Sectors Of The National And Global Economy Including Textiles


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  • Introduction. Anesthesiology – multidisciplinary with chemistry, engineering, and others. Creation of functional materials, devices, and systems to control of matter on the nanometer (1-100 nm) length scale and exploitation of novel properties and phenomena developed at that scale .
  • Sectors Of The National And Global Economy Including Textiles

    1. 1. Medical Applications of Nanotechnology Timothy E. Morey, M.D. Associate Professor of Anesthesiology University of Florida
    2. 2. How small is nano? E. Corcoran. The Next Small Thing. Forbes Magazine , 07/23/01 Decade: 1/3 rd second Acre: 1/100 th square inch $151,700: 1/100 th cent Scale: Nanoscale
    3. 3. Nanotechnology Growth S. Milunovich, J. Roy. United States Technology Strategy. Merrill Lynch. 4 Sept. 2001
    4. 4. Smart Nanostructures for Selective Drug Delivery <ul><li>Drug Delivery for: </li></ul><ul><li>#1 - Cardiovascular disease </li></ul><ul><li>#2 – Cancer </li></ul><ul><li>#3 - Infectious diseases </li></ul><ul><li>Toxin Removal for: </li></ul><ul><li>Adverse drug reactions >106,000 deaths/yr </li></ul><ul><li>Pesticide Poisonings >220,000 deaths/yr </li></ul>Video Clip Scale: 1/40 th of red blood cell Nanotube Nanocap
    5. 5. NanoMedical Diagnostics <ul><li>Targets: </li></ul><ul><ul><li>- drug overdose </li></ul></ul><ul><ul><li>- brain trauma </li></ul></ul><ul><ul><li>- disease markers </li></ul></ul><ul><li>Where: </li></ul><ul><ul><li>- hospital </li></ul></ul><ul><ul><li>- law enforcement </li></ul></ul><ul><ul><li>- homeland security </li></ul></ul>
    6. 6. Why the University of Florida? <ul><li>Comprehensive university on a compact campus </li></ul><ul><li>Institutional support and priority (2002) </li></ul><ul><ul><li>“… biotechnology, particularly at the interface of medicine and nanoscience.” </li></ul></ul><ul><li>Interdisciplinary faculty with critical mass and focus </li></ul><ul><li>Active OTL partner with a biotechnology incubator </li></ul>
    7. 7. NanoMedical Research Center <ul><li>Vision: Create and harness nano-structured material technologies for the prevention, detection and treatment of diseases in order to enhance the public health and to expand the Florida and national economies </li></ul><ul><li>Focus: Develop nanostructures for medical diagnostics and therapeutics </li></ul><ul><li>Funding: State of Florida Centers of Excellence </li></ul><ul><li>$19.9 million for FY2003-07 with milestones </li></ul><ul><li>Product: Knowledge / Publications / Translational Science Prototypes and IP for OTL licensure </li></ul>
    8. 8. Additional Slides to Answer Questions
    9. 9. MIT Institute for Soldier Nanotechnologies <ul><li>Vision: lighter, faster, more agile force using nanotech. </li></ul><ul><li>Focus: use nanotechnology to dramatically improve the survival and lethality of soldiers </li></ul><ul><li>Faculty: 40 faculty in eight academic departments >100 students and postdocs 11 supportive staff members </li></ul><ul><li>Funding: United States Army </li></ul><ul><ul><ul><li>5 year, $50 million grant beginning FY2002 </li></ul></ul></ul><ul><li>Product: create a battlesuit that combines high-tech capabilities with light weight and comfort </li></ul>
    10. 10. What is nanotechnology <ul><li>Creation of functional materials, devices, and systems. </li></ul><ul><li>Control of matter on the nanometer (1-100 nm) length scale. </li></ul><ul><li>Exploitation of novel properties and phenomena developed at that scale. </li></ul>
    11. 12. What is nano? nanos: dwarf nano 10 -9 mikros: small micro 10 -6 milli: thousand milli 10 -3 chilioi: thousand kilo 10 3 megas: large mega 10 6 gigas: giant giga 10 9 teras: monster tera 10 12 Origins Prefix Power
    12. 13. Why is the nanometer scale different? <ul><li>The wavelike properties of electrons inside matter are influenced by variations on the nanometer scale. </li></ul><ul><li>The systematic organization of matter on the nanometer length scale is a key feature of biological systems. </li></ul><ul><li>Nanoscale components have very high surface areas. </li></ul><ul><li>The finite size of material entities, determine an increase of the relative importance of surface tension and local electromagnetic effects. </li></ul><ul><li>The interaction wavelength scales of various external wave phenomena become comparable to the material entity size. </li></ul>
    13. 14. &quot;There's plenty of room at the bottom.&quot;  <ul><li>Richard P. Feynman, Ph.D. </li></ul>
    14. 15. Nanotechnology Applications <ul><li>stain resistant textiles </li></ul><ul><li>information recording layers </li></ul><ul><li>adaptive camouflage </li></ul><ul><li>body armor </li></ul><ul><li>high hardness cutting tools </li></ul><ul><li>chemical and bio-detectors </li></ul><ul><li>advanced drug delivery systems </li></ul>
    15. 16. Who else is interested? <ul><li>Rensselaer Polytechnic Institute (Troy, NY) </li></ul><ul><ul><ul><li>focus on physical nanotechnology </li></ul></ul></ul><ul><li>Rice University (Houston, TX) </li></ul><ul><ul><ul><li>focus on environment and carbon nanotubes </li></ul></ul></ul><ul><li>Cornell University (Ithaca, NY) </li></ul><ul><ul><ul><li>origins in materials engineering </li></ul></ul></ul><ul><ul><li>University of Michigan (Ann Arbor, MI) </li></ul></ul><ul><ul><ul><li>invested in therapeutics </li></ul></ul></ul>
    16. 17. Why Florida?
    17. 18. Why Nano-Medical in Florida? <ul><li>Targets key industries in Florida </li></ul><ul><ul><li>Pharmaceuticals </li></ul></ul><ul><ul><li>Analytical Instruments </li></ul></ul><ul><ul><li>Medical Devices </li></ul></ul><ul><li>3 of the 10 highest wage Florida industries </li></ul><ul><li>3 times as many jobs exist in these industries as in Florida’s IT industries </li></ul>Florida – Profile of the State Economy; M. Porter; Harvard Business School; Prepared for Gov Bush; 2002
    18. 19. State of Florida Center of Excellence <ul><li>State of Florida </li></ul><ul><ul><li>$30 million for 2-5 Centers of Excellence </li></ul></ul><ul><ul><li>Grants solicited in 2002 for FY2003 commencement </li></ul></ul><ul><li>NanoMedical Research Center </li></ul><ul><ul><li>Focused on nanomedical therapeutics and diagnostics </li></ul></ul><ul><ul><li>Collaboration of chemists, engineers, medical researchers </li></ul></ul><ul><ul><li>Requested $20 million </li></ul></ul><ul><li>Ranked 3 rd of 16 applicant centers </li></ul><ul><ul><li>Awards: UCF, UF (regenerative medicine), FAU </li></ul></ul>
    19. 20. UF Strategic Plan: Priority Areas <ul><li>Cancer and Genetics </li></ul><ul><li>Research on the Brain </li></ul><ul><li>Biotechnology – Interface of Medical Science and Nanoscience </li></ul><ul><li>Aging </li></ul><ul><li>Children and Families </li></ul><ul><li>Ecology/Environment </li></ul>
    20. 21. UF Unique Capabilities - Programs
    21. 22. Deliverables Pipeline Pesticide detoxification Drug detox Bacteriorhodopsin-based data storage Microemulsion formulation technology Biophotonics-based detection of disease Nanoengineered pulmonary drug delivery systems Knowledge of bio-nano toxicity Nanosensors for management of traumatic brain injury Smart nanostructures for targeted drug delivery 2003 2005 2009 2004 2006 2007 2008 Breath detection of drugs Breath detection of diseases Flexible device/system integration Deliverables Chip-based drug delivery system
    22. 23. Milestones: Diagnostics <ul><li>Incorporate reporter molecule into nanotubes </li></ul><ul><li>Decorate surface with appropriate targeting </li></ul><ul><li>Couple target recognition with uncapping </li></ul><ul><li>Detect reporter molecule in blood and breath </li></ul><ul><li>Use in diseased animal model </li></ul><ul><li>Use in cells lines of cancer </li></ul>