4. Geriatric MDD and BPAD are Common
– Major Depressive Disorder: 2.7 % of elders
(Community 1 yr prev.)
– Significant depressive symptoms: 8‐15 %
– Bipolar disorder: 0.1‐0.4 % of elders
• 6 % of geriatric outpatient visits
• 8‐10 % of geriatric inpatient admissions
• 3 % of nursing home residents
• 17 % of geriatric presentations to psychiatric ED
1. Hybels CF, Blazer DG. Epidemiology of late‐life mental disorders. Clin Geriatr Med. 2003
Nov;19(4):663‐96, Review. 2. Depp CA, et al. Bipolar Disord. 2004;6(5):343‐367
3. Depp CA, et al. Am J Geriatr Psychiatry. 2005;13(4):290‐298
4. Yassa R, et al. Psychiatr Clin North Am. 1988;11(1):117‐131.
13. Neuropsychological battery
Cognitive variable measured Instrument used
Intellectual functioning Wechsler Abbreviated Scale of Intelligence (WASI)
Visual confrontation naming Boston Naming Test (BNT)
General cognitive function Mini Mental Status Exam (MMSE)
Verbal fluency—phonemic
fluency
FAS
Verbal fluency—semantic
fluency
Category Fluency‐‐Animals
Processing speed Trails A, Trails B, Stroop Color and Word Task
Working memory Trails B
Executive function FAS, Trails B, Stroop Color and Word Task, Wisconsin
Card Sorting Task
Short‐term recall CERAD word list
14. Demographics
Characteristic Control MDD BPAD Significance
Age, mean (S.E.) 65.6 (1.3) 71.4 (1.4) 65.2 (1.2) p= 0.001
Female, N (%) 17 (28.3) 25 (41.7) 18 (30.0) p< 0.05
Years of education,
mean (S.E.)
16.4 (0.4) 15.2 (0.5) 16.1 (0.4) N.S.
Age of first episode,
mean (S.E.)
N/A 38.4 (2.9) 24.2 (2.6) p< 0.001
N = 129 subjects, control: 44; MDD: 37; BPAD: 48
17. 20
30
40
50
60
Control MDD BPAD
20
30
40
50
60
70
Control MDD BPAD
Wisconsin Card Sorting Test CERAD Word List Recall
Control MDD BPAD Control MDD BPAD
Wisconsin Card Sorting Test Wisconsin Card Sorting Test CERAD Word List Recall TestCERAD Word List Recall Test
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***
***
***
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*** p<0.001
Executive Function Short‐term recall