoc. Director of Bioinformatics, Thoughtworks, Inc., U of Chicago (PhD), Harvard ( magna cum laude, Physics) </li></ul></ul><ul><li>Sylvia Ernst, PhD (Senior Director Community Growth – Oregon) </li></ul><ul><ul><li>Accelrys-Scitegic, MDL </li></ul></ul><ul><li>Andrea Barry (Senior Director Business Dev – N. Carolina) </li></ul><ul><ul><li>Accelrys-Scitegic, MDL </li></ul></ul><ul><li>Kellan Gregory (Head Community Interests Group – California ) </li></ul><ul><ul><li>Anna Spektor (Community Advocate, ex-IDBS) </li></ul></ul>
  22. 22. <ul><li>Start with Strong Mission & Values </li></ul><ul><ul><ul><li>Neglected disease and commercial disease are both core components </li></ul></ul></ul><ul><ul><ul><li>Collaborative culture – share successes and failures, as much as possible </li></ul></ul></ul><ul><ul><ul><li>Tap leading community expertise with industry focused process </li></ul></ul></ul><ul><li>Do Groundbreaking Work </li></ul><ul><ul><ul><li>Revolutionary approaches to solving critical health problems </li></ul></ul></ul><ul><ul><ul><li>Imagine what would be possible in an ideal world, practically implement </li></ul></ul></ul><ul><ul><ul><li>Discover drugs while changing the nature of the game </li></ul></ul></ul><ul><ul><ul><li>What if…you had a magic wand? </li></ul></ul></ul>Copyright © 2010 All Rights Reserved Collaborative Drug Discovery Answers for Our Field
  23. 23. CDD Collaborative Drug Discovery, Inc. Burlingame, CA www.collaborativedrug.com Barry A. Bunin, PhD CEO & President [email_address] Archive, Mine, Collaborate ®
  24. 24. CDD3 Data Mapper: Intuitive Templates and Previews Simplify Archival Copyright © 2009 All Rights Reserved Collaborative Drug Discovery
  25. 25. CDD Projects – More Advanced Collaborate
  26. 26. Collaborative Dashboard for Secure To-the-Minute Global R&D Tracking Copyright © 2010 All Rights Reserved Collaborative Drug Discovery
  27. 27. CDD Case Study: Create a Globally Connected TB Researcher Community <ul><li>TB Literature and Patent SAR: > 125,000 public TB Bioassay data points for all researchers to use </li></ul><ul><li>20 pilot user groups oversubscribed </li></ul><ul><li>5 consortium actively utilizing CDD software for TB research </li></ul><ul><li>Implemented scalable policy for worldwide use (free software, paid services)…beyond the Bill & Melinda Gates Foundation project </li></ul>
  28. 28. CDD database system <ul><li>Web based (log in securely into to your database from any computer). </li></ul><ul><li>We host the server for you (SaaS) </li></ul><ul><li>Highly secure, all traffic encrypted, server in a secure professionally hosted environment. </li></ul>Secure and Low TCO (Total Cost of Ownership) Copyright © 2010 All Rights Reserved Collaborative Drug Discovery
  29. 29. CDD database system: Security overview <ul><li>CDD encrypts all traffic between a user's web browser and our servers once the user has logged in. </li></ul><ul><li>CDD does thorough automated testing of our application code, including security tests to make sure one group cannot access another group's private data. </li></ul><ul><li>CDD uses two levels of firewalling (&quot;defense in depth&quot;), hardware and software, for each sensitive server in our server environment. </li></ul><ul><li>CDD encrypts all database and customer file backups using public key cryptography, and the private keys are backed up securely. </li></ul><ul><li>CDD stores user passwords in our database using strong, one-way encryption hashes. </li></ul><ul><li>CDD stays current with all security updates to our system software, firmware and operating systems. </li></ul><ul><li>CDD uses Linux systems in production. </li></ul><ul><li>A number of application security enhancements around password security are being made mandatory. </li></ul><ul><li>Access to production servers and superuser accounts is limited and audited within CDD. </li></ul>Copyright © 2010 All Rights Reserved Collaborative Drug Discovery
  30. 30. Fundamentally Faster Rate of Innovation Copyright © 2010 All Rights Reserved Collaborative Drug Discovery
  31. 31. CDD Search Results View Copyright © 2010 All Rights Reserved Collaborative Drug Discovery
  32. 32. Super Simple Scatter Plots
  33. 33. Heat Maps, Controls, & Plate Statistics Copyright © 2010 All Rights Reserved Collaborative Drug Discovery

×