Infiltration of abnormal cells in the BM
Destruction and replacement of normal hematopoietic
Cytokines, GFs, other substances are released.
Premature release of immature cells.
Stem and progenitor cells migrate to the spleen and
Normocytic and normochromic
RBC and WBC precursors
A 46-year-old male patient presented with an 8 × 7-cm
ulcerated plaque on his chest, found to be morpheaform
basal cell on pathology. Laboratory findings were notable for
normocytic anemia, thrombocytopenia, and elevated LDH.
Further work up with bone marrow biopsy revealed tumor
cells. This confirmed the diagnosis of metastatic BCC
(MBCC) to bone marrow.
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Besa, Emmanuel, Ulrich Woermann, and C. Wullstein. "Myelophthisic
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Lichtin, A., “Myelophthisic Anemia.” (May 2013) Retrieved from
Pham CM, Syed AA, Siddiqui HA, Keller RA, Kowalewski C. “Case of metastatic
basal cell carcinoma to bone marrow, resulting in myelophthisic anemia.” (April
2013) Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/23147353