Nature perfected nano technology by evolution over millions of years. Current technology provides us the ability to engineer at nano meter level to mimic nature and develop nano technology enabled products. Nanomaterial, Nano medicine, Nano electronics and Nano engineered surfaces can revolutionize the industry for breakthrough products and economic development. The simulation based engineering design as a tool for cost effective Industrial innovation will be outlined. An overview of multiscale and multiphysics modeling to enable Nanotechnology Innovation will be given. Real life industrial examples to link nano discoveries to macro engineering applications for business benefit quantification will be detailed.