Mechanism of action
Disease related .
GABA acts at inhibitory synapse in the brain by binding to
specific transmembrane receptor in the plasma membrane of
both pre- and postsynaptic neuronal processes.
It is most highly concentrated in the substantia nigra &
globus pallidus nuclei of the basal ganglia, followed by
the hypothalamus, the periaqueductal grey matter.
Activation of presynaptic GABA-B receptors decreases
the release of GABA and of different transmitters.
Activation of postsynaptic GABA-B receptors
modulates the opening of potassium channels, which
induces an intracellular potassium exit and
consequently a membrane hyperpolarisation.
Relieving premenstrual syndrome (PMS).
Regulating the release of sex hormones.
Deficiency of GABA
It has been suggested that a shortage
of GABA may cause panic attacks,
since an intake of tranquilizers can
increase the level of GABA in the
body. GABA may also be effective in
treating PMS in women.
Health problems can GABA Deficiency cause
low levels of
GABA is an amino acid made in brain cells from
glutamate. It functions as an inhibitory
neurotransmitter, meaning it blocks nerve
impulses. Without GABA, nerve cells fire too
often and too easily.