I will present several advances in deep learning from OpenAI. First, I will present OpenAI Five, a neural network that learned to play on par with some of the strongest professional Dota 2 teams in the world in an 18-hero version of the game. Next, I will present Dactyl, a human-like robot hand trained entirely in simulation with reinforcement learning that has achieved unprecedented dexterity on a physical robot. I will also present our results on unsupervised learning in language, that show that pre-training and finetuning can achieve a significant improvement over state of the art. Finally, I will present an overview of the historical progress in the field.