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InMed Pharmaceuticals


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R&D Biopharmaceutical Company

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InMed Pharmaceuticals

  2. 2. FORWARD LOOKING STATEMENTS This presentation contains forward-looking statements, including statements concerning anticipated clinical development activities, the potential benefits of product candidates and anticipated market opportunities. All statements other than statements of historical fact are statements that could be deemed forward-looking statements. These statements are based on management's current expectations and beliefs and are subject to a number of risks, uncertainties and assumptions that could cause actual results to differ materiallyfrom those described in the forward-looking statements. These risks and uncertainties include, among others, the possibility that clinical trials will not be successful, or be completed, or confirm earlier clinical trial results, risks associated with obtaining funding from third parties, risks related to the timing and costs of clinical trials and the receipt of regulatory approvals. Readers are cautioned that the foregoing list is not exhaustive. For additional information with respect to risks and uncertainties, prospective investors should carefully review and consider the risk factors described under the section “Risk Factors” in the Company’s annual informationform dated March 24, 2017, a copy of which is available on SEDAR at and under the section “Risk Factors” in the short form prospectus. The company undertakes no obligation to update the forward-lookingstatements contained herein or to reflect events or circumstances occurring after the date hereof. CSE:IN OTCQB:IMLFF2
  3. 3. 3 OVERVIEW InMed is a publicly listed, Vancouver-based biopharmaceutical company focused on identifying, developing and commercializing prescription drugs using non-THC cannabinoids. Core Assets Bioinformatics Database Proprietary computer-based drug/disease target screening tool Biosynthesis Proprietary cannabinoid manufacturing system Drug Development Pipeline Expedited drug development timelines,conservative clinical budget targeting high unmet medical conditions utilizing disease-specific formulations: Ø INM-750 for Epidermolysis Bullosa – An orphan paediatric disease characterized by extremely fragile skin with no current approved therapies. Potential global market revenues of ~US$1B. Ø INM-085 for Glaucoma – Aserious eye disease with a global market of >US$5B.
  4. 4. e The endocannabinoid receptor system is a group of endogenous cannabinoid receptors located in the mammalian brain, throughout the central and peripheral nervous systems, and in tissues and organs. This system is predisposed to interact with any member of the cannabinoid drug family. HEALING POWER OF CANNABINOIDS 4 90+ Individual Cannabinoid Chemicals THC CBD +8 80+ Cannabinoids EACH CHEMICAL AFFECTS THE HUMAN BODY Endocannabinoid Receptor System
  5. 5. BIOINFORMATICS: Proprietary Drug/Disease Targeting Tool InMed’s proprietary bioinformatics algorithm assesses the different active sites on cannabinoids and screens them against approved drug structures, disease site receptors, genetic profiles of diseases, and the involvement of proteins and chemical metabolites in disease pathways. This program then selects specific cannabinoids (or combinations thereof) that might play a role in regulating diseases. Advantages of InMed’s Bioinformatics Tool Ø Generates new therapies both quickly and effectively - significant cost and time savings in the drug discovery process. Ø Allows InMed to research pharmacological responses of ALL90+ cannabinoids. Ø Has already identified multiple therapies includingInMed’s INM-750& INM-085. 5
  6. 6. BIOSYNTHESIS: PROPRIETARY CANNABINOID MANUFACTURING Cannabinoid Genomic DNA Escherichia coli cell Benefits of Biosynthesis Enhanced Production, Purification and QC vs. current synthetic production methods Significant cost savings vs. existing growing / harvesting / extraction / purification methods Access to minor cannabinoidsthat are currently economically unfeasible to develop into drugs Increased structural integrity vs.chemical manufacturing methods Millions of diabetics worldwide use synthetic insulin produced via E.coli biosynthesis. 6
  7. 7. DRUG DEVELOPMENT: Lead Therapeutic Programs (estimated timelines) * Timelines dependant on, among other things, availability of capital. ** Potential partnership / spin-out opportunities. TherapeuticArea Discovery Target Selection Pre-Clinical, Formulation Clinical Trials Ph1 Ph2b Ph3 Dermatology INM-750 (Epidermolysis bullosa) 2017 2018 * 2019 * 2020 Ocular INM-085 (Glaucoma) 2017 * ** * ** * ** Pain Program INM-405 2017 * * * ** 7
  8. 8. EPIDERMOLYSIS BULLOSA INM-750 No approved treatments for EB InMed’s lead product, INM-750 has many mechanisms-of-actionin the skin to deliver symptomatic relief: Ø accelerated wound healing Ø pain reduction Ø itch reduction Ø reduce inflammation Ø antimicrobial activity INM-750 may re-establish the epidermal / dermal junction by upregulation of specific keratins in the skin, essentially reversing the disease. ~50K patients in N. America, Europe and Japan 8
  9. 9. EPIDERMOLYSIS BULLOSA Acquisition of Scioderm by Amicus for US$847M Ø Scioderm’s sole clinical asset is ZorblisaTM , a Ph3 product in development for EB Ø Scioderm was acquired by Amicus in Sept ‘15 for US$847M (US$229M upfront, US$361M on clin/reg milestones, US$257M on sales milestones) Ø Acquisition was based on results from 42 patients in a Ph2b study Ø JP Morgan and Cowen research reports estimate peak sales for ZorblisaTM in EB of US$900M - US$1.2B Acquisition of Lotus Tissue Repair by Shire for US$174M Ø Lotus Tissue Repair had a preclinical program developing recombinant human collagen Type VII (“rC7”) as a protein replacement therapy for Dystrophic EB, a subset (~30%) of EB patients Ø In February 2013 Shire acquired Lotus Tissue Repair for a fair value consideration totalled US$174M: US$49M upfront; fair value of contingent consideration of US$125M 9
  10. 10. >US$5B worldwide market ~80M patients by 2020 GLAUCOMA: INM-085 Serious Eye Disease Leading to Blindness Dual Mechanism of Action Ø Reduces the intraocular pressure (IOP) in the affected eyes; and Ø Provide neuroprotection for the retinal ganglion cells (RGCs) and other optic nerve tissues in the affected eyes. Proprietary Delivery System Ø INM-085 utilizes a proprietary 1x per day hydrogel formulation to address the major issues of non-compliance (side effects, dosing frequency and adherence). Ø Preclinical animal data showed enhanced penetration of cannabinoid molecules through the cornea and lens compared to control. 10
  11. 11. 11 INM-085 increases blood vessel diameter in pre-clinical mice model Ø Optical CoherenceTomographyscan of a mouse retina(left untreated& righttreated) showed anincreaseof bloodvesseldiameter after 30 min of application. Ø Increaseblood vessel diameter is associated with loweringof IOP. Ø Applicationof treatmentin right eye didn’t effectthe left, thus indicating local effectof INM-085andnot systemic.
  12. 12. 12 R&D Pipeline Therapeutic Area Discovery / DiseaseTarget Selection Target Validation (in vitro/vivo) Formulation / Advanced Preclinical Clinical Ph 1 Dermatology (Orphan) - Epidermolysis Bullosa - Epidermolytic Ichthyosis - Pachyonychia Congenita 2018* Pain / Inflammation - Muscle Pain - NeuropathicPain - Joint Pain 2018* 2019-20* Ocular - Glaucoma 2018* [Partner] Fibrosis - COPD TBD [Partner] Neurodegenerative - Huntington’s TBD [Partner] Cancer - Breast Cancer TBD [Partner] INM-750 INM-085 INM-400 Series INM-300 Series INM-100 Series INM-200 Series *Estimated timing dependent on, among other things, availability of capital.
  13. 13. Priorities & Milestones 2017* 13 Ø INM-750 in Epidermolysis Bullosa Ø Commence Formulation Development - 2Q Ø Complete Formulation Development - 3Q Ø Toxicology studies initiated - 3Q Ø Engage Regulatory Authorities - 4Q Ø INM-085 for Glaucoma Ø Finalize 1x day Hydrogel - 3Q Ø Animal Studies/ IOP Reduction - 3Q Ø Commence Partnering Initiatives - 4Q Ø Biosynthesis Scale-up (50 L) - 3Q Ø Multiple Patent Filings - 2Q-4Q *Estimated timing dependent on, among other things, availability of capital.
  14. 14. EXPERIENCED MANAGEMENT TEAM Eric A.Adams CEO + President 25+ years’ experience in global biopharmaceutical business development, Sales, Marketing, M&A with enGene, QLT, Advanced Tissue Sciences,Abbott Laboratories, Fresenius AG Dr. Sazzad Hossain Chief Scientific Officer, PhD, M.Sc. 20+ years of academic/industry experience in drug discovery and product development at Xenon Pharmaceuticals, targeting pain, inflammation and cardiovascular diseases; and Canada’s National Research Council Dr.Ado Muhammad Chief Medical Officer, MD, DPM, MFPM Former Associate Medical Director at GW Pharmaceuticals specializing in the development of cannabinoid-based prescription medicines Alexandra Mancini Sr. Vice President, Clinical and RegulatoryAffairs, M.Sc. 30 years’ global biopharmaceutical R&D experience with Sirius Genomics, Inex Pharmaceuticals, and QLT Inc. 14 Jeff Charpentier Chief Financial Officer + Corporate Secretary 25+ years’ experience in biotech and technology companies including Lifebank Corp., Inex Pharmaceuticals, and Chromos Molecular Systems Inc.
  15. 15. Andrew Hull , VPof Global Alliances at Takeda Pharmaceuticals 30+ years’pharma/biotech commercial leadership experience. Previously in various roles with Immunex andAbbott Labs. Two-term Chairman of Illinois Biotech Industry Organization. Adam Cutler, SVPof CorporateAffairs atArbutus Biopharma 19+ years of experience in Equity Research, CorporateAffairsand Strategy, Investor Relationsand Consulting. Previously The Trout Group LLC, Credit Suisse, Canaccord Genuity, JMPSecurities, BoASecurities, and The Frankel Group and E&YHealthcare Consulting. Martin Bott, VPFinance and Investment Banking at Eli Lilly & Company 34+ experience in Finance, Investment Banking and Operations in the global pharmaceutical industry. Previous roles include CFO of Diabetes and Global Manufacturing Units; stints in CH, D, UK. Eric A.Adams, President + CEO BOARD OF DIRECTORS 15 William Garner, MD Chairman Founder of EGBAdvisors PR LLC Chairman/Founder of Race Oncology(ASX:RAC); Formerly Director +/- Executive at IGXBio; Invion Limited (ASX:IVX); Del Mar Pharma (NASDAQ: DMPI); Hoffmann LaRoche and healthcare merchant banking in NYC.
  16. 16. CAPITAL STRUCTURE Symbol CSE: IN OTCQB: IMLFF Share I/O 1 Warrants 1 Options 1 Fully-Diluted 1 Market Capitalization 1 127.5 Million 9.6 Million 15.1 Million 152.2 Million 2 $52.3 Million 1 As of May 31, 2017 2 Management & Insiders ~20% ownership CSE:IN OTCQB:IMLFF 16 Cash / Working Capital 1 $8.5 Million
  17. 17. INVESTMENT HIGHLIGHTS Broad portfolio of assets in dermatology, ocular diseases,additional indications and cannabinoid biosynthesis Ø Positioning to achieve value-driving, near-term milestones with limited investment: Ø Lead drug candidate in an orphan paediatric disease with high unmet medical need; final formulation development, toxicology and Ph1-2a clinical trials targeted for completion within 24 months from financing Ø Biosynthesis of cannabinoids aimed to be commercial- ready within 24 months from financing Experienced team capable of building value in biopharmaceuticals CSE:IN OTCQB:IMLFF 17
  18. 18. THANK YOU! InMed Pharmaceuticals Inc. Eric A.Adams, President & CEO Chris Bogart, SVPInvestor Relations #350-409 Granville Street, Vancouver, BC Canada, V6C 1T2 Tel: +1.604.669.7207 Fax: +1.604.683.2506 CSE:IN OTCQB:IMLFF 18