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How to promote brain health at scale: Examples in the workplace, K12 education and consumer tech

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How to promote brain health at scale: Examples in the workplace, K12 education and consumer tech

Louis Gagnon, CEO of Total Brain
Dr. Gregory Rose, Director of the Center for Integrated Research in Cognitive and Neural Sciences at SIU Med
Ariel Garten, Founder and Chief Evangelism Officer of InteraXon
Chaired by: Alvaro Fernandez, CEO and Editor-in-Chief at SharpBrains

Slidedeck supporting presentation and discussion during the 2019 SharpBrains Virtual Summit: The Future of Brain Health (March 7-9th). Learn more at:
https://sharpbrains.com/summit-2019/

Published in: Leadership & Management
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How to promote brain health at scale: Examples in the workplace, K12 education and consumer tech

  1. 1. How to promote brain health at scale: Examples in the workplace, K12 education and consumer tech Chaired by: Alvaro Fernandez, CEO and Editor-in-Chief at SharpBrains Dr. Gregory Rose, Director of the Center for Integrated Research in Cognitive and Neural Sciences at SIU Med Ariel Garten, Founder and Chief Evangelism Officer of InteraXon Louis Gagnon, CEO of Total Brain
  2. 2. How to Promote Brain Health at Scale… …in the Workplace Louis Gagnon, CEO, Total Brain • 7 May 2019
  3. 3. INTRODUCTION Over the last 25 years, I founded or led teams that: 1. Helped avert ‘00,000 of AIDS transmissions in Africa/Asia 2. Helped 50 millions people find jobs in 52 countries 3. Helped 50K US SMBs convert from YP to digital marketing 4. Helped 15M people discover audiobooks in 7 countries In 2018, our team recapitalized and re-built an 18-year old company called MyBrainSolutions and we launched Total Brain in October 2018. We are the first and only company to approach mental health through brain capacities as opposed to through psychological symptoms. 5 THE crisis of the day = mental health… and I signed-up to help Cause–driven entrepreneur / business executive Louis Gagnon CEO Total Brain
  4. 4. Mental Health and Fitness Platform INTRODUCTION TO TOTAL BRAIN Founded in 2000 by leading neuroscientist, Dr. Evian Gordon, MD, PhD. Mental Health is a Continuum. On one end, illness impairs brain capacities. On the other, fitness improves capacities. Total Brain assesses and trains brain capacities, in illness, fitness and anywhere in between => removing stigma and ensuring continuity of care – a first! Leading consumer groups and Fortune 500 companies benefit from strategic insights, better outputs, more productivity and less healthcare cost 6 TOTAL BRAIN = UNPRECEDENTED RESULTS MENTAL HEALTH ≠ ILLNESS MENTAL HEALTH CRISIS = ATTENTION NEEDED 80% of US employees are at-risk of having a mental condition 20% have a condition - 50% undiagnosed and untreated * Costing employees quality of life at-home and at-work * Costing employers quality of outputs, productivity and $$$
  5. 5. Neuroscientific Definition of Mental Health Mental Health is powered by 12 interdependent Brain Capacities SELF- CONTROL Social Connectivity Resilience Conscious Bias COGNITIVE Memory Focus Planning FEELING Anxiety Control Stress Control Depression Control EMOTIONAL Emo. Awareness Unconscious Bias Default Emotion All Brain Capacities can be impaired by Mental Conditions (Depression, Anxiety, PTSD, ADHD, Addiction, Sleep Apnea, Social Anxiety, etc.) Our Emotions greatly influence all other Brain Capacities
  6. 6. The Problem of Continuity of Care GOOD HEALTH FULL-CAPACITY – no risk, at-peak – AT-RISK UNDER-CAPACITY – subclinical condition – LOW HEALTH INCAPACITY – clinical condition– 8 Mental health is continuously changing By focusing on illness and ignoring fitness, we miss what’s in-between: the Risk AS A RESULT, WE INTERVENE TOO LATE, INCREASE COSTS AND CREATE STIGMA Sources: 1. NIMH https://www.nimh.nih.gov/health/statistics/mental-illness.shtml 2. NCBI, 2007, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852925/ 3. American Heart Association CEO Roundtable: Mental Health – A Workforce Crisis: https://goo.gl/torfyd Five times per second, life events trigger non-conscious Emotions that impact the Capacities that define our Mental Health. That’s why Mental Health is a Continuum, and not a State:
  7. 7. The Problem of Stigmatization 9 Misery is often normalized by our education (tough it up butter cup!) We do not feel the need to screen and if we do, the illness context is extremely stigmatizing AS A RESULT, 50% OF ALL CONDITIONS ARE UNDIAGNOSED AND UNTREATED2 Sources: 1. NIMH https://www.nimh.nih.gov/health/statistics/mental-illness.shtml 2. NCBI, 2007, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1852925/ 3. American Heart Association CEO Roundtable: Mental Health – A Workforce Crisis: https://goo.gl/torfyd 19% of the US population reports “excellent health”3 18% of US population has a clinical condition1 76% of US employees declare having an issue3 GOOD HEALTH FULL-CAPACITY – no risk, at-peak – AT-RISK UNDER-CAPACITY – subclinical condition – LOW HEALTH INCAPACITY – clinical condition– Five times per second, life events trigger non-conscious Emotions that impact the Capacities that define our Mental Health. That’s why Mental Health is a Continuum, and not a State:
  8. 8. Devastating Health and Productivity Costs 2010: $2.5 T1 2030: $6.1 T1 $17,241 per employee peryear² 10 GLOBAL YOUR SCALE COMPANY Sources: 1. World Economic Forum: https://goo.gl/zZQ8eV 2. American Heart Association CEO Roundtable: Mental Health – A Workforce Crisis: https://goo.gl/torfyd
  9. 9. Prevalence of Mental Conditions in Employed Populations 11Sources: 1. Internal book of business data of employees who took the Total Brain assessment screened at risk for at least 1 mental condition1 screened at risk for ADHD1 61% 33% screened at risk for PTSD1 14% screened at risk for Anxiety1 14% screened at risk for Social Anxiety1 14% screened at risk for Depression1 11% screened at risk for Sleep Apnea1 5%
  10. 10. The Total Brain Solution MEASURE TOTAL BRAIN (MONTHLY) BECOME AWARE 12 Brain Capacities 7 Mental Conditions 20 minutes Strengths and Weaknesses Risk Explanations Digital Brain Exercises Breathing and Meditation Science and Wisdom Symptom Validation by Users Call to EAP Initiated by Users OPTIONAL EMPLOYER FEATURE UNDERSTAND ONE’S MENTAL HEALTH RISK (CONDITIONS) AND TAKE ACTION ENGAGE WITH CUSTOM MENTAL FITNESS PROGRAM 12
  11. 11. Solving for Continuity of Care and Destigmatization 13 BRAIN DATA SUPPORTS DIAGNOSTIC, TREATMENT EFFECTIVENESS AND RECOVERY TRACKING CUSTOM TRAINING DRIVES SELF- IMPROVEMENT AND ADJUNCTIVE TREATMENT WHEN APPLICABLE BACK-END SCREENING DRIVES DE- STIGMATIZATION, PREVENTION AND COMPLIANCE FOR THOSE AT-RISK CONTINUOUSLY DRIVE AWARENESS WITH HEALTH MONITORING AND CAPACITY TRAINING
  12. 12. Benefits for Employees and Their Companies MENTAL HEALTH IMPROVEMENT MENTAL HEALTH INSIGHTS MENTAL CONDITION SCREENING SELF AWARENESS Strengths, weaknesses, conditions Emotion Feeling Thinking Self Control +15% +15% +9% +11 IMPROVED PERFORMANCE1 EFFECTIVENESS MONITORING Mental fitness programs and treatment POPULATION ANALYTICS Brain performance, mental condition prevalence PERFORMANCE ANALYSIS By service provider, function and geography CONFIDENTIALLY SCREEN 7 common mental conditions TAKE ACTION EAP or other health service HEALTH COST REDUCTION 55% of registered users screen and 66% are at risk.. $6,390 in savings per year for each successful treatment2. MENTAL HEALTH CLAIMS REDUCTION 38% reduction for the 25% most vulnerable population3 INCREASED PRODUCTIVITY 7.15% productivity gains on average4 SIGNIFICANT ROI Average of over 7x ROI from productivity gains5 Sources: 1. Improvements in brain performance correlated with average of three hours of training. 2017 internal book of business data; N = 3,275; Users who assessed+ trained at least twice 2. $6,390 in healthcare cost according to BCBS, The Health of America, “Major Depression: The Impact on Overall Health”, May 2018 3. A group analysis in a major U.S. technology company showed that, for its 24% most vulnerable population (those employees with the poorest sustained attention), brain training corresponded with a 38% reduction in pharmaceutical medical claims: $600 in annual savings per employee, if we assume constant trainingor long lasting effect of 2-monthtraining. 4. Improvements in brain performance correlated with average of three hours of training. 2017 internal book of business data; N = 3,275; Users who assessed+ trained at least twice 5. Based on 2017 internal book of business data 14
  13. 13. Q & A 15
  14. 14. THANKS! 16
  15. 15. Benefits of Cognitive Training on Brain Connectivity and Neuropsychological Measures in Adolescents with Learning Disabilities Gregory Rose, Ph.D.1 Audreyana Jagger, Ph.D.2 1Departments of Anatomy and Physiology, School of Medicine 2Department of Psychology Southern Illinois University Carbondale, IL USA
  16. 16. Goal and Approach of Our Work Goal • Explore the utility of Arrowsmith brain training for improving academic performance in students with learning disabilities Research Approach • Define differences in brain function between students enrolled in the Arrowsmith program and their typically developing counterparts using • Functional magnetic resonance imaging (fMRI) • Neuropsychological testing • Determine whether there are changes in fMRI or neuropsychological measures as a function of Arrowsmith training
  17. 17. What is Arrowsmith Training? • Arrowsmith is a set of exercises developed to improve brain function in students with complex learning disabilities. • See www.arrowsmithschool.org for details. • After assessment in up to 19 different functional areas, each student is given a customized learning program. • Students progress through sets of exercises of increasingly difficulty to address their specific deficit areas, and must meet milestones in order to progress. • The goal of Arrowsmith training is to permanently improve cognitive performance.
  18. 18. Using fMRI to Measure Connectivity Between Brain Regions The Discovery of Resting State Networks • The brain is ~2% of the body by weight, but it uses about 20% of the body’s oxygen supply, even at “rest”. • Task-based MRI studies typically see signal changes of only 1-5%. • How to explain these seeming discrepancies? • Biswal et al. (1995) were the first to describe coordinated low-frequency (0.01 – 0.1 Hz) oscillations in fMRI signals between distinct brain regions under task-free conditions. Raichle, Brain Connect. 2011 The Brain is Always Active:
  19. 19. Many Resting State Networks Identified At least a dozen separate resting state networks have been found Raichle, Brain Connect., 2011 Distinct brain regions show both correlated and anti-correlated activity Fox et al., PNAS, 2005
  20. 20. Why Focus on Resting State Networks? • Relatively easy acquire information • MRI scanner needed, but no additional equipment • Rapid procedure that is easily standardized • Minimal demands on subjects • Can assess multiple networks simultaneously • Well suited for repeated assessments • Predictive power R e la tiv e R e s tin g D M N C o n n e c tiv ity Memory(%Correct) 0 2 4 6 8 7 0 8 0 9 0 1 0 0 1 1 0 r 2 = 0 .6 0 p = 0 .0 1 4 Hampson et al., J. Neurosci., 2006 Seeley et al., J. Neurosci., 2007
  21. 21. Four Networks We Are Focusing On Default Mode Dorsal Attention Salience Fronto-Parietal (Executive) Control We are interested in the strength of connections within a particular network, as well as the connections between networks. “I’m thinking” “What’s going on?” “What’s important?” “How should I respond?”
  22. 22. Network Connectivity is Altered in Arrowsmith Students Compared to Typically Developing Controls Red lines indicate connections that are stronger, and blue lines weaker, in Arrowsmith students
  23. 23. Hyperconnectivity Between Networks Seen in Arrowsmith Students * p < 0.05 0 0.1 0.2 0.3 0.4 0.5 0.6 0.7 DMN DAN SN FPCN mean ConnectivityValue Within Network Connectivity Control Arrowsmith 0 0.02 0.04 0.06 0.08 0.1 0.12 0.14 0.16 DMN DAN SN FPCN mean ConnectivityValue Between Network Connectivity Control Arrowsmith * * * *
  24. 24. What are the Effects of Arrowsmith Training? Summer Cognitive Intensive Program offers a good way to begin to explore this question. • All students are trained on the Symbol Relations Task • Training is intensive, up to five hours/day, in 30-40 minute blocks, for six weeks • Task becomes progressively more difficult • Progress contingent upon 90% performance accuracy at a given level
  25. 25. Variable Improvement in Symbol Relations Performance S ta rt F in is h 0 2 4 6 8 1 0 1 2 G ro u p M e a n s SymbolRelationsScore *** * S ta rt F in is h 0 2 4 6 8 1 0 1 2 In d iv id u a l P e rfo rm a n c e SymbolRelationsScore ****p < 0.0001
  26. 26. Symbol Relations Training Strengthens Network Connectivity Warmer colors indicate relatively stronger increases in connectivity between network components. Changes are proportional to Symbol Relations improvement. Most of the of involved sites are within and between the Default Mode and Salience networks.
  27. 27. 450 460 470 480 490 500 510 520 530 WScore Star t * *** Symbol Relations Training Improves Woodcock-Johnson IV COG Performance Overall p < 0.005; *p < 0.05 for individual tests WJ IV ACHWJ IV COG
  28. 28. Connectivity Changes After One Academic Year of Arrowsmith Training Overall, the effect of Arrowsmith exercises is to reduce the hyperconnectivity between brain regions seen before training.
  29. 29. 450 460 470 480 490 500 510 520 530 WScore Start End * ** * * * * * * * * * * Improvements in WJIV Cognitive and Achievement Tests Seen After One Academic Year of Arrowsmith Training Overall p < 0.0001; * = p < 0.05 for individual tests WJ IV COG WJ IV ACH
  30. 30. Summary • Arrowsmith students are a heterogeneous group with academic performance deficits. • Brain network connectivity in Arrowsmith students is altered • In general, between-network connections are stronger (hyperconnectivity) • Connections within the salience network tend to be weaker • Intensive training in the Arrowsmith CIP Symbol Relations task strengthens network connectivity • The change is proportional to improvement over the training interval • The salience network is particularly affected • Academic year participation in the Arrowsmith program reduces the hyperconnectivity observed prior to training • Arrowsmith training improves performance in Woodcock-Johnson tests of cognition and achievement
  31. 31. Future Directions Key Questions • Does Arrowsmith training cause lasting changes in brain function? • What are the effects of Arrowsmith training on “real world” measures of academic performance? • Could Arrowsmith training be beneficial for other individuals with cognitive impairments (e.g., traumatic brain injury, age-related impairments)? • Could Arrowsmith training improve the academic performance of typically developing controls?
  32. 32. ChooseMuse.comChooseMuse.com How to promote brain health at scale: EEG and Meditation Ariel Garten Founder, Muse ariel@choosemuse.com Twitter @choosemuse Insta ariels_musings
  33. 33. Brain Health @ choosemuse ChooseMuse.com
  34. 34. What is meditation / mindfulness @ choosemuse ChooseMuse.com med·i·ta·tion A practice or training that cultivates healthy and positive mind states
  35. 35. What is meditation / mindfulness @ choosemuse ChooseMuse.com med·i·ta·tion A practice or training that cultivates healthy and positive mind states mind·ful·ness Intentionally maintaining a non-judgemental, moment-by-moment awareness of our thoughts, feelings, bodily sensations, and surrounding environment.
  36. 36. MAYO CLINIC Productivity: Teams that established a mindfulness-based meditation practice within an organisation showed 10% increase in work performance from employees (6). Stress: Hundreds of articles demonstrate the effects of meditation of stress. 8 weeks meditation showed a significant decrease stress (3), and increased ability to manage negative thoughts (4). Attention: 10-day mindfulness training increased working memory capacity during tasks, and longer sustained attention during tasks (5). (1)JAMA Internal Medicine (2)New York Academy of Sciences (3)Contemporary Nursing (4)JAMA Internal Medicine (5)Cognitive Therapy and Research (6) Neuroimage (7) Mindfule Work A technique validated in 1000 + journal articles
  37. 37. Health: Individuals that practiced relaxation- response techniques, such as meditation and yoga, showed a 43% decrease in healthcare utilization (1). And decreased absenteeism at work (7) Sleep: Older adults in 6- week mindfulness-based sleep program had significant improvement on insomnia symptoms and fatigue severity (1). Pain: Individuals with chronic pain showed a 57% decrease in pain after 8- week mindfulness-based pain reduction program (2). Experienced meditators showed a 90% decrease in pain symptoms (2) Aging: The brains of regular meditators in their 50s were estimated to be 7.5 years younger than non-meditators of the same age, shown by a larger volume of grey matter in the Prefrontal Cortex (6). A technique validated in 1000 + journal articles MAYO CLINIC
  38. 38. @ choosemuse ChooseMuse.com
  39. 39. @ choosemuse ChooseMuse.com
  40. 40. @ choosemuse ChooseMuse.com Barriers to Meditation Adoption
  41. 41. Muse for Meditation @ choosemuse ChooseMuse.com
  42. 42. When you're calm you’ll hear peaceful weather sounds When your mind wanders the weather will intensify and gently guide you back to a calm state. While you are meditating, you actually hear the sound of your own mind Muse Meditation @ choosemuse ChooseMuse.com
  43. 43. See your data, track, build and improve. @ choosemuse ChooseMuse.com Calibrate1 Relax2 Data3
  44. 44. @ choosemuse ChooseMuse.com Tens of thousands of lives, all over the globe.
  45. 45. Body: Building the foundation of stillness
  46. 46. Breath: Riding breath to a deeper practice
  47. 47. Heart: Learn your rhythm, find your calm
  48. 48. Muse Connect
  49. 49. Neuroscience of mindfulness @ choosemuse ChooseMuse.com
  50. 50. Neuroscience of mindfulness @ choosemuse ChooseMuse.com Meditation: Down regulates Amygdala
  51. 51. Neuroscience of mindfulness @ choosemuse ChooseMuse.com Meditation: Thickens the Pre Frontal Cortex Dr Sarah Lazar
  52. 52. Neuroscience of mindfulness @ choosemuse ChooseMuse.com Meditation: Increases volume of Left Hippocampus
  53. 53. Neuroscience of mindfulness @ choosemuse ChooseMuse.com Meditation: Increases Density of Grey Matter
  54. 54. Neuroscience of mindfulness @ choosemuse ChooseMuse.com Meditation: Impacts Temporal Parietal Junction
  55. 55. MIT Machine learning w/EEG to classify brain states
  56. 56. • Can we improve quality of life for cancer patients with Muse? • Muse delivered 3-5 weeks pre- surgery & used daily at home, then approx. 2 weeks post- surgery • Follow up measures include QOL psychometrics + standard- of-care metrics Muse Study in Process at Mayo Clinic @ choosemuse ChooseMuse.com
  57. 57. @ choosemuse ChooseMuse.com Baycrest Results • Average subject • 10 minutes of Musing per day • 6 weeks duration
  58. 58. @ choosemuse ChooseMuse.com Baycrest Results • Decrease in somatic symptoms (BSI) • Increase in sensation of calm • Improvement in cognitive performance in stressful situations
  59. 59. BLUE
  60. 60. BLUE
  61. 61. Mindfulness in Sports @ choosemuse ChooseMuse.com
  62. 62. Meditation in the workplace people meditating in business settings - maybe a large image that takes up whole slide? Meditation in the Workplace @ choosemuse ChooseMuse.com
  63. 63. @ choosemuse ChooseMuse.com
  64. 64. @ choosemuse ChooseMuse.com
  65. 65. Ariel Garten ariel@choosemuse.com Twitter: @ariel_garten @choosemuse Instagram: ariels_musings Brain & Meditation Podcast: Untangle
  66. 66. Access recorded talks, Q&A, and more at: SharpBrains.com

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