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AP0732 Rev A (07/14) 
excel VTM 
The New Gold 
Standard for 
Vascular & Benign 
Pigmented Lesions
AP0732 Rev A (07/14) 
Overview 
I. Introduction 
II. excel V™ Advanced Dual Wavelength Laser 
III. excel V 532 nm 
IV. exc...
AP0732 Rev A (07/14) 
excel V At a Glance 
CUTERA’s excel V is the most advanced 
precision laser to treat ALL vascular an...
Versatility and efficacy for all vascular lesions 
and benign pigmented lesions 
AP0732 Rev A (07/14)
AP0732 Rev A (07/14) 
Indications 
• Telangiectasia 
• Leg Veins 
• Spider Angiomas 
• Cherry Angiomas 
• Neovascularizati...
Real Time Calibration 
• System continually monitors laser 
output to ensure each laser pulse is 
exactly the same – no wa...
AP0732 Rev A (07/14) 
Intelligent Delivery 
Excellent Visibility 
• Unique cut-out design 
• Large diameter sapphire windo...
AP0732 Rev A (07/14) 
Ease of Use 
Great visibility allows 
physician to watch the 
lesion response and 
adjust parameters...
Large individual vessels 
Larger vascular volume 
AP0732 Rev A (07/14) 
Key parameters for successful treatments 
1. Wavel...
AP0732 Rev A (07/14) 
excel VTM 
532 nm KTP
AP0732 Rev A (07/14) 
Absorption Spectrum
AP0732 Rev A (07/14) 
532 nm KTP
AP0732 Rev A (07/14) 
532 nm KTP Specifications 
• Fluence: 1.8 - 42 J/cm2 
• Spot Size: 2 – 12 mm 
• Pulse Duration: 1.5 ...
AP0732 Rev A (07/14) 
Pulse Width: 
Getting the Ideal 1 – 10 ms Pulse 
• V-Beam pulses are too short 
• Gemini pulses are ...
AP0732 Rev A (07/14) 
532 nm KTP : Telangiectasia 
Treatment Parameters 
532 nm : 4 mm, 10 J/cm2, 15 ms 
Photos Courtesy o...
AP0732 Rev A (07/14) 
532 nm KTP : Telangiectasia 
Before Post One Tx 
Treatment Parameters 
532 nm : 4 mm, 19 J/cm2, 15 m...
AP0732 Rev A (07/14) 
532 nm KTP : Rosacea 
Treatment Parameters 
532 nm : 7 J/cm2, 10 mm, 10 ms, 10°C 
Photos Courtesy of...
AP0732 Rev A (07/14) 
532 nm KTP : Rosacea 
Before Post 4 Txs 
Treatment Parameters 
532 nm : 10 mm, 7 J/cm2, 12 ms 
Photo...
AP0732 Rev A (07/14) 
532 nm KTP : Rosacea 
Before Post 3 Txs 
Treatment Parameters 
532 nm : 10 mm, 7.4 J/cm2, 10 ms, 5˚C...
AP0732 Rev A (07/14) 
532 nm KTP : Rosacea 
Before Post 2 Txs 
Treatment Parameters 
532 nm : 10 mm, 7.4 J/cm2, 10 ms, 5˚C...
532 nm KTP : Telangiectasia, Rosacea and 
Photo-damage 
AP0732 Rev A (07/14) 
Treatment Parameters 
Telangiectasia : 532 n...
AP0732 Rev A (07/14) 
532 nm KTP : Spider Angioma 
Before Post One Tx 
Treatment Parameters 
1064 nm : 3 mm, 10 ms, 120 J/...
AP0732 Rev A (07/14) 
532 nm KTP : Spider Angioma 
Before Post One Tx 
Treatment Parameters 
532 nm : 5 mm, 13 J/cm2, 7 ms...
AP0732 Rev A (07/14) 
532 nm KTP : Spider Angioma 
Before Post One Tx 
Treatment Parameters 
532 nm : 6 mm, 6 J/cm2, 15 ms...
AP0732 Rev A (07/14) 
532 nm KTP : Rosacea 
Before Post One Tx 
Photos Courtesy of Jeffrey Hsu, MD,/ Ashish Bhatia, M.D.
AP0732 Rev A (07/14) 
532 nm KTP : Poikiloderma 
Before Post One Tx 
Treatment Parameters 
532 nm : 10 mm, 15 ms, 6.6 J/cm...
AP0732 Rev A (07/14) 
532 nm KTP : Poikiloderma 
Before Post 3 Txs 
Treatment Parameters 
532 nm : 10 mm, 7.4 J/cm2, 10 ms...
AP0732 Rev A (07/14) 
532 nm KTP : Poikiloderma 
Before Post 3 Txs 
Treatment Parameters 
532 nm : 6.6 J/cm2, 10 mm, 12 ms...
AP0732 Rev A (07/14) 
532 nm KTP : Resistant Port Wine Stain 
Before Post One Tx 
Treatment Parameters 
532 nm : 7 J/cm2, ...
AP0732 Rev A (07/14) 
532 nm KTP : Light Lentigines 
Before Post One Tx 
Treatment Parameters 
532 nm : 12-16 J/cm2, 4-10 ...
AP0732 Rev A (07/14) 
532 nm KTP : Solar Lentigo 
Before 8 Days Post One Tx 
Treatment Parameters 
532 nm : 6mm, 10J cm2, ...
532 nm KTP : Vascular & Benign Pigment 
AP0732 Rev A (07/14) 
Before Post 2 Txs 
Treatment Parameters 
532 nm : 7-7.2 J/cm...
532 nm KTP : Vascular & Benign Pigment 
AP0732 Rev A (07/14) 
Before Post 2 Txs 
Treatment Parameters 
532 nm : 7-7.2 J/cm...
AP0732 Rev A (07/14) 
532 nm KTP : Port Wine Stain 
Before Post 9 Txs 
Treatment Parameters 
1064 nm : 70J/cm2, 25ms, 7mm ...
3 
AP0732 Rev A (07/14) 
43 yr. old male with injury playing soccer to right popliteal fossa 
on 9.22.2013 
Kevin Smith MD...
AP0732 Rev A (07/14) 
532 nm KTP : Bruise : Treatment One 
43 yr. old male with injury playing soccer to right popliteal f...
Before Session 2 – 9.28.13 1 HOUR after Session 2 (KTP only) 
Photos courtesy of Kevin Smith, MD 
AP0732 Rev A (07/14) 
53...
AP0732 Rev A (07/14) 
532 nm KTP : Bruising 
Before 2 Days Post One Tx 
Treatment Parameters 
532 nm : 10 mm, 15 ms, 5 J/c...
AP0732 Rev A (07/14) 
532 nm KTP : Bruising 
Before 2 Days Post One Tx 
TreatmentIm Pmaerdaiamteelyt Aefrtser 
532 nm : 5 ...
AP0732 Rev A (07/14) 
excel VTM 
1064 nm truPulseTM
AP0732 Rev A (07/14) 
Wavelength Absorption Spectrum
AP0732 Rev A (07/14) 
1064 nm Nd:YAG
AP0732 Rev A (07/14) 
1064 nm truPulse Specifications 
• Fluence: 2- 300 J/cm2 
• Spot Size: 2 – 12 mm 
• Pulse Duration: ...
AP0732 Rev A (07/14) 
1064 nm truPulse 
• Neodymium yttrium aluminum garnet (Nd:YAG) 
• Greater depth of penetration than ...
AP0732 Rev A (07/14) 
• Neodymium yttrium aluminum garnet (Nd:YAG) 
• Greater depth of penetration than other lasers (> 5 ...
AP0732 Rev A (07/14) 
1064 nm truPulse : Venous Lake 
Before Post One Tx 
Treatment Parameters 
1064 nm : 7 mm, 30 ms, 90 ...
AP0732 Rev A (07/14) 
1064 nm truPulse : Venous Lake 
Before Post 2 Txs 
Treatment Parameters 
1064 nm : 3 mm, 10 ms, 140 ...
AP0732 Rev A (07/14) 
1064 nm truPulse : Chest Veins 
Before Post One Tx 
Treatment Parameters 
1064 nm : 125 J/cm2, 5 mm,...
AP0732 Rev A (07/14) 
1064 nm truPulse : Chest Veins 
Before Post 2 Txs 
Treatment Parameters 
1064 nm : 135(115) J/cm2, 5...
AP0732 Rev A (07/14) 
1064 nm truPulse : Periorbital Vessel 
Before Post 2 Txs 
Treatment Parameters 
1064 nm : Tx 1: 110 ...
AP0732 Rev A (07/14) 
1064 nm truPulse : Periorbital Vessel 
Before Post 2 Txs 
Treatment Parameters 
1064 nm : 100 J/cm2,...
AP0732 Rev A (07/14) 
1064 nm truPulse : Forehead Veins 
Before Post One Tx 
Treatment Parameters 
1064 nm : 110 J/cm2, 5 ...
AP0732 Rev A (07/14) 
1064 nm truPulse : Periorbital Vessel 
Before Post One Tx 
Treatment Parameters 
1064 nm : 110 J/cm2...
AP0732 Rev A (07/14) 
1064 nm truPulse : Telangiectasia 
Before Post 2 Txs 
Treatment Parameters 
1064 nm : 130 J/cm2, 5 m...
1064 nm truPulse : Reticular Vein – Matting (Legs) 
AP0732 Rev A (07/14) 
Before Post One Tx 
Treatment Parameters 
1064 n...
AP0732 Rev A (07/14) 
1064 nm truPulse : Spider Veins 
Before Post One Tx 
Treatment Parameters 
1064 nm : 100-180 J/cm2, ...
AP0732 Rev A (07/14) 
1064 nm truPulse : Leg Veins 
Before Post 3 Txs 
Treatment Parameters 
1064 nm : 130 J/cm2, 6 mm, 10...
AP0732 Rev A (07/14) 
1064 nm truPulse : Spider Veins 
Before Post One Tx 
Treatment Parameters 
1064 nm : 3 mm, 150 J/cm2...
AP0732 Rev A (07/14) 
1064 nm truPulse : Leg Veins 
Before Post 2 Txs 
Treatment Parameters 
1064 nm : 160 J/cm2 4mm, 25 m...
AP0732 Rev A (07/14) 
1064 nm truPulse : Leg Veins 
Before Post 2 Txs 
Treatment Parameters 
1064 nm : 160 J/cm2, 4mm, 25 ...
AP0732 Rev A (07/14) 
Warts Clinical Evidence 
Summary of results: Long-Pulsed Nd:YAG Laser 
Treatment of Warts[1] 
• Over...
Before and After Clinical Documentation 
Baseline 1-month post-1 Tx 
Photos Courtesy of David Weiss, DPM
AP0732 Rev A (07/14) 
Genesis V Specifications 
• Wavelength: 1064 nm 
• Fluence: 4-7 J/cm2 
• Spot Size: 8 mm 
• Pulse Du...
Genesis V : Proprietary Design, Micro-Second 
Pulse Technology 
• Two aiming beams ensure correct working distance 
• Temp...
AP0732 Rev A (07/14) 
1064 nm Genesis V : Laser Genesis 
Thermal imaging reveals even heating to target
AP0732 Rev A (07/14)
AP0732 Rev A (07/14) 
1064 nm Genesis V : Laser Genesis : 
Diffuse Redness 
Before Post 6 Txs 
Photos Courtesy of David Va...
AP0732 Rev A (07/14) 
1064 nm Genesis V : Laser Genesis : 
Diffuse Redness 
Before 2 Months Post 6 Txs 
Photos Courtesy of...
AP0732 Rev A (07/14) 
1064 nm Genesis V : Laser Genesis : 
Acne Scars 
Before 2.5 Months Post 4 Txs 
Photos Courtesy of Da...
AP0732 Rev A (07/14) 
1064 nm Genesis V : Laser Genesis : 
Acne Scars 
Before 2.5 Months Post 4 Txs 
Photos Courtesy of Da...
AP0732 Rev A (07/14) 
1064 nm Genesis V : Laser Genesis : 
Acne Scars 
Before Post 6 Txs 
Photos Courtesy of Tomei & Ashra...
AP0732 Rev A (07/14) 
1064 nm Genesis V : Laser Genesis 
Before 4 Months Post 6 Txs 
Photos Courtesy of Tomei & Ashraf Bad...
AP0732 Rev A (07/14) 
1064 nm : truPulse + Genesis V 
Before Post 2 Txs 
Treatment Parameters 
532 nm: 7 J/cm2 , 10 mm, 10...
AP0732 Rev A (07/14) 
1064 nm : truPulse + Genesis V 
Before Post 2Txs 
Treatment Parameters 
532 nm: 7 J/cm2 , 10 mm, 10 ...
AP0732 Rev A (07/14) 
Before and After Clinical Documentation 
Before Post treatment Baseline 1-month post-3 Tx 
Photos Co...
AP0732 Rev A (07/14) 
Highlights In Review 
• Large spot, short pulse widths at therapeutic fluences 
• Purpuric and Non-p...
AP0732 Rev A (07/14) 
• Industry leading research & development 
 Temperature sensor 
 Aiming beam 
 Pulse Counter 
 R...
AP0732 Rev A (07/14) 
Temperature Monitoring 
LED Color Temp 
Range 
Green 26-30 o C 
Green 31-34 o C 
Green 35-38 o C 
Ye...
AP0732 Rev A (07/14) 
5mm Clinical Evidence 
• Summary of results 16 weeks post final 
treatment: 
 (81%) showed either “...
Before and After Clinical Documentation 
Baseline 6-months-post-final-Tx 
Infected Area=23.6% Infected Area = 9.4% 
Photos...
Before and After Clinical Documentation 
AP0732 Rev A (07/14) 
Baseline 6-months-post-final-Tx 
Infected Area=23.6% Infect...
Before and After Clinical Documentation 
Baseline 3-months 
post-final Tx 
6-months 
post-final Tx 
Photos Courtesy of Mic...
Thank You. 
AP0732 Rev A (07/14) 
Questions?
Excel V
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Excel V

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Cutera Excel V Nd:YAG + KTP Laser

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Excel V

  1. 1. AP0732 Rev A (07/14) excel VTM The New Gold Standard for Vascular & Benign Pigmented Lesions
  2. 2. AP0732 Rev A (07/14) Overview I. Introduction II. excel V™ Advanced Dual Wavelength Laser III. excel V 532 nm IV. excel V 1064 nm V. Genesis V™ 1064 nm Micro-Pulsed Laser
  3. 3. AP0732 Rev A (07/14) excel V At a Glance CUTERA’s excel V is the most advanced precision laser to treat ALL vascular and many benign pigmented conditions ROI Extensive Tx capabilities, no consumables Versatility Effectively treats all vascular and most BPLs, All skin types Technology High-Powered Dual wavelength (532 nm/1064 nm) Efficiency Large spot, short pulse width at therapeutic fluences
  4. 4. Versatility and efficacy for all vascular lesions and benign pigmented lesions AP0732 Rev A (07/14)
  5. 5. AP0732 Rev A (07/14) Indications • Telangiectasia • Leg Veins • Spider Angiomas • Cherry Angiomas • Neovascularization • Venous Lakes Vascular Lesions • Port Wine Stains • Rosacea/ Matting • Diffused Redness Benign Pigmented Lesions • Lentigines • DPN’s • Poikiloderma of Civatte • Freckles • Café-au-lait Stains • Melasma Cutaneous Lesions • Verruca • Skin Tags • Keratoses Other • Red Scars
  6. 6. Real Time Calibration • System continually monitors laser output to ensure each laser pulse is exactly the same – no waiting for The First High-energy calibration. Flashlamp Pumped 532nm and 1064nm Intuitive User Interface • Recommends settings for novice or allows direct selection for advanced users No Disposables/Consumables • Sapphire cooling • Solid-state design • Plugs into 110v or 220v AP0732 Rev A (07/14) Advanced Design Compact Design • Small footprint • 30 seconds start up • Runs quiet and cool Solid State Laser Kilowatt Peak Power Levels Capable of purpura Up to 10 Hz
  7. 7. AP0732 Rev A (07/14) Intelligent Delivery Excellent Visibility • Unique cut-out design • Large diameter sapphire window • Visibility throughout treatment Adjustable Spot Size • On-the-fly adjustments, system stays in Ready Mode, saves time • 2mm to 12mm • Real-time calibration Parallel Cooling • Variable temperature sapphire window • Superior cooling before, during, and after each pulse • Selectable 5°C to 20 °C
  8. 8. AP0732 Rev A (07/14) Ease of Use Great visibility allows physician to watch the lesion response and adjust parameters accordingly
  9. 9. Large individual vessels Larger vascular volume AP0732 Rev A (07/14) Key parameters for successful treatments 1. Wavelength 532 Pigment/Vascular 1064 Deeper/Larger vessels 2. Spot size 3. Pulse duration 4. Fluence 5. Cooling Superficial vessels Small individual vessels Deep vessels Smaller vessels Smaller vascular volume Larger vessels Low pressure vessels Dark purple vessels Larger vessels High pressure vessels Pink vessels Smaller vessels Pigment Vessels
  10. 10. AP0732 Rev A (07/14) excel VTM 532 nm KTP
  11. 11. AP0732 Rev A (07/14) Absorption Spectrum
  12. 12. AP0732 Rev A (07/14) 532 nm KTP
  13. 13. AP0732 Rev A (07/14) 532 nm KTP Specifications • Fluence: 1.8 - 42 J/cm2 • Spot Size: 2 – 12 mm • Pulse Duration: 1.5 – 40 ms • Repetition Rate: 0 to 4 Hz
  14. 14. AP0732 Rev A (07/14) Pulse Width: Getting the Ideal 1 – 10 ms Pulse • V-Beam pulses are too short • Gemini pulses are too long • Excel V pulses need to be just right Gemini 532nm 7.5 J/cm2 20ms
  15. 15. AP0732 Rev A (07/14) 532 nm KTP : Telangiectasia Treatment Parameters 532 nm : 4 mm, 10 J/cm2, 15 ms Photos Courtesy of Neil Sadick, M.D. Before Post One Tx
  16. 16. AP0732 Rev A (07/14) 532 nm KTP : Telangiectasia Before Post One Tx Treatment Parameters 532 nm : 4 mm, 19 J/cm2, 15 ms Photos Courtesy of Neil Sadick, M.D.
  17. 17. AP0732 Rev A (07/14) 532 nm KTP : Rosacea Treatment Parameters 532 nm : 7 J/cm2, 10 mm, 10 ms, 10°C Photos Courtesy of Jeremy B. Green, M.D. Post 3 Txs
  18. 18. AP0732 Rev A (07/14) 532 nm KTP : Rosacea Before Post 4 Txs Treatment Parameters 532 nm : 10 mm, 7 J/cm2, 12 ms Photos Courtesy of Neil Sadick, M.D.
  19. 19. AP0732 Rev A (07/14) 532 nm KTP : Rosacea Before Post 3 Txs Treatment Parameters 532 nm : 10 mm, 7.4 J/cm2, 10 ms, 5˚C Photos Courtesy of Mary Lupo, M.D.
  20. 20. AP0732 Rev A (07/14) 532 nm KTP : Rosacea Before Post 2 Txs Treatment Parameters 532 nm : 10 mm, 7.4 J/cm2, 10 ms, 5˚C Photos Courtesy of Jeffrey Hsu, MD – Ashish Bhatia, M.D.
  21. 21. 532 nm KTP : Telangiectasia, Rosacea and Photo-damage AP0732 Rev A (07/14) Treatment Parameters Telangiectasia : 532 nm, 8.6 J/cm2, 5 mm, 10 ms, 10°C Rosacea : 532 nm, 8 J/cm2, 10 mm, 9 ms, 10°C Photos Courtesy of Macrene Alexiades, M.D., Ph.D Post 2 Txs Before
  22. 22. AP0732 Rev A (07/14) 532 nm KTP : Spider Angioma Before Post One Tx Treatment Parameters 1064 nm : 3 mm, 10 ms, 120 J/cm2, 5°C 532 nm : 6 mm, 15 ms, 8 J/cm2, 5°C Photos Courtesy of Cesar Arroyo, M.D.
  23. 23. AP0732 Rev A (07/14) 532 nm KTP : Spider Angioma Before Post One Tx Treatment Parameters 532 nm : 5 mm, 13 J/cm2, 7 ms, 5˚C, 3 Pulses Photos Courtesy of Mary Lupo, M.D.
  24. 24. AP0732 Rev A (07/14) 532 nm KTP : Spider Angioma Before Post One Tx Treatment Parameters 532 nm : 6 mm, 6 J/cm2, 15 ms 10°C Photos Courtesy of Cesar Arroyo, M.D.
  25. 25. AP0732 Rev A (07/14) 532 nm KTP : Rosacea Before Post One Tx Photos Courtesy of Jeffrey Hsu, MD,/ Ashish Bhatia, M.D.
  26. 26. AP0732 Rev A (07/14) 532 nm KTP : Poikiloderma Before Post One Tx Treatment Parameters 532 nm : 10 mm, 15 ms, 6.6 J/cm2, 5°C Photos Courtesy of Joely Kaufman, M.D.
  27. 27. AP0732 Rev A (07/14) 532 nm KTP : Poikiloderma Before Post 3 Txs Treatment Parameters 532 nm : 10 mm, 7.4 J/cm2, 10 ms, 5˚C Photos Courtesy of Mary Lupo, M.D.
  28. 28. AP0732 Rev A (07/14) 532 nm KTP : Poikiloderma Before Post 3 Txs Treatment Parameters 532 nm : 6.6 J/cm2, 10 mm, 12 ms, 10°C Photos Courtesy of Jeremy B. Green, M.D.
  29. 29. AP0732 Rev A (07/14) 532 nm KTP : Resistant Port Wine Stain Before Post One Tx Treatment Parameters 532 nm : 7 J/cm2, 7 mm, 6 ms, 5°C Photos Courtesy of Macrene Alexiades, M.D. Immediately After Tx
  30. 30. AP0732 Rev A (07/14) 532 nm KTP : Light Lentigines Before Post One Tx Treatment Parameters 532 nm : 12-16 J/cm2, 4-10 ms, 3 mm, 15°C Photos Courtesy of Grant Stevens, M.D.
  31. 31. AP0732 Rev A (07/14) 532 nm KTP : Solar Lentigo Before 8 Days Post One Tx Treatment Parameters 532 nm : 6mm, 10J cm2, 7ms, 15°C Photos Courtesy of Adam Gropper, M.D. 4 Days Post One Tx
  32. 32. 532 nm KTP : Vascular & Benign Pigment AP0732 Rev A (07/14) Before Post 2 Txs Treatment Parameters 532 nm : 7-7.2 J/cm2, 10 mm, 12 ms, 15°C - 1 pass w/ 20% OL Photos Courtesy of David Vasily, M.D.
  33. 33. 532 nm KTP : Vascular & Benign Pigment AP0732 Rev A (07/14) Before Post 2 Txs Treatment Parameters 532 nm : 7-7.2 J/cm2, 10 mm, 12 ms, 15°C - 1 pass w 20% OL Photos Courtesy of David Vasily, M.D.
  34. 34. AP0732 Rev A (07/14) 532 nm KTP : Port Wine Stain Before Post 9 Txs Treatment Parameters 1064 nm : 70J/cm2, 25ms, 7mm 532 nm : 7J/cm2, 8ms, 10mm Photos Courtesy of CUTERA Clinic
  35. 35. 3 AP0732 Rev A (07/14) 43 yr. old male with injury playing soccer to right popliteal fossa on 9.22.2013 Kevin Smith MD FRCPC – Niagara Fall, Canada Objective: To evaluate the efficacy of 532 nm KTP (excel V) for the treatment of bruise Study Design: 1 male adult with bruise Patient received 2 treatments • Treatment Session 1 – 9.27.2013  Quadrant 1 : Nd:YAG 1064 nm – 9 mm, 60 J/cm2, 40 ms  Quadrant 2 : KTP 532 nm – 9 mm, 14 J/cm2, 20 ms  Quadrant 3 : IPL LimeLight - 1x3 cm spot, 20 J/cm2, Program A  Quadrant 4: Control area was not treated • Treatment Session 2 – 9.28.2013  All 4 quadrants were treated with KTP 532 nm – 9 mm, 14 J/cm2, 20 ms 1 2 4 5 day old bruise Photos Courtesy of Kevin Smith, M.D. 532 nm KTP : Clinical Validation
  36. 36. AP0732 Rev A (07/14) 532 nm KTP : Bruise : Treatment One 43 yr. old male with injury playing soccer to right popliteal fossa on 9.22.2013 Kevin Smith MD FRCPC – Niagara Fall, Canada Before 9.27.13 1 Day after session 1 - 9.28.13 Nd:YAG IPL KTP Contro Treatment Session 1 – 9.27.2013 l  Quadrant 1 : Nd:YAG 1064 nm – 9 mm, 60 J/cm2, 40 ms  Quadrant 2 : KTP 532 nm – 9 mm, 14 J/cm2, 20 ms  Quadrant 3 : IPL LimeLight - 1x3 cm spot, 20 J/cm2, Program A  Quadrant 4: Control area was not treated Nd:YAG IPL KTP Control Photos courtesy of Kevin Smith, MD
  37. 37. Before Session 2 – 9.28.13 1 HOUR after Session 2 (KTP only) Photos courtesy of Kevin Smith, MD AP0732 Rev A (07/14) 532 nm KTP : Bruise : Treatment Two 43 yr. old male with injury playing soccer to right popliteal fossa on 9.22.2013 Kevin Smith MD FRCPC – Niagara Fall, Canada Treatment Session 2 – 9.28.2013  All Quadrants (entire bruise) treated using KTP: KTP 532 nm – 9 mm, 14 J/cm2, 20 ms
  38. 38. AP0732 Rev A (07/14) 532 nm KTP : Bruising Before 2 Days Post One Tx Treatment Parameters 532 nm : 10 mm, 15 ms, 5 J/cm2, 10° C Photos Courtesy of David Holcomb, M.D.
  39. 39. AP0732 Rev A (07/14) 532 nm KTP : Bruising Before 2 Days Post One Tx TreatmentIm Pmaerdaiamteelyt Aefrtser 532 nm : 5 mm, 8-12 ms, 7 J/cm2, 10°C Photos Courtesy of Mary Lupo, M.D.
  40. 40. AP0732 Rev A (07/14) excel VTM 1064 nm truPulseTM
  41. 41. AP0732 Rev A (07/14) Wavelength Absorption Spectrum
  42. 42. AP0732 Rev A (07/14) 1064 nm Nd:YAG
  43. 43. AP0732 Rev A (07/14) 1064 nm truPulse Specifications • Fluence: 2- 300 J/cm2 • Spot Size: 2 – 12 mm • Pulse Duration: 5 – 60 ms • Repetition Rate: 0 to 2 Hz
  44. 44. AP0732 Rev A (07/14) 1064 nm truPulse • Neodymium yttrium aluminum garnet (Nd:YAG) • Greater depth of penetration than other lasers (> 5 mm when used with epidermal cooling) • Endpoint: disappearance (vasospasm) or bluish color change (thermocoagulation/thrombosis) • Low melanin absorption (ideal for darker skin types)
  45. 45. AP0732 Rev A (07/14) • Neodymium yttrium aluminum garnet (Nd:YAG) • Greater depth of penetration than other lasers (> 5 mm when used with epidermal cooling) • Endpoint: disappearance (vasospasm) or bluish color change (thermocoagulation/thrombosis) • Low melanin absorption (ideal for darker skin types)
  46. 46. AP0732 Rev A (07/14) 1064 nm truPulse : Venous Lake Before Post One Tx Treatment Parameters 1064 nm : 7 mm, 30 ms, 90 J/cm2 Photos Courtesy of Hideko Yambe, M.D.
  47. 47. AP0732 Rev A (07/14) 1064 nm truPulse : Venous Lake Before Post 2 Txs Treatment Parameters 1064 nm : 3 mm, 10 ms, 140 J/cm2 Photos Courtesy of E. Victor Ross, M.D.
  48. 48. AP0732 Rev A (07/14) 1064 nm truPulse : Chest Veins Before Post One Tx Treatment Parameters 1064 nm : 125 J/cm2, 5 mm, 30 ms, 5°C Photos Courtesy of Jeremy B. Green, M.D.
  49. 49. AP0732 Rev A (07/14) 1064 nm truPulse : Chest Veins Before Post 2 Txs Treatment Parameters 1064 nm : 135(115) J/cm2, 5 mm, 25(30) ms, 5°C Photos Courtesy of Jeremy B. Green, M.D.
  50. 50. AP0732 Rev A (07/14) 1064 nm truPulse : Periorbital Vessel Before Post 2 Txs Treatment Parameters 1064 nm : Tx 1: 110 J/cm2, 4 mm, 35 ms, 5˚C – 17 Pulses 1064 nm : Tx 2: 110 J/cm2, 5 mm, 35 ms, 5˚C – 12 Pulses Photos Courtesy of Mary Lupo, M.D.
  51. 51. AP0732 Rev A (07/14) 1064 nm truPulse : Periorbital Vessel Before Post 2 Txs Treatment Parameters 1064 nm : 100 J/cm2, 6 mm, 45 ms, 5°C Photos Courtesy of Mary Lupo, M.D.
  52. 52. AP0732 Rev A (07/14) 1064 nm truPulse : Forehead Veins Before Post One Tx Treatment Parameters 1064 nm : 110 J/cm2, 5 mm, 45 ms, 5°C Photos Courtesy of Mary Lupo, M.D.
  53. 53. AP0732 Rev A (07/14) 1064 nm truPulse : Periorbital Vessel Before Post One Tx Treatment Parameters 1064 nm : 110 J/cm2, 5 mm, 30 ms, 5°C Photos Courtesy of Jeremy B. Green, M.D.
  54. 54. AP0732 Rev A (07/14) 1064 nm truPulse : Telangiectasia Before Post 2 Txs Treatment Parameters 1064 nm : 130 J/cm2, 5 mm, 30 ms, 5°C Photos Courtesy of Ceasar Arroyo, M.D.
  55. 55. 1064 nm truPulse : Reticular Vein – Matting (Legs) AP0732 Rev A (07/14) Before Post One Tx Treatment Parameters 1064 nm : 110 J/cm2, 5 mm, 40 ms, 5°C 532 nm : 10 J/cm2, 5 mm, 10 ms, 5°C Photos Courtesy of Jeffrey Hsu, MD and Ashish Bhatia, M.D.
  56. 56. AP0732 Rev A (07/14) 1064 nm truPulse : Spider Veins Before Post One Tx Treatment Parameters 1064 nm : 100-180 J/cm2, 5mm, 10-40 ms, 5°C Photos Courtesy of Jeffrey Hsu, MD and Ashish Bhatia, M.D.
  57. 57. AP0732 Rev A (07/14) 1064 nm truPulse : Leg Veins Before Post 3 Txs Treatment Parameters 1064 nm : 130 J/cm2, 6 mm, 10 ms, 5°C Photos Courtesy of Cesar Arroyo, M.D.
  58. 58. AP0732 Rev A (07/14) 1064 nm truPulse : Spider Veins Before Post One Tx Treatment Parameters 1064 nm : 3 mm, 150 J/cm2, 15 ms Photos Courtesy of Neil Sadick, M.D.
  59. 59. AP0732 Rev A (07/14) 1064 nm truPulse : Leg Veins Before Post 2 Txs Treatment Parameters 1064 nm : 160 J/cm2 4mm, 25 ms, 5°C 1064 nm : 165 J/cm2, 6 mm, 40 ms, 5°C Photos Courtesy of David Vasily, M.D.
  60. 60. AP0732 Rev A (07/14) 1064 nm truPulse : Leg Veins Before Post 2 Txs Treatment Parameters 1064 nm : 160 J/cm2, 4mm, 25 ms, 5°C 1064 nm : 165 J/cm2, 6 mm, 40 ms, 5°C Photos Courtesy of David Vasily, M.D.
  61. 61. AP0732 Rev A (07/14) Warts Clinical Evidence Summary of results: Long-Pulsed Nd:YAG Laser Treatment of Warts[1] • Overall clearance rate was 96%  369 patients with recalcitrant or untreated warts  21 patients were lost during follow-up • 336 of the 348 treated warts were eradicated “Long-pulsed Nd:YAG laser is safe and effective for the removal or reduction of warts and is less dependent on patient compliance than are other treatment options” [1] [1] T, Y Han, et al, “Long-Pulsed Nd:YAG Laser Treatment of Warts: Report on a Series of 369 Cases” J Korean Med Sci 2009; 24: 889-93
  62. 62. Before and After Clinical Documentation Baseline 1-month post-1 Tx Photos Courtesy of David Weiss, DPM
  63. 63. AP0732 Rev A (07/14) Genesis V Specifications • Wavelength: 1064 nm • Fluence: 4-7 J/cm2 • Spot Size: 8 mm • Pulse Duration: 0.3 ms • Repetition Rate: 0 to 10 Hz • Epidermal Cooling: none • Patented 1064 nm Laser Genesis procedure targets the micro-vascularity with microsecond high peak power pulse • Safe for all skin types
  64. 64. Genesis V : Proprietary Design, Micro-Second Pulse Technology • Two aiming beams ensure correct working distance • Temperature sensors for real time temperature AP0732 Rev A (07/14) feedback • Safe and effective treatment outcomes
  65. 65. AP0732 Rev A (07/14) 1064 nm Genesis V : Laser Genesis Thermal imaging reveals even heating to target
  66. 66. AP0732 Rev A (07/14)
  67. 67. AP0732 Rev A (07/14) 1064 nm Genesis V : Laser Genesis : Diffuse Redness Before Post 6 Txs Photos Courtesy of David Vasily, M.D.
  68. 68. AP0732 Rev A (07/14) 1064 nm Genesis V : Laser Genesis : Diffuse Redness Before 2 Months Post 6 Txs Photos Courtesy of David Vasily, M.D.
  69. 69. AP0732 Rev A (07/14) 1064 nm Genesis V : Laser Genesis : Acne Scars Before 2.5 Months Post 4 Txs Photos Courtesy of David Vasily, M.D.
  70. 70. AP0732 Rev A (07/14) 1064 nm Genesis V : Laser Genesis : Acne Scars Before 2.5 Months Post 4 Txs Photos Courtesy of David Vasily, M.D.
  71. 71. AP0732 Rev A (07/14) 1064 nm Genesis V : Laser Genesis : Acne Scars Before Post 6 Txs Photos Courtesy of Tomei & Ashraf Badawi, M.D.
  72. 72. AP0732 Rev A (07/14) 1064 nm Genesis V : Laser Genesis Before 4 Months Post 6 Txs Photos Courtesy of Tomei & Ashraf Badawi, M.D.
  73. 73. AP0732 Rev A (07/14) 1064 nm : truPulse + Genesis V Before Post 2 Txs Treatment Parameters 532 nm: 7 J/cm2 , 10 mm, 10 ms, 5°C Photos Courtesy of Mary Lupo, M.D.
  74. 74. AP0732 Rev A (07/14) 1064 nm : truPulse + Genesis V Before Post 2Txs Treatment Parameters 532 nm: 7 J/cm2 , 10 mm, 10 ms, 5°C 1064 nm (x2) Photos Courtesy of Mary Lupo, M.D.
  75. 75. AP0732 Rev A (07/14) Before and After Clinical Documentation Before Post treatment Baseline 1-month post-3 Tx Photos Courtesy of Jodi Schoenhaus, DPM
  76. 76. AP0732 Rev A (07/14) Highlights In Review • Large spot, short pulse widths at therapeutic fluences • Purpuric and Non-purpuric settings • Excellent visibility • Excellent, variable cooling • Able to treat red/brown dyschromia in one pass • Fast 2 Hz rep rate at 12 mm spot size • Quick start up, quick cool down • Real time calibration – saves time • Genesis V handpiece can be added for non-ablative, no downtime, skin revitalization • Treats all parts of the body • Indicated for all skin types
  77. 77. AP0732 Rev A (07/14) • Industry leading research & development  Temperature sensor  Aiming beam  Pulse Counter  Real time calibration
  78. 78. AP0732 Rev A (07/14) Temperature Monitoring LED Color Temp Range Green 26-30 o C Green 31-34 o C Green 35-38 o C Yellow 39-42 o C Yellow 43-46 o C Red 47-50 o C
  79. 79. AP0732 Rev A (07/14) 5mm Clinical Evidence • Summary of results 16 weeks post final treatment:  (81%) showed either “complete clearance” or “moderate to significant” clearance  (51%) showed “complete clearance” with 100% testing negative for fungi  (16%) that showed no improvement had a turbidity of 10 at baseline Kimura, Takeuchi, Kinoshita et al. Journal of Drugs in Dermatology
  80. 80. Before and After Clinical Documentation Baseline 6-months-post-final-Tx Infected Area=23.6% Infected Area = 9.4% Photos Courtesy of David Weiss, DPM
  81. 81. Before and After Clinical Documentation AP0732 Rev A (07/14) Baseline 6-months-post-final-Tx Infected Area=23.6% Infected Area = 9.4% Photos Courtesy of David Weiss, DPM
  82. 82. Before and After Clinical Documentation Baseline 3-months post-final Tx 6-months post-final Tx Photos Courtesy of Michael Uro, DPM
  83. 83. Thank You. AP0732 Rev A (07/14) Questions?

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