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  1. 1. IntroductionDefinitionThese are the Drug produce relaxant of skeletal muscle byinhibitingthe transmission of nerve impulse at neuromuscular junctionHistoryCURARE:- it is the generic name for certain plant extractsused by South America tribals as arrowpoison for game Hunting. the animal get paralyzed even if not killed.natural source of curare- Strychnos toxifera,- Chondrodendron tomentosusUses• general anesthetics to provide muscle Relaxant for surgery•Painful muscle spasms•Spastic neurological condition
  2. 2. ClassificationsI.Neuromuscular BlockingAgentA. Nondepolarizing (Competitive) blockers)1.Long acting: d-Tubocurarine, Pancuronium, Doxacurium, Pipercu2. Intermediate acting: Vecuronium,Atracurium, Cisatracurium, RocuRapacuronium3. Short acting: MivacuriumB. Depolarizing blockers-Succinylcholine, DecamethoniumII.Directly acting agent-Dantrolene sodium-Quinine
  3. 3. d-TubocurarineSource: (CURARE)Chondrodendron tomentosus,Strychnos lethalisIt is dextro rotatory competitiveblockers.Mainly used as an Arrow poison inhuntinganimals
  4. 4. MOAIt binds to the Nicotinic receptors on the motorendplate N thus blocks the action of Ach bycompetitive blockadeIf the concn of Ach varies (increase) d-Tubocurarine bockade is reversed
  5. 5. Pharmacological ActionSkeletal muscleinitially paralyses smaller muscle (finger, toes eyes ear)latter bigger muscle (limbs, neck, trunk followed by intercostalmuscles)Diaphragm is affected at last N recovery is reversed.CNSdon’t cross BBB & PB i.e no effect on CNSAutonomic gangliapartially blockade both autonomic ganglia & adernal medullaresulting fall of B.PHistamine Releasedirectly act on mast cell & produce Histamin causes >bronchospasm>increase salivary
  6. 6. Pharmacokinetics:A not absorb from GIT but wellabsorbed through IMD doesnt pass BBB &PBM in liverE  urine
  7. 7. ADR