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3DS.COM©DassaultSystèmes|ConfidentialInformation|3/5/2015|ref.:3DS_Document_2014
Mathew Hahn, Ph.D., Ton van Daelen, Ph.D....
Industry Trends
• Number of new drugs
approved per billion US
dollars spent on R&D has
halved roughly every 9 years
since ...
Two Major Trends:
Shift towards biologics
Increased reliance on
external collaborations
External Collaboration Challenges
• Internal IT infrastructure not suitable for external projects
• Work is manual and err...
ScienceCloud
• A suite of cloud-based integrated apps able to interface with on-prem systems to
support networked scientif...
ScienceCloud Application Suite
Tasks
BTX.
WorkbenchBioReg
Notebook
Project
Data &
Documents
Analysis
ExchangeAuthoring
(Pi...
Challenges in Biologics Discovery
Innovation Barriers
• Lack of dedicated tools to:
• process and understand high volume
a...
BIOVIA Suite for Antibody R&D
Antibody
R&D
Analysis
Biotherapeutics
Workbench (BTx) Predictive
Analytics
Discovery
Studio
...
External Collaboration with Biologics
Notebook
Registration
1. Receive biologic (antigen) from
supplier
2. Register biolog...
Sign in to ScienceCloud
View Project Activity
Prepare for Registration
Pre-registration Validation
Automated Notification to Project Team
Partner: Create Experiment
Partner: Document Experiment
Partner: Analyze Clones
Analyze Clones
Cluster Clones Using Assay Data
Save Most Promising Candidates
Share, Report, Communicate
Wrap Up
• Effective external collaboration is key
success factor
• Biologics functionality has matured and
now available b...
Contact Info
• Visit us on the web at www.sciencecloud.com
• Find us on LinkedIn:
• Join the ScienceCloud LinkedIn Group: ...
ScienceCloud: Collaborative Workflows in Biologics R&D
ScienceCloud: Collaborative Workflows in Biologics R&D
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ScienceCloud: Collaborative Workflows in Biologics R&D

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The life sciences industry has undergone dramatic changes and effective global collaboration has become a key success factor in this new age. BIOVIA is providing a hosted and comprehensive solution stack for externalized, collaborative research for pharma/biotech and CROs to address these new challenges. Recently we added the support for biologics data management and IP capture. In this talk we will present collaborative and comprehensive capabilities in antibody characterization and development: capabilities to analyze, annotate and predict developability as part of a framework that facilitates secure data sharing and collaboration.

Published in: Software
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ScienceCloud: Collaborative Workflows in Biologics R&D

  1. 1. 3DS.COM©DassaultSystèmes|ConfidentialInformation|3/5/2015|ref.:3DS_Document_2014 Mathew Hahn, Ph.D., Ton van Daelen, Ph.D. BIOVIA ScienceCloud: Collaborative Workflows in Biologics R&D
  2. 2. Industry Trends • Number of new drugs approved per billion US dollars spent on R&D has halved roughly every 9 years since 1950 • Average cost of bringing a new drug to market: $2.6B* Nature Reviews Drug Discovery 11, 191-200 (March 2012) * ‘Cost to Develop and Win Marketing Approval for a New Drug’ Joseph A. DiMasi, director of economic analysis at Tufts CSDD, 2014
  3. 3. Two Major Trends: Shift towards biologics Increased reliance on external collaborations
  4. 4. External Collaboration Challenges • Internal IT infrastructure not suitable for external projects • Work is manual and error prone • Starting up / closing down projects can take months • Every collaboration is different / not clear where to go
  5. 5. ScienceCloud • A suite of cloud-based integrated apps able to interface with on-prem systems to support networked scientific workflows for all shapes of external collaborations A AA Transfer, Translate, Transform A Data Documents Context Integrated Apps API Social Mobile Security IntegrationAdmin Business rules Tech transfer Automation
  6. 6. ScienceCloud Application Suite Tasks BTX. WorkbenchBioReg Notebook Project Data & Documents Analysis ExchangeAuthoring (Pipeline Pilot) Search (Insight) Inventory (CisPro) Screening
  7. 7. Challenges in Biologics Discovery Innovation Barriers • Lack of dedicated tools to: • process and understand high volume antibody sequence data, assay data and cell line data together • assess developability early in the process • rapidly customize workflows • Integrate, process and report on data through all phases of the discovery process • Lack of real time project tracking and collaboration with internal and external partners • Lack of biologically aware and integrated: • registration system • sample and assay management systems • ELN and corporate databases • bioprocess systems • process optimization systems • regulatory quality and compliance systems Process Efficiency Barriers
  8. 8. BIOVIA Suite for Antibody R&D Antibody R&D Analysis Biotherapeutics Workbench (BTx) Predictive Analytics Discovery Studio Custom Workflows Pipeline Pilot Entity Mgmt Registration and Sample Laboratory Management ELN & EKB Process Knowledge Discoverant Innovation Barriers Process Efficiency Barriers
  9. 9. External Collaboration with Biologics Notebook Registration 1. Receive biologic (antigen) from supplier 2. Register biologic 3. Share with external partner 4. Request synthesis of hybridoma clones 4. Synthesize biologic 5. Document experiment in ScienceCloud Notebook 6. Send notification to pharma 7. Pick up synthesized clones 8. Merge with assay data 9. Analyze in BTX workbench (annotate cluster) 10. Share and report BTX Workbench
  10. 10. Sign in to ScienceCloud
  11. 11. View Project Activity
  12. 12. Prepare for Registration
  13. 13. Pre-registration Validation
  14. 14. Automated Notification to Project Team
  15. 15. Partner: Create Experiment
  16. 16. Partner: Document Experiment
  17. 17. Partner: Analyze Clones Analyze Clones
  18. 18. Cluster Clones Using Assay Data
  19. 19. Save Most Promising Candidates
  20. 20. Share, Report, Communicate
  21. 21. Wrap Up • Effective external collaboration is key success factor • Biologics functionality has matured and now available both on-prem and in the cloud • ton.vandaelen@3ds.com
  22. 22. Contact Info • Visit us on the web at www.sciencecloud.com • Find us on LinkedIn: • Join the ScienceCloud LinkedIn Group: ScienceCloud: Transforming Externalized Drug Discovery • Follow the BIOVIA page • To get in touch with a ScienceCloud team member, please click here

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