This session will describe how members of the US Large Hadron Collider (LHC) community have benchmarked the usage of Amazon Elastic Compute Cloud (Amazon EC2) resource to simulate events observed by experiments at the European Organization for Nuclear Research (CERN). Miron Livny from the University of Wisconsin-Madison who has been collaborating with the US-LHC community for more than a decade will detail the process for benchmarking high-throughput computing (HTC) applications running across multiple AWS regions using the open source HTCondor distributed computing software. The presentation will also outline the different ways that AWS and HTCondor can help meet the needs of compute intensive applications from other scientific disciplines.