Needle free injection systems are innovative ways to introduce a variety of medicines in patients without piercing the skin with a traditional needle. These systems work by the mechanism in which liquid medication is forced at an elevated speed through a small orifice that is held against the skin. Due to this an ultrafine stream of high pressure fluid is created, that penetrates the skin devoid of the use of a needle, thus faster administration of drug occurs as compared to conventional needles. Needle free systems are designed to solve the problems created due to conventional needles making them safer, less expensive, and more suitable. It is expected that these systems will augment the rate of vaccination and reduce the amount of antibiotics prescribed. Moreover, they should decrease the occurrence of needle stick accidents that have been seen in some health care workers contracting diseases. Today, they are an increasingly rising technology that promises the administration of medicine efficient with reduction of pain. Companies are not only working on developing technologies that are safer and easier to use, but also on alternatives which can deliver more types of medicines.
UiPath Platform: The Backend Engine Powering Your Automation - Session 1
Needle free injections rohit bharti
1. Department Of Pharmaceutics
Presented By : Guided By :
Mr. Rohit U. Bharti Prof. R. S. Pentewar [HOD]
ChannaBasweshwar Pharmacy College, Kava Road, Latur-413512.
1
07/02/2014
Needle free Injection :
Designed for Confidence
2. PRESENTATION OVERVIEW
Introduction to Needle free injection
State of the art technology
Performance overview and past research
Current applications
Products Available in Market
Recent Technology and ongoing research
References
Questions
2
3. WHAT IS IT ?
3
Needle-free injection systems are novel ways to introduce various
medicines into patients without piercing the skin with a conventional
needle.
Needle-free injection techniques can be used to administer vaccines
and medications in the pork industry.
They are promoted as a possible option for patients with needle phobia
6. Giving a Needle- free Injection[1]
Fill syringe with injectate
Insert syringe into Biojector
Hold at 90º with firm pressure at injection site
Pull actuator, count to three, maintain pressure
Remove device and hold pressure at site
( patient or parent can hold )
Entire process is fast and easy
6
7. 7
* Sources: GAO, CDC, OSHA, University of Virginia
9. Dispersion Patterns: IM Injection
Spherical bolus
lowest
possible
SA/V ratio
limited tissue
disruption
Amplified
dispersion
medication
forced at high
speed through a
tiny orifice
very high SA/V
ratio
enhanced
tissue disruption
Injection event
lasts less than
0.5 sec.
9
11. APPLICATIONS
1. Intramuscular, subcutaneous and intradermal administration
11
of Vaccines
e.g. smallpox, polio, measles
2. Intradermal administration of hormones
e.g. growth hormone
3. Intradermal administration of anesthetics
e.g. Lidocaine
4. Subcutaneous administration of insulin.
5. Used in the treatment of migraine
e.g. sumatriptan
12. It uses pressure from a
spring loaded piston to
create a fine stream of
insulin through a small
bore nozzle, delivering
insulin to the subcutaneous
layer.
12
Recojet is India’s first needle-free insulin delivery device.
13. DIFFERENT NEEDLE FREE INJECTORS
AVAILABLE IN THE MARKET
Technology/product name Company name Description
Implaject Caretek Medical
Simple, hand-held needle
free injection device. Can be
configured to be reusable
with disposable cartridges.[3]
Injex 30 Injex (HNS International)
Spring-powered hand-held
device with disposable
ampoules that delivers
0.05-1 ml. Focused on
insulin delivery.[5]
Intraject Weston Medical
Applicable to drugs including
proteins, peptides,
monoclonal antibodies, small
molecules and vaccines.[6]
13
15. ONGOING CLINICAL RESEARCH
Currently, over 30 research collaborations
NIH
– HIV
NCI
– lymphoma
MSK
– melanoma
USNMRC
– malaria
Pharmaceutical – Biotech – Academic Centers – Government
16. THE FUTURE
16
ID PEN™
Many of these needle-free alternative technologies are in the
development stage.
Inhalers are being improved as are nasal sprays, forced air
injectors and patches.
In the future, other foods may be genetically enhanced to deliver
vaccines and other drugs.
These include foods like bananas and tomatoes.
17. REFRENCES
1. Vivek Ranjan Sinha, Aman Trehan, Pramil Tiwari:”Needle Free Injection
Technology”:Express Healthcare Management (1st-15th July 2005)
2. Henry, C. "Special Delivery." Chemical & Engineering News (September
18, 2000): 49-65.
3. Potera, C. "Making Needles Needless." Technology Review
(September/October 1998): 67-70.
4. Potera, C. "No-Needle Vaccine Techniques." Genetic Engineering News
(August 1998): 19.
5. http://bobbydyer.com/wp-content/
uploads/2011/01/Needleless%20injection%20thesis.pdf
6. Mitragotri S. Current status and future prospects of needle-free liquid
jet injectors. Nature Reviews Drug Discovery. July 2006; 5: 543-548.
17