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Department Of Pharmaceutics 
Presented By : Guided By : 
Mr. Rohit U. Bharti Prof. R. S. Pentewar [HOD] 
ChannaBasweshwar Pharmacy College, Kava Road, Latur-413512. 
1 
07/02/2014 
Needle free Injection : 
Designed for Confidence
PRESENTATION OVERVIEW 
Introduction to Needle free injection 
State of the art technology 
Performance overview and past research 
Current applications 
 Products Available in Market 
Recent Technology and ongoing research 
References 
Questions 
2
WHAT IS IT ? 
3 
Needle-free injection systems are novel ways to introduce various 
medicines into patients without piercing the skin with a conventional 
needle. 
Needle-free injection techniques can be used to administer vaccines 
and medications in the pork industry. 
They are promoted as a possible option for patients with needle phobia
COMPONENTS 
4
5
Giving a Needle- free Injection[1] 
 Fill syringe with injectate 
Insert syringe into Biojector 
Hold at 90º with firm pressure at injection site 
Pull actuator, count to three, maintain pressure 
Remove device and hold pressure at site 
( patient or parent can hold ) 
Entire process is fast and easy 
6
7 
* Sources: GAO, CDC, OSHA, University of Virginia
Figure 4: Types of Parenteral Route 8
Dispersion Patterns: IM Injection 
Spherical bolus 
 lowest 
possible 
SA/V ratio 
 limited tissue 
disruption 
Amplified 
dispersion 
 medication 
forced at high 
speed through a 
tiny orifice 
 very high SA/V 
ratio 
 enhanced 
tissue disruption 
 Injection event 
lasts less than 
0.5 sec. 
9
BENEFITS OF NEEDLE-FREE INJECTIONS[2] 
 Eliminates needle phobia 
 Increased patient compliance 
 Higher dispersion pattern 
 Lower pain & stress 
 Targeted immune response (eg. Vaccine) 
 Faster injection time (0.5 sec.) 
10
APPLICATIONS 
1. Intramuscular, subcutaneous and intradermal administration 
11 
of Vaccines 
e.g. smallpox, polio, measles 
2. Intradermal administration of hormones 
e.g. growth hormone 
3. Intradermal administration of anesthetics 
e.g. Lidocaine 
4. Subcutaneous administration of insulin. 
5. Used in the treatment of migraine 
e.g. sumatriptan
It uses pressure from a 
spring loaded piston to 
create a fine stream of 
insulin through a small 
bore nozzle, delivering 
insulin to the subcutaneous 
layer. 
12 
Recojet is India’s first needle-free insulin delivery device.
DIFFERENT NEEDLE FREE INJECTORS 
AVAILABLE IN THE MARKET 
Technology/product name Company name Description 
Implaject Caretek Medical 
Simple, hand-held needle 
free injection device. Can be 
configured to be reusable 
with disposable cartridges.[3] 
Injex 30 Injex (HNS International) 
Spring-powered hand-held 
device with disposable 
ampoules that delivers 
0.05-1 ml. Focused on 
insulin delivery.[5] 
Intraject Weston Medical 
Applicable to drugs including 
proteins, peptides, 
monoclonal antibodies, small 
molecules and vaccines.[6] 
13
CURRENT TECHNOLOGIES 
Biojector-2000 
B-2000 Iject 
Vitajet 3
ONGOING CLINICAL RESEARCH 
 Currently, over 30 research collaborations 
NIH 
– HIV 
NCI 
– lymphoma 
MSK 
– melanoma 
USNMRC 
– malaria 
Pharmaceutical – Biotech – Academic Centers – Government
THE FUTURE 
16 
ID PEN™ 
Many of these needle-free alternative technologies are in the 
development stage. 
Inhalers are being improved as are nasal sprays, forced air 
injectors and patches. 
In the future, other foods may be genetically enhanced to deliver 
vaccines and other drugs. 
These include foods like bananas and tomatoes.
REFRENCES 
1. Vivek Ranjan Sinha, Aman Trehan, Pramil Tiwari:”Needle Free Injection 
Technology”:Express Healthcare Management (1st-15th July 2005) 
2. Henry, C. "Special Delivery." Chemical & Engineering News (September 
18, 2000): 49-65. 
3. Potera, C. "Making Needles Needless." Technology Review 
(September/October 1998): 67-70. 
4. Potera, C. "No-Needle Vaccine Techniques." Genetic Engineering News 
(August 1998): 19. 
5. http://bobbydyer.com/wp-content/ 
uploads/2011/01/Needleless%20injection%20thesis.pdf 
6. Mitragotri S. Current status and future prospects of needle-free liquid 
jet injectors. Nature Reviews Drug Discovery. July 2006; 5: 543-548. 
17

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Needle free injections rohit bharti

  • 1. Department Of Pharmaceutics Presented By : Guided By : Mr. Rohit U. Bharti Prof. R. S. Pentewar [HOD] ChannaBasweshwar Pharmacy College, Kava Road, Latur-413512. 1 07/02/2014 Needle free Injection : Designed for Confidence
  • 2. PRESENTATION OVERVIEW Introduction to Needle free injection State of the art technology Performance overview and past research Current applications  Products Available in Market Recent Technology and ongoing research References Questions 2
  • 3. WHAT IS IT ? 3 Needle-free injection systems are novel ways to introduce various medicines into patients without piercing the skin with a conventional needle. Needle-free injection techniques can be used to administer vaccines and medications in the pork industry. They are promoted as a possible option for patients with needle phobia
  • 5. 5
  • 6. Giving a Needle- free Injection[1]  Fill syringe with injectate Insert syringe into Biojector Hold at 90º with firm pressure at injection site Pull actuator, count to three, maintain pressure Remove device and hold pressure at site ( patient or parent can hold ) Entire process is fast and easy 6
  • 7. 7 * Sources: GAO, CDC, OSHA, University of Virginia
  • 8. Figure 4: Types of Parenteral Route 8
  • 9. Dispersion Patterns: IM Injection Spherical bolus  lowest possible SA/V ratio  limited tissue disruption Amplified dispersion  medication forced at high speed through a tiny orifice  very high SA/V ratio  enhanced tissue disruption  Injection event lasts less than 0.5 sec. 9
  • 10. BENEFITS OF NEEDLE-FREE INJECTIONS[2]  Eliminates needle phobia  Increased patient compliance  Higher dispersion pattern  Lower pain & stress  Targeted immune response (eg. Vaccine)  Faster injection time (0.5 sec.) 10
  • 11. APPLICATIONS 1. Intramuscular, subcutaneous and intradermal administration 11 of Vaccines e.g. smallpox, polio, measles 2. Intradermal administration of hormones e.g. growth hormone 3. Intradermal administration of anesthetics e.g. Lidocaine 4. Subcutaneous administration of insulin. 5. Used in the treatment of migraine e.g. sumatriptan
  • 12. It uses pressure from a spring loaded piston to create a fine stream of insulin through a small bore nozzle, delivering insulin to the subcutaneous layer. 12 Recojet is India’s first needle-free insulin delivery device.
  • 13. DIFFERENT NEEDLE FREE INJECTORS AVAILABLE IN THE MARKET Technology/product name Company name Description Implaject Caretek Medical Simple, hand-held needle free injection device. Can be configured to be reusable with disposable cartridges.[3] Injex 30 Injex (HNS International) Spring-powered hand-held device with disposable ampoules that delivers 0.05-1 ml. Focused on insulin delivery.[5] Intraject Weston Medical Applicable to drugs including proteins, peptides, monoclonal antibodies, small molecules and vaccines.[6] 13
  • 14. CURRENT TECHNOLOGIES Biojector-2000 B-2000 Iject Vitajet 3
  • 15. ONGOING CLINICAL RESEARCH  Currently, over 30 research collaborations NIH – HIV NCI – lymphoma MSK – melanoma USNMRC – malaria Pharmaceutical – Biotech – Academic Centers – Government
  • 16. THE FUTURE 16 ID PEN™ Many of these needle-free alternative technologies are in the development stage. Inhalers are being improved as are nasal sprays, forced air injectors and patches. In the future, other foods may be genetically enhanced to deliver vaccines and other drugs. These include foods like bananas and tomatoes.
  • 17. REFRENCES 1. Vivek Ranjan Sinha, Aman Trehan, Pramil Tiwari:”Needle Free Injection Technology”:Express Healthcare Management (1st-15th July 2005) 2. Henry, C. "Special Delivery." Chemical & Engineering News (September 18, 2000): 49-65. 3. Potera, C. "Making Needles Needless." Technology Review (September/October 1998): 67-70. 4. Potera, C. "No-Needle Vaccine Techniques." Genetic Engineering News (August 1998): 19. 5. http://bobbydyer.com/wp-content/ uploads/2011/01/Needleless%20injection%20thesis.pdf 6. Mitragotri S. Current status and future prospects of needle-free liquid jet injectors. Nature Reviews Drug Discovery. July 2006; 5: 543-548. 17