Extreme weather events are becoming more common due to climate change, which is costing billions. Resources are also becoming scarcer as demand rises relentlessly. Additionally, transparency means business impacts on people and the planet can no longer be ignored. To address these wakeup calls, businesses must pursue deep change and innovation to make their organizations more resilient through heretical questioning, science-based goals, and reconsidering business models and what products truly fit a prosperous world. Answering this call is crucial because the future depends on business leadership in developing solutions.