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MICROENCAPSULATION,
HOW TO PROGRESS FROM COSMETOTEXTILES
TO MEDICAL DEVICES ?
17th International Convention on Bioencapsulation - Brussels - April 23-25, 2014
Few words about cosmetotextiles (CT)
 Textiles + cosmetics + capsules
 From textile to CT
1998: DIM moisturizing panty hose (aminoplast capsules)
Do not reproduce without written authorization
 After 15 years, recognized actors:
Lytess, Blondel, Skin’up, Biotherm, Mixa …
Few words about cosmetotextiles (CT)
 Changes occured in market & consumers
 Ruptures made
Scientific and technical (touch, color…)
Regulation (e.g. forbidden raw materials)
normalization (2009)
 Real progress
 Know-how acquired
Do not reproduce without written authorization
Know-how acquired on CT
Capsules
Content
Shell materials
Technologies: aminoplast, PU, PA…
Do not reproduce without written authorization
Deposit techniques (padding, coating,
exhaustion…)
Both on made-up articles and fabrics
Responding to the new existing standard
What is a CT?
Active release
and diffusion
on skin
Active substances
Microencapsulation
Bonding on textile
Do not reproduce without written authorization
Microencapsulation for CT
Adapt existing microcapsules to constraints of textile processes
 very low overhead
 Øcapsule < Øfiber (for strong grip)
 water insolubility (aqueous processes)
 controlled release
 shell material physico-chemistry (zeta potential, compatibility with chemicals involved
in textile industry…)
 textile treatment resistance (mechanical and temperature)
 Techniques: aminoplast, gelatin, PA, PU (in minority)
Textile fiber (5 - 40 µm)
Microcapsule (5 µm)
Binder (attachment and durability)
Do not reproduce without written authorization
Major issues in CT
 Mostly linked to safety : normalization CEN / TR 15917:2009
 ↘ toxicity (blacklist, residues, no formaldehyde or glutaraldehyde)
 ↗ biocompatibility of raw materials used in textile industry (ennobling
products: binders, softeners, dyes… )
 Improve encapsulation processes for watersoluble actives
 Develop smart « raw materials »
 controlled release, responding to stimuli…
 Works on both microcapsules and textiles processes
Do not reproduce without written authorization
Work in progress
Encapsulation-textiles processes
 Safe, green technologies, minimizing secondary/chemical products
 Safe raw materials
 Vegetal: oils, waxes
 Animal: chitosan, mostly biocompatible polymers (synthetics)
 Cosmetic and pharma additives: binders, wetting agents, softeners…
New « smart » shell materials
 Providing release controlled by pH, tº, humidity, interactions with skin/others
compounds...
Do not reproduce without written authorization
Work in progress (con’t)
Encapsulation of watersoluble actives
 Fit textile constraints (economically and technically)
 In conformity towards future regulation and safety rules (solvents)
Involved quantities
 Measurements: Intertek, Bureau Véritas, Spin control, Dermscan
 Control of deposited and released dose
Do not reproduce without written authorization
 Compatibility with textile processes
 Efficiency / durability
 Textile properties (aspect, touch, color)
To go further…
 Improvements (processes, products)
 New works and developments…
Textiles
Medical devices
Cosmetotextiles
?
Do not reproduce without written authorization
What is a medical device (MD)?
Medical device (according to ANSM and FDA):
 any instrument, apparatus, appliance, software, material or other article, whether
used alone or in combination
 human use for: treatment or alleviation of disease, diagnosis, monitoring, treatment,
compensation for an injury or handicap, study, replacement or modification of the
anatomy or of a physiological process… (EC Directive 93/42/EEC )
 examples: contact lenses, thermometers, compresses, external defibrillators,
stents, hip prostheses, medical beds...
Do not reproduce without written authorization
Non-invasive MD = delivering device
Therapeutical effect  treatment
Control of:
 Dose
 Release
 Use limits (wearing days…)
Dose
Time0 6 12
No effect
Therapeutic window
Toxic
0%
20%
40%
60%
80%
100%
0 5 10 15 20 25
Releaserate(%)
Number of use
Activerelease on skin
Do not reproduce without written authorization
Textile  CT  Medical device (MD)
MD
&
CT
SAFE
capsules
Deposit
process
Effect
Dose
- safe compounds:
binders, wetting agents …
- release management
- quantity vs. time

 
- no residues
- safe raw materials
CREATHES’
green technology
Do not reproduce without written authorization
Safe microcapsules for MD
Proprietary technology: 100% green process
 CREATHES is ready to go (capsules, technologies, methods…)
Capsules on textiles
(optical microscopy)
Do not reproduce without written authorization
Dermatextiles
 Skin pathology treatment (ichtyosis, eczema, atopy, xeroderma…)
 Wound care and dressing
 Post-surgery (hematoma, œdema…)
 Antiseptic properties, fight against nosocomial infections…
Applications
Do not reproduce without written authorization
5 rue Jacqueline Auriol 90 000 Belfort
France
+33 3 84 59 04 82
contact@creathes.com
www.creathes.com
 Our business Design and manufacture tailor-made Microcapsules
 Our mission Match innovation and market
 Our ethics Impact positively on consumer Health

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CREATHES : Microencapsulation from cosmetotextile to medical devices

  • 1. MICROENCAPSULATION, HOW TO PROGRESS FROM COSMETOTEXTILES TO MEDICAL DEVICES ? 17th International Convention on Bioencapsulation - Brussels - April 23-25, 2014
  • 2. Few words about cosmetotextiles (CT)  Textiles + cosmetics + capsules  From textile to CT 1998: DIM moisturizing panty hose (aminoplast capsules) Do not reproduce without written authorization  After 15 years, recognized actors: Lytess, Blondel, Skin’up, Biotherm, Mixa …
  • 3. Few words about cosmetotextiles (CT)  Changes occured in market & consumers  Ruptures made Scientific and technical (touch, color…) Regulation (e.g. forbidden raw materials) normalization (2009)  Real progress  Know-how acquired Do not reproduce without written authorization
  • 4. Know-how acquired on CT Capsules Content Shell materials Technologies: aminoplast, PU, PA… Do not reproduce without written authorization Deposit techniques (padding, coating, exhaustion…) Both on made-up articles and fabrics Responding to the new existing standard
  • 5. What is a CT? Active release and diffusion on skin Active substances Microencapsulation Bonding on textile Do not reproduce without written authorization
  • 6. Microencapsulation for CT Adapt existing microcapsules to constraints of textile processes  very low overhead  Øcapsule < Øfiber (for strong grip)  water insolubility (aqueous processes)  controlled release  shell material physico-chemistry (zeta potential, compatibility with chemicals involved in textile industry…)  textile treatment resistance (mechanical and temperature)  Techniques: aminoplast, gelatin, PA, PU (in minority) Textile fiber (5 - 40 µm) Microcapsule (5 µm) Binder (attachment and durability) Do not reproduce without written authorization
  • 7. Major issues in CT  Mostly linked to safety : normalization CEN / TR 15917:2009  ↘ toxicity (blacklist, residues, no formaldehyde or glutaraldehyde)  ↗ biocompatibility of raw materials used in textile industry (ennobling products: binders, softeners, dyes… )  Improve encapsulation processes for watersoluble actives  Develop smart « raw materials »  controlled release, responding to stimuli…  Works on both microcapsules and textiles processes Do not reproduce without written authorization
  • 8. Work in progress Encapsulation-textiles processes  Safe, green technologies, minimizing secondary/chemical products  Safe raw materials  Vegetal: oils, waxes  Animal: chitosan, mostly biocompatible polymers (synthetics)  Cosmetic and pharma additives: binders, wetting agents, softeners… New « smart » shell materials  Providing release controlled by pH, tº, humidity, interactions with skin/others compounds... Do not reproduce without written authorization
  • 9. Work in progress (con’t) Encapsulation of watersoluble actives  Fit textile constraints (economically and technically)  In conformity towards future regulation and safety rules (solvents) Involved quantities  Measurements: Intertek, Bureau Véritas, Spin control, Dermscan  Control of deposited and released dose Do not reproduce without written authorization  Compatibility with textile processes  Efficiency / durability  Textile properties (aspect, touch, color)
  • 10. To go further…  Improvements (processes, products)  New works and developments… Textiles Medical devices Cosmetotextiles ? Do not reproduce without written authorization
  • 11. What is a medical device (MD)? Medical device (according to ANSM and FDA):  any instrument, apparatus, appliance, software, material or other article, whether used alone or in combination  human use for: treatment or alleviation of disease, diagnosis, monitoring, treatment, compensation for an injury or handicap, study, replacement or modification of the anatomy or of a physiological process… (EC Directive 93/42/EEC )  examples: contact lenses, thermometers, compresses, external defibrillators, stents, hip prostheses, medical beds... Do not reproduce without written authorization
  • 12. Non-invasive MD = delivering device Therapeutical effect  treatment Control of:  Dose  Release  Use limits (wearing days…) Dose Time0 6 12 No effect Therapeutic window Toxic 0% 20% 40% 60% 80% 100% 0 5 10 15 20 25 Releaserate(%) Number of use Activerelease on skin Do not reproduce without written authorization
  • 13. Textile  CT  Medical device (MD) MD & CT SAFE capsules Deposit process Effect Dose - safe compounds: binders, wetting agents … - release management - quantity vs. time    - no residues - safe raw materials CREATHES’ green technology Do not reproduce without written authorization
  • 14. Safe microcapsules for MD Proprietary technology: 100% green process  CREATHES is ready to go (capsules, technologies, methods…) Capsules on textiles (optical microscopy) Do not reproduce without written authorization
  • 15. Dermatextiles  Skin pathology treatment (ichtyosis, eczema, atopy, xeroderma…)  Wound care and dressing  Post-surgery (hematoma, œdema…)  Antiseptic properties, fight against nosocomial infections… Applications Do not reproduce without written authorization
  • 16. 5 rue Jacqueline Auriol 90 000 Belfort France +33 3 84 59 04 82 contact@creathes.com www.creathes.com  Our business Design and manufacture tailor-made Microcapsules  Our mission Match innovation and market  Our ethics Impact positively on consumer Health