Acquired analog signals can be manipulated and processed by either the analog or digital portions of a system, for example, through filtering, multiplexing, and gain control. The analog portions of a system can typically provide reasonably simple processing at fairly low cost, power, and overhead. Digital processing can provide far greater analysis power and can alter the nature of the analysis without changing hardware. Sampling theory, however, must be taken into account. This session covers the signal chain basics from signal to sensor to amplifier to converter to digital processor and back out again.