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MEMBRANE TRANSPORT
 
 
 
 
 
Overview of membrane transport proteins
Uniporter-catalyzed transport <ul><li>Uniporters accelerate a reaction that is already thermodynamically favored (similar ...
A comparison of the uptake rate of glucose by facilitated diffusion and passive diffusion
An example uniporter
Subunit composition of the Na + /K +  ATPase
Proposed model for operation of the two-Na + /one-glucose symporter
Transport across epithelia: the intestinal epithelium is highly polarized
Transepithelial movement of glucose and amino acids requires multiple transport proteins
Tight junctions seal off body cavities and restrict diffusion of membrane components
Bulk transport: Endocytosis (Pinocytosis, Phagocytosis)
Receptor-Mediated Endocytosis
Protein structure determines function <ul><li>Proteins are single, unbranched chains of amino acid monomers </li></ul><ul>...
All amino acids have the same general structure but the side chain (R group) of each is different
Hydrophilic amino acids
Hydrophobic and “special” amino acids
Peptide bonds connect amino acids into linear chains
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4. suppl. membrane transport 2

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4. suppl. membrane transport 2

  1. 1. MEMBRANE TRANSPORT
  2. 7. Overview of membrane transport proteins
  3. 8. Uniporter-catalyzed transport <ul><li>Uniporters accelerate a reaction that is already thermodynamically favored (similar to enzymes) </li></ul><ul><li>This type of transport is termed facilitated transport or facilitated diffusion </li></ul><ul><li>Three main features distinguish uniport transport (facilitated diffusion) from passive diffusion </li></ul><ul><ul><li>The rate of facilitated diffusion is much higher than passive diffusion </li></ul></ul><ul><ul><li>Transport is specific </li></ul></ul><ul><ul><li>Transport occurs via a limited number of uniporters </li></ul></ul>
  4. 9. A comparison of the uptake rate of glucose by facilitated diffusion and passive diffusion
  5. 10. An example uniporter
  6. 11. Subunit composition of the Na + /K + ATPase
  7. 12. Proposed model for operation of the two-Na + /one-glucose symporter
  8. 13. Transport across epithelia: the intestinal epithelium is highly polarized
  9. 14. Transepithelial movement of glucose and amino acids requires multiple transport proteins
  10. 15. Tight junctions seal off body cavities and restrict diffusion of membrane components
  11. 16. Bulk transport: Endocytosis (Pinocytosis, Phagocytosis)
  12. 17. Receptor-Mediated Endocytosis
  13. 18. Protein structure determines function <ul><li>Proteins are single, unbranched chains of amino acid monomers </li></ul><ul><li>There are 20 different amino acids </li></ul><ul><li>A protein’s amino acid sequence determines its three-dimensional structure (conformation) </li></ul><ul><li>In turn, a protein’s structure determines the function of that protein </li></ul>
  14. 19. All amino acids have the same general structure but the side chain (R group) of each is different
  15. 20. Hydrophilic amino acids
  16. 21. Hydrophobic and “special” amino acids
  17. 22. Peptide bonds connect amino acids into linear chains

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