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2. ASEAN Contaminants & Analytical Methods 2012


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Food Industry Summit organised by Food Industry Asia ( : 06 September 2012

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2. ASEAN Contaminants & Analytical Methods 2012

  1. 1. CASE STUDY 3:Contaminants &Analytical Methods- Ruowei Strange- Lionel Buratti
  2. 2. Contaminant Limits & Analytical Methods PART TWO Lionel Buratti
  3. 3. ANALYTICAL METHODS …AS HIDDEN TBTA further complication is that in some cases there areno internationally accepted ways of testing for certaincontaminants.Heavy metals can be analysed using severaltechniques with different limits of detection (LoD). For example, most laboratories across ASEAN use the Flame AAS method for lead detection, althoughthe more modern ICP-MS technology enables moreaccurate and automated
  4. 4. ANALYTICAL METHODS …AS HIDDEN TBT There is little consensus across ASEAN on which methods to use, and companies face disputes within the sector itself (supplier-customer) and with regulatory bodies due to discrepancies in analytical results. Manufacturers, suppliers and regulators can be confronted with different analytical results obtained from different analytical techniques and equipment in different laboratories and
  5. 5. ANALYTICAL METHODS …AS HIDDEN TBTScientifically, this arises from the complexityof sample matrixes and the variation inanalytical methods - measurementuncertainty (MU)- stating that no measurement is exact.When a quantity is measured, the outcome depends onthe measuring system, the measurement procedure, theskill of the operator, the environment, and other effects.Usually in labs, we use the following criterias:• repeatability (r), i.e. Same analyst doing the test twice• reproducibility (R), i.e. Two analysts doing the test with the same method on different days /
  6. 6. ANALYTICAL METHODS …AS HIDDEN TBT Disputes are most notable when analytical results are near to specification or regulatory limits. For example, it is not easy to ascertain the accurate (True value) of lead results at 1.0 mg/kg by AAS and ICP-MS with precision as follows: By AAS : r <27% R <50% By ICP-MS : r <13% R < 7
  7. 7. R<50% r<27% AAS 0 mg/kg 1.0 mg/kg 0.8 mg/kg 0.67 mg/kg R<32% r<13% ICP-MS 0 mg/kg 1.0 mg/kg 0.89 mg/kg 0.76 mg/kg NB: with excellent Laboratory Practice (GLP), r & R can be reduced in both methods but will still be matrices
  8. 8. QUESTIONS TO YOU…• Are you facing the same challenges?• Is this discussed with your customer / authorities when testing differences arises?• Often a 3rd-party independent lab is used to settle the case but it doesn’t resolve the situation as this 3rd- party lab is facing the same difficulties (r&R) – would it not be better to agree first on a testing method (preferably international) and associated acceptable r&R? how could we move this forward? …PLEASE SHARE WITH 9