Justifications for invasive experiments on animals rely on claims that such research is essential for the advancement of biomedical knowledge, for the development of cures to human diseases, or for the evaluation of the toxicity of compounds to which humans are exposed. Until recently, critical evaluations of the accuracy of such claims have been rare. However, a growing body of large-scale systematic reviews have now been published in scientific and medical journals. The outcomes have been consistent: animal experiments have contributed far less than advocates would have us believe. This presentation summarises these recent results, and comprehensively reviews the alternatives to invasive animal use with biomedical research, toxicity testing, and education. Published studies are available at www.AnimalExperiments.info.