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Omega 3 fatty acid for canser privention 1


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Omega 3 fatty acid for canser privention 1

  1. 1. W.M.I.S.B.Panampitiya Department of Food Science and Technology Faculty of Agriculture University of Peradeniya
  2. 2. • Omega-3 FA’s are polyunsaturated, meaning they contain more than one double bond • They are called omega-3, because the first double bond counting from the methyl end of the fatty acid is located at the third carbon atom
  3. 3.  Alpha-linolenic acid (ALA)  Eicosapentaenoic acid (EPA)  Docosahexaenoic acid (DHA)
  4. 4.  The first part (18:3) suggests that ALA is an 18-carbon fatty acid with 3 double bonds  The second part (n-3) tells you that ALA is an omega-3 fatty acid  It is required for health, but cannot be synthesized in humans  ALA is considered a plant-derived omega-3 fatty acid
  5. 5.  Humans can synthesize other omega-3 fatty acids from ALA:  Eicosapentaenoic acid (EPA): 20:5n-3  Docosahexaenoic acid (DHA): 22:6n-3 • Found in very high concentrations in the cell membranes of the retina • This consider as a marine- derived omega-3 fatty acid
  6. 6. •Canola oil •Fish liver oils, Fish eggs •Human Milk •Organ meats •Fish : salmon, tuna, halibut, shrimp, cod, sardines, halibut •Other seafood : algae and krill •Plants : soybeans, tofu, kale, collard greens, winter squash •Nut oils : flax seeds and walnuts
  7. 7.  May suppress the growth of existing cancers and may prevent or slow metastasis  May increase the efficacy of chemo- or radiation therapy  Hormone responsive tumors such as: breast, prostate and colon cancers seem especially sensitive to omega 3 fatty acids.
  8. 8.  Marine-derived fatty acids have been found to inhibit proliferation and promote apoptosis in breast, prostate, and colon cancer cell lines cultured outside the body  Studies in animal models of cancer also indicate that increased intake of EPA and DHA decreases the occurrence and progression of mammary, prostate, lung cancer and intestinal tumors
  9. 9. • Slowing cancer cell mitosis • Increasing cancer cell death • Altering estrogen metabolism • Inducing differentiation • Suppressing angiogenesis
  10. 10.  EPA and DHA decreased mitosis and inhibited growth of breast and colon cancer cells • Apoptosis is programmed cell death. • When apoptotic pathways are functional, cells with unreparable genetic damage should die. • However, apoptotic pathways are frequently disrupted in cancers.
  11. 11.  Terminally differentiated cells do not multiply. n-3 fatty acids have been shown to induce differentiation of breast cancer cells • Shift in estrogen metabolism towards 16a- hydroxylation increases the formation of proliferation in breast cells. Omega-3 supplements decreased 16a- hydroxylation
  12. 12.  The growth of new blood vessels, must occur for cancers to grow  The n-3 products of cyclooxygenase do not stimulate angiogenesis
  13. 13.  consumption of an n-3 supplement for 3 months significantly changed composition of breast adipose tissue • Eating foods rich in omega-3 fatty acids seems to reduce the risk of colorectal cancer. n–3 fatty acids accumulate in biological membranes and may initiate signal-transduction processes or modify membrane structure.
  14. 14.  There is some epidemiological support for a protective effect of n−3 fatty acids on prostate cancer. • Fish or fish oil consumption will reduced risk of lung cancer
  15. 15.  The source of some omega-3 fatty acids may be a health concern.  People who are allergic to fish may have serious reactions to fish oil.