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NAME : B.SENTHIL KUMAR
REG NO : 20BTBT043
SUBJECT: BIOCHEMISTRY
Introduction and Definition
 Principles of Drug Action
1. stimulation
2. depression
3. irritation
4. replacement
5. cytot...
DRUG
POWER
?
Physiological and biochemical
effects of drugs and their MOA at
organ system, subcellular and
macro molecular level
What the drug do
How the drug do
Action – effect sequence
Dose – effect relationship
CLASSIFIED AS:
1. stimulation
2. depression
3. irritation
4. replacement
5. cytotoxic action
Drug selectively enhance the level of activity of specialized
cells
Eg.
Adrenaline HEART
Pilocarpine SALIVARY GLANDS
Drug selectively depress activity of specialized cells.
Eg.
Barbiturates CNS
LA Nerve conduction
Drug creates selective noxious
effect on less specialized cells
 MILD :-
1.stimulate function
 STRONG :-
1. Inflammation
2. Necrosis
3. Corrosion
4. Damage
Use of natural metabolites and hormones in
deficiency states.
Eg.
Levodopa Parkinsonism
Insulin DM
Iron Anemia
ENZYME
ION CHANNELS
TRANSPORTERS
RECEPTORS
- VERY IMPORTANT
- ALL BIOLOGICAL REACTIONS
enzymatic activity
ENZYME
STIMULATION
Natural Metabolites
Receptors
and
Secondary Messengers
ENZYMATIC REACTIONS
Enzyme
Induction
Enzyme
Inhibition
COMPETITIVE NON COMPETITVE
Drug Substrate
Enzyme
X X X
KM : increased
Vmax : unchanged
Substrate displaces DRUG
Maximum reaction of velocity attained
 Eg 1:
physostigmine
neostigmine
acetylcholine cholinesterase
Eg 2:
sulfanomide PABA Bacterial folate synthesis
Drug Substrate
X X X
enzyme
Methotrecate > DHFA
5000 times
Dihydrofolate reductase
Km
Vmax
ENZYME
Lose property
CS AS
KM : unchanged
Vmax : reduced
Eg :
LA obstruct Na+ channels ,
Nifedipine block Ca+ channels
Nicorandil opens K+ channels
Desipramine NET
neural uptake of
noradrenaline
Fluoxetine neuronal
5HT
transporter
Macromolecule / binding site
Located on surface /within effector cells
Serves to recognizes the signal molecules
Initi...
Pharmacodynamics OR Pharmacology
Pharmacodynamics OR Pharmacology
Pharmacodynamics OR Pharmacology
Pharmacodynamics OR Pharmacology
Pharmacodynamics OR Pharmacology
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Pharmacodynamics OR Pharmacology

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it can be prepared by student (B.Tech Biotechnology, 2nd year, KAHE). If u have any doubts pls clear with this YOUTUBE

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Pharmacodynamics OR Pharmacology

  1. 1. NAME : B.SENTHIL KUMAR REG NO : 20BTBT043 SUBJECT: BIOCHEMISTRY
  2. 2. Introduction and Definition  Principles of Drug Action 1. stimulation 2. depression 3. irritation 4. replacement 5. cytotoxic action  Mechanism of Drug Action 1. enzyme 2. ion channels 3. transporters 4. receptors
  3. 3. DRUG POWER
  4. 4. ?
  5. 5. Physiological and biochemical effects of drugs and their MOA at organ system, subcellular and macro molecular level
  6. 6. What the drug do How the drug do Action – effect sequence Dose – effect relationship
  7. 7. CLASSIFIED AS: 1. stimulation 2. depression 3. irritation 4. replacement 5. cytotoxic action
  8. 8. Drug selectively enhance the level of activity of specialized cells Eg. Adrenaline HEART Pilocarpine SALIVARY GLANDS
  9. 9. Drug selectively depress activity of specialized cells. Eg. Barbiturates CNS LA Nerve conduction
  10. 10. Drug creates selective noxious effect on less specialized cells
  11. 11.  MILD :- 1.stimulate function  STRONG :- 1. Inflammation 2. Necrosis 3. Corrosion 4. Damage
  12. 12. Use of natural metabolites and hormones in deficiency states. Eg. Levodopa Parkinsonism Insulin DM Iron Anemia
  13. 13. ENZYME ION CHANNELS TRANSPORTERS RECEPTORS
  14. 14. - VERY IMPORTANT - ALL BIOLOGICAL REACTIONS
  15. 15. enzymatic activity ENZYME STIMULATION Natural Metabolites Receptors and Secondary Messengers
  16. 16. ENZYMATIC REACTIONS Enzyme Induction Enzyme Inhibition
  17. 17. COMPETITIVE NON COMPETITVE
  18. 18. Drug Substrate Enzyme X X X
  19. 19. KM : increased Vmax : unchanged Substrate displaces DRUG Maximum reaction of velocity attained
  20. 20.  Eg 1: physostigmine neostigmine acetylcholine cholinesterase Eg 2: sulfanomide PABA Bacterial folate synthesis
  21. 21. Drug Substrate X X X enzyme
  22. 22. Methotrecate > DHFA 5000 times Dihydrofolate reductase Km Vmax
  23. 23. ENZYME Lose property CS AS KM : unchanged Vmax : reduced
  24. 24. Eg : LA obstruct Na+ channels , Nifedipine block Ca+ channels Nicorandil opens K+ channels
  25. 25. Desipramine NET neural uptake of noradrenaline Fluoxetine neuronal 5HT transporter
  26. 26. Macromolecule / binding site Located on surface /within effector cells Serves to recognizes the signal molecules Initiate response to it But itself has no other functions

it can be prepared by student (B.Tech Biotechnology, 2nd year, KAHE). If u have any doubts pls clear with this YOUTUBE

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