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How can we harness digital technologies and artificial intelligence (AI)
to upgrade research, assessments and intervention...
November 2017
HOW CAN WE HARNESS DIGITAL TECH AND AI TO SCALE UP
BRAIN RESEARCH, ASSESSMENTS AND INTERVENTIONS?
Dr. Oliver...
November 2017
Psychiatrist
Computational
Neuroscience
Central London
Six years
Director of Public
Health
Abu Dhabi
Seven y...
Barcelona, 24 May 2017
• ±350 million clients
• 25 countries
• Connectivity provider
(foundation layer)
• $1bn annual R&D
Barcelona, 24 May 2017
Huge problem
Radical
solution
Breakthrough
technology
November 2017
IF IT AIN’T BROKE,
DON’T FIX IT
Well, Mental Healthcare is
broken... how can we fix it?
1 in 4 every year
November 2017
DIGITAL CAVALRY COMING TO HEALTHCARE… FINALLY
VR, AR, ER
BLOCKCHAIN
DATA + MACHINE LEARNING
DIGITAL HEALTH
November 2017
Evolving tools
Mental health today
Shaping forces
Mental health in future?
OUR IMMEDIATE CHALLENGE
Future me...
November 2017
WORLDWIDE, HEALTHCARE IS COMPLEX AND POLITICAL
$3.2tn USA, $10.3tn Worldwide
November 2017
LESSON FROM NATURE – FIND THE RIGHT VECTOR
November 2017
WORKING WITH YOU
Research Platform – coming in 2018…
Tools – data analysis, behaviour change tools
November 2017
www.alpha.company
Pascal Weinberger
Our contact for rapid prototyping
pascal.weinberger@telefonica.com
©2017 Digital Cognition Technologies, Inc. Company confidential & proprietary.
Nancy Briefs, MBA
President & CEO
16
©2017 Digital Cognition Technologies, Inc. All Rights Reserved.
Our Story
Transform well known tests into objective, qu...
17
©2017 Digital Cognition Technologies, Inc. All Rights Reserved.
New Cognitive Measurement Platform
CognitionParkinson’s...
18
©2017 Digital Cognition Technologies, Inc. All Rights Reserved.
Today’s Standard for Cognitive Assessment
• Paper and p...
19
©2017 Digital Cognition Technologies, Inc. All Rights Reserved.
Lead Product: DCTclock™
DCT proprietary test
form + dig...
20
©2017 Digital Cognition Technologies, Inc. All Rights Reserved.
Robust Database
• Machine Learning algorithms trained a...
21
©2017 Digital Cognition Technologies, Inc. All Rights Reserved.
Classify
via AI
Feature
measurements
Report
via ML
Prop...
22
©2017 Digital Cognition Technologies, Inc. All Rights Reserved.
DCTclock™ Excels as a General Assessment
Removed highly...
23
©2017 Digital Cognition Technologies, Inc. All Rights Reserved.
Distinguishes Disease Stages
- 23 -
24
©2017 Digital Cognition Technologies, Inc. All Rights Reserved.
Association with ApoE Genetic Risk and MRI
• DCTclock S...
25
©2017 Digital Cognition Technologies, Inc. All Rights Reserved.
Better Correlation with Biomarkers
- 25 -
Amyloid (glob...
26
©2017 Digital Cognition Technologies, Inc. All Rights Reserved.
… works
… is fast, inexpensive, culture fair, scalable,...
27
©2017 Digital Cognition Technologies, Inc. All Rights Reserved.
Questions
nbriefs@digitalcogtech.com
Emma Yang
@emmayang78
emmayang.com
• 13 Years Old, 9th Grader
• Founder of Timeless
• Co-Founder of Food4Thought
2017 2050
50M
130M
Alzheimer’s Disease –The Prevalence
The Challenges Alzheimer’s Patients Face
• Remembering events
• Taking in new information
• Recognizing people & places
• ...
A real life example
Lack of Solutions
There are many
tools in the market
but none of them
help the patients
improve their daily
lives
A First of its kind, Simple,
Easy to use App For Alzheimer’s
and Dementia patients to remember
events, stay connected and ...
Updates Today Contacts Identify
Timeless
Network of Sponsors and Mentors
Dr. Melissa Kramps
New York-Presbyterian Hospital
Partner AND
Expert
Support
Liliia Mandri...
Worldwide Press Coverage
USA BBC World Service
Malaysia
Spain
Wide Reach on Social Media
Over 33K views on
the demo video
Development Progress
MVP
ROLLOUT
ENHANCE
PILOT
Location
Tracking
Gamification Augmented
Reality
Product Roadmap
Collaboration
Scale
Adoption
What I need
Empower the last generation!
Timeless
@timeless_ai
@app.timeless
timeless.care
Thank You
Big data provides new insights into
learning outcomes
Belén Guerra-Carrillo
Doctoral Candidate
Psychology Department, UC B...
Technology enables us to measure the cognitive
effects of prolonged enriching experiences
Education is a long-lasting multifaceted experience
Does education hone cognitive functioning and
learning efficacy?
Higher educational attainment associated with
better performance across the age range
Educational attainment moderates the age of
peak cognitive performance
Education explains greater variance in
performance on more cognitively complex tasks
Task pictures from www.lumosity.com
Minimal effect of educational attainment on novel
learning
Conclusions
Thank you!
Collaborators
Thank you, Speakers & Participants!
Thank you, Summit Sponsors!
Thank you, Summit Partners!
To learn more, visit sharpbrains.com
How can we harness digital technologies and artificial intelligence (AI) to scale up brain research, assessments and inter...
How can we harness digital technologies and artificial intelligence (AI) to scale up brain research, assessments and inter...
How can we harness digital technologies and artificial intelligence (AI) to scale up brain research, assessments and inter...
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How can we harness digital technologies and artificial intelligence (AI) to scale up brain research, assessments and interventions?

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*Dr. Oliver Harrison. Chief Executive of the Health Moonshot at Telefónica Innovation
*Nancy Briefs, President and CEO of Digital Cognition Technologies
*Emma Yang, 9th grader, Creator of Timeless app and MIT Solver
*Belén Guerra-Carrillo, NSF Fellow and graduate student researcher at University of Califonia, Berkeley
*Chaired by: Kayt Sukel, science writer

*Álvaro Fernández, CEO and Editor-in-Chief of SharpBrains
*Sarah Lenz Lock, Senior Vice President for Policy at AARP and Executive Director of the Global Council on Brain Health (GCBH)
*Dr. April Benasich, Director of the Baby Lab at the Rutgers Center for Molecular and Behavioral Neuroscience
*Chaired by: Dr. Cori Lathan, Co-Chair of the World Economic Forum’s Council on the Future of Human Enhancement

Slidedeck supporting session held during the 2017 SharpBrains Virtual Summit: Brain Health & Enhancement in the Digital Age (December 5-7th). Learn more at: https://sharpbrains.com/summit-2017/

Published in: Science
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How can we harness digital technologies and artificial intelligence (AI) to scale up brain research, assessments and interventions?

  1. 1. How can we harness digital technologies and artificial intelligence (AI) to upgrade research, assessments and interventions? Dr. Oliver Harrison. Chief Executive of the Health Moonshot at Telefónica Innovation Belén Guerra-Carrillo, NSF Fellow and graduate student researcher at University of Califonia, Berkeley Nancy Briefs, President and CEO of Digital Cognition Technologies Emma Yang, 9th grader, Creator of Timeless app and MIT Solver Chaired by: Kayt Sukel, science writer
  2. 2. November 2017 HOW CAN WE HARNESS DIGITAL TECH AND AI TO SCALE UP BRAIN RESEARCH, ASSESSMENTS AND INTERVENTIONS? Dr. Oliver Harrison
  3. 3. November 2017 Psychiatrist Computational Neuroscience Central London Six years Director of Public Health Abu Dhabi Seven years Health Tech + Public-Private Partnerships Worldwide Five years SVP, Business Development Worldwide Two years Tech CEO Worldwide Ongoing PERSONAL JOURNEY
  4. 4. Barcelona, 24 May 2017 • ±350 million clients • 25 countries • Connectivity provider (foundation layer) • $1bn annual R&D
  5. 5. Barcelona, 24 May 2017 Huge problem Radical solution Breakthrough technology
  6. 6. November 2017 IF IT AIN’T BROKE, DON’T FIX IT Well, Mental Healthcare is broken... how can we fix it? 1 in 4 every year
  7. 7. November 2017 DIGITAL CAVALRY COMING TO HEALTHCARE… FINALLY VR, AR, ER BLOCKCHAIN DATA + MACHINE LEARNING DIGITAL HEALTH
  8. 8. November 2017 Evolving tools Mental health today Shaping forces Mental health in future? OUR IMMEDIATE CHALLENGE Future mental health The WPA-Lancet Psychiatry Commission on the Future of Psychiatry; Lancet, October 2017
  9. 9. November 2017 WORLDWIDE, HEALTHCARE IS COMPLEX AND POLITICAL $3.2tn USA, $10.3tn Worldwide
  10. 10. November 2017 LESSON FROM NATURE – FIND THE RIGHT VECTOR
  11. 11. November 2017 WORKING WITH YOU Research Platform – coming in 2018… Tools – data analysis, behaviour change tools
  12. 12. November 2017 www.alpha.company Pascal Weinberger Our contact for rapid prototyping pascal.weinberger@telefonica.com
  13. 13. ©2017 Digital Cognition Technologies, Inc. Company confidential & proprietary. Nancy Briefs, MBA President & CEO
  14. 14. 16 ©2017 Digital Cognition Technologies, Inc. All Rights Reserved. Our Story Transform well known tests into objective, quantified metrics of cognitive function that can detect pre-symptomatic change • Experienced Team • 12+ years development • Clinically Validated • Seminal IP Exclusively licensed • Applying AI to “gold standard” tests • $1.9B+ market opportunity • Currently deployed in >20 sites with Pharma Partners • Commercial 2018 with Neuro-Specialists Cognitive Assessment and Training – Global Forecast to 2021, MarketsandMarkets
  15. 15. 17 ©2017 Digital Cognition Technologies, Inc. All Rights Reserved. New Cognitive Measurement Platform CognitionParkinson’s Disease Multiple Sclerosis Vascular Dementia Lewy Body Disease Traumatic Brain InjurySleep Disorders Huntington’s Disease Medication Effects Surgical Effects Anesthetics Effects Chemotherapy EffectsAlzheimer’s Disease Dementia Healthy Aging Discriminating technology has myriad applications for measuring cognitive function and detecting subtle change Child Development
  16. 16. 18 ©2017 Digital Cognition Technologies, Inc. All Rights Reserved. Today’s Standard for Cognitive Assessment • Paper and pencil test • 10 – 20 minutes admin • Physician must administer • Results depend on observation and subjective assessment • Inherent bias • Insensitive to mild impairment Biases: hearing and visually impaired, intubated, low English literacy, communication disorders, age, culture, language, education https://www.mountsinai.on.ca/care/psych/on-call-resources/on-call-resources/mmse.pdf https://www.alz.org/documents_custom/141209-CognitiveAssessmentToo-kit-final.pdf
  17. 17. 19 ©2017 Digital Cognition Technologies, Inc. All Rights Reserved. Lead Product: DCTclock™ DCT proprietary test form + digital pen Encrypted data Transmitted over cloud Proprietary algorithms Actionable reports and referrals camera
  18. 18. 20 ©2017 Digital Cognition Technologies, Inc. All Rights Reserved. Robust Database • Machine Learning algorithms trained against Lahey Clinic and Framingham Heart Study • Clinically validated technology Graphics: created by Rockicon from Noun Project Normative Sample • 1,530 individuals • Framingham Heart Study: testing since 2011 • Cognitively healthy by consensus diagnosis at time of testing Clinical Sample • 1,382 individuals • Referred for cognitive or neurological complaints • Cognitive impairment by consensus diagnosis at time of testing
  19. 19. 21 ©2017 Digital Cognition Technologies, Inc. All Rights Reserved. Classify via AI Feature measurements Report via ML Proprietary Algorithms
  20. 20. 22 ©2017 Digital Cognition Technologies, Inc. All Rights Reserved. DCTclock™ Excels as a General Assessment Removed highly impaired – analysis on mildly impaired segment only. AUC is the accuracy of distinguishing healthy from impaired measured by the area under the ROC curve. 1 represents a perfect test; an area of .5 represents a worthless test. A rough guide: Excellent (.9-1), Good (.8-.9), Fair (.7-.8), Poor (.6-.7), Fail (.5-.6) Detects Mild Impairment Better • Area Under the Curve (AUC) is a measure of accuracy • The closer to 1 the more accurate • Chart shows only MMSE > 26 • DCTclock’s AUC is highest at .83 DCTclock Score (.83) MMSE Score (.72) MoCA clock (.66) MiniCog clock (.62)
  21. 21. 23 ©2017 Digital Cognition Technologies, Inc. All Rights Reserved. Distinguishes Disease Stages - 23 -
  22. 22. 24 ©2017 Digital Cognition Technologies, Inc. All Rights Reserved. Association with ApoE Genetic Risk and MRI • DCTclock Score (p=0.004) and multiple Composite Scales differentiated high and low risk groups • 1220 Dementia and stroke-free FHS participants genotyped for ApoE classified into risk groups: – High (ApoE4+, n=261) – Low (ApoE4-, n=931) • DCTclock Score showed significant positive association with overall gray matter volume and specific regions • 454 dementia and stroke-free Framingham Heart Study (FHS) participants with MRI
  23. 23. 25 ©2017 Digital Cognition Technologies, Inc. All Rights Reserved. Better Correlation with Biomarkers - 25 - Amyloid (global PiB) Entorhinal Tau DCTclock Sel. Remind. MMSE Trails A
  24. 24. 26 ©2017 Digital Cognition Technologies, Inc. All Rights Reserved. … works … is fast, inexpensive, culture fair, scalable, broadly applicable, provides a global platform Early detection is empowering Slowing disease progress is extraordinarily valuable Our Solution
  25. 25. 27 ©2017 Digital Cognition Technologies, Inc. All Rights Reserved. Questions nbriefs@digitalcogtech.com
  26. 26. Emma Yang @emmayang78 emmayang.com • 13 Years Old, 9th Grader • Founder of Timeless • Co-Founder of Food4Thought
  27. 27. 2017 2050 50M 130M Alzheimer’s Disease –The Prevalence
  28. 28. The Challenges Alzheimer’s Patients Face • Remembering events • Taking in new information • Recognizing people & places • Separating fact from fiction
  29. 29. A real life example
  30. 30. Lack of Solutions There are many tools in the market but none of them help the patients improve their daily lives
  31. 31. A First of its kind, Simple, Easy to use App For Alzheimer’s and Dementia patients to remember events, stay connected and engaged with friends and family, and to recognize people through artificial intelligence based facial recognition technology
  32. 32. Updates Today Contacts Identify Timeless
  33. 33. Network of Sponsors and Mentors Dr. Melissa Kramps New York-Presbyterian Hospital Partner AND Expert Support Liliia Mandrino Human Experience Designer
  34. 34. Worldwide Press Coverage USA BBC World Service Malaysia Spain
  35. 35. Wide Reach on Social Media Over 33K views on the demo video
  36. 36. Development Progress MVP ROLLOUT ENHANCE PILOT
  37. 37. Location Tracking Gamification Augmented Reality Product Roadmap
  38. 38. Collaboration Scale Adoption What I need
  39. 39. Empower the last generation!
  40. 40. Timeless @timeless_ai @app.timeless timeless.care
  41. 41. Thank You
  42. 42. Big data provides new insights into learning outcomes Belén Guerra-Carrillo Doctoral Candidate Psychology Department, UC Berkeley 2017 SharpBrains Virtual Summit
  43. 43. Technology enables us to measure the cognitive effects of prolonged enriching experiences
  44. 44. Education is a long-lasting multifaceted experience
  45. 45. Does education hone cognitive functioning and learning efficacy?
  46. 46. Higher educational attainment associated with better performance across the age range
  47. 47. Educational attainment moderates the age of peak cognitive performance
  48. 48. Education explains greater variance in performance on more cognitively complex tasks Task pictures from www.lumosity.com
  49. 49. Minimal effect of educational attainment on novel learning
  50. 50. Conclusions
  51. 51. Thank you! Collaborators
  52. 52. Thank you, Speakers & Participants!
  53. 53. Thank you, Summit Sponsors!
  54. 54. Thank you, Summit Partners!
  55. 55. To learn more, visit sharpbrains.com

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