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만성신부전증 환자의 투석효율성을
높이기 위한 연구계획서
박현우
Hypotension is a big problem!
• Hypotension during dialysis treatment is an unresolved
issue.
• Delivery of an adequate do...
IDH (Intradialytic Hypotension)
• Definition
: A fall in SBP by at least 20mmHg or SBP < 100mmHG

•
:
:
:
:
:
:
:
:
:
:
:
...
Intradialytic Hypotension (IDH)
mechanism?
Patient factors

 Cardiac disease
- Systolic dysfunction
- Diastolic dysfuncti...
IDH ---> Hypertension
• Mechanism of therapy for intradialytic hypotension are
of great interest (van der Zee. S et al.)
•...
Solution?
Routine management
of IDH

 Target dry weight
 Diet fluid counseling
 Medication adjustment
 Correct anemia
...
How to increase BP?
Farese S. et al. Am J Kidney Dis. 2008.
•

TEMS : Transcutaneous muscle simulation , PCMs : Passive cy...
Patient Characteristics
TEMS & PCMs during dialysis show
significant results in raising BP
Increased Cardiac Output!
• Heart rate was unchanged during both treatment (TEMS &
PCM) modalities.
• Therefore, the obser...
Efficiency? Urea & Phosphate!

• Longer observation periods with more patients are needed to
assess potential benefits of ...
Several Studies about Passive Training
• Passive movement of the lower leg has been found to result in an
approximate thre...
Capillarization and presence of proliferating endothelial cells in
skeletal muscle before and after passive training of th...
Relationship with CVD ?
• Farese et al. (Am J Kidney Dis)
: Blood flow in the Femoral Artery increased up to 40% with TEMS...
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Intradialytic hypotension [투석 중 저혈압]

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본국에서 진행될 새로운 연구계획서

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Intradialytic hypotension [투석 중 저혈압]

  1. 1. 만성신부전증 환자의 투석효율성을 높이기 위한 연구계획서 박현우
  2. 2. Hypotension is a big problem! • Hypotension during dialysis treatment is an unresolved issue. • Delivery of an adequate dose of dialysis is essential to improve the prognosis of dialysis patients • Low blood pressure during the hemodialysis procedure is expected to occur more frequently in patients with comorbidities because it compels a limit to dialysis time and dialysis efficacy. - van der Zee S, Thompson A, Zimmerman R, et al: Vasopressin administration facilitates fluid removal during hemodialysis. - Davenport A: Intradialytic complications during hemodialysis. - Imai E, Fujii M, KohnoY, et al: Adenosine A1 receptor antagonist improves intradialytic hypotension.
  3. 3. IDH (Intradialytic Hypotension) • Definition : A fall in SBP by at least 20mmHg or SBP < 100mmHG • : : : : : : : : : : : : : : : Cause Decline Cardiac Function and Systemic Vascular Resistance (SVR) during removed solute A rapid reduction in Plasma osmolality High Interdialytic weight gain Anemia Autonomic neuropathy Decrease pressor response to Vasopressor agents LV Hypertrophy & Decrease cardiac preload Decrease cardiac reserve Increase arterial stiffness Impaired venous compliance Meal Use of low sodium/ Increase magnesium dialysate Anti-hypertension medication before HD Excessive release of vasodilators (Not Adrenomedullin and Adenosine) Imbalance in the synthesis of vasoconstrictors (Endothelin & Vasopressin)
  4. 4. Intradialytic Hypotension (IDH) mechanism? Patient factors  Cardiac disease - Systolic dysfunction - Diastolic dysfunction  Arrhythmias  Pericardial disease  Autonomic neuropathy  Dietary excess  Interdialytic weight gain  Food ingestion in dialysis  Antihypertensive agents  Anemia (< Hb 7.0g/dL) Dialysis procedure factors  Ultrafiltration, solute removal  Thermal amplication  Sympathetic failure - Increased adenosine - Increased nitric oxide  Dialysate composition  Low sodium (<138mEq/L)  Low calcium  High magnesium  Acetate
  5. 5. IDH ---> Hypertension • Mechanism of therapy for intradialytic hypotension are of great interest (van der Zee. S et al.) • Increase in adenosine generation during hemodialysis may cause vasodilation and decrease in cardiac output, which results in systemic hypotension (Imai. E et al.) • Removal of excess extracellular fluid -> symptomatic decreases in arterial pressure -> intradialytic hypotension -> chronically volume-expanded -> Chronic Hypertension (van der Zee. S et al.)
  6. 6. Solution? Routine management of IDH  Target dry weight  Diet fluid counseling  Medication adjustment  Correct anemia  High sodium dialysate  Sodium modeling Individualized therapy of IDH  High calcium dialysate  Low-magenesium dialysate  Carnitine  Sertraline  Cool dialysate  Midodrine (A vasopressor / antihypotensive agent)
  7. 7. How to increase BP? Farese S. et al. Am J Kidney Dis. 2008. • TEMS : Transcutaneous muscle simulation , PCMs : Passive cycling movement • For each patient, each procedure was performed only once weekly and never on the same weekday.
  8. 8. Patient Characteristics
  9. 9. TEMS & PCMs during dialysis show significant results in raising BP
  10. 10. Increased Cardiac Output! • Heart rate was unchanged during both treatment (TEMS & PCM) modalities. • Therefore, the observed increase in blood pressure can only be explained by an increase in either peripheral resistance or cardiac output. • For TEMS and active exercise, decreased vascular resistance has been described. Miller BF et al. Phys Ther 80:53-60, 2000 • Thus, increased cardiac output is a more likely explanation for the increase in blood pressure, a contention supported because increased central blood and preload volume positively alter cardiac output. Hanft LM et al. Cardiovasc Res 77:627-636, 2008 • There is an evidence that electrical muscle stimulation increases venous backflow from the musculature. Clarke Moloney M et al. Eur J Vasc Endovasc Surg 31:300-305, 2006
  11. 11. Efficiency? Urea & Phosphate! • Longer observation periods with more patients are needed to assess potential benefits of TEMS and PCMs on hypotensive episodes during dialysis sessions
  12. 12. Several Studies about Passive Training • Passive movement of the lower leg has been found to result in an approximate three-fold increase in muscle blood flow, and stretch of the muscle tissue without an alteration in either EMG activity or muscle oxygen uptake. (Krustrup et al. 2004) • Vascular endothelial growth factor (VEGF) is probably one of the most important factor for endothelial activation, proliferation and migration. • The passive movement model induced an enhanced level of muscle interstitial VEGF protein and an increased endothelial cell proliferative effect of muscle interstitial fluid from the muscle as well as a higher expression of endothelial nitric oxide synthase (eNOS) mRNA in the muscle. (Hellsten et al. 2008, Am J Physiol Regul Integr Comp Physiol)
  13. 13. Capillarization and presence of proliferating endothelial cells in skeletal muscle before and after passive training of the leg • B. Hoier et al. J Physiol 588.19 (2010) pp 3833–3845
  14. 14. Relationship with CVD ? • Farese et al. (Am J Kidney Dis) : Blood flow in the Femoral Artery increased up to 40% with TEMS and PCMs (unpublished) : Increased Cardiac Output by electrical muscle stimulation increases venous backflow from the musculature (Increased venous return) • Future direction : ABI (Ankle Brachial Index) : BP Function between Ankle and Brachial : FMD : specific to Femoral Arterial function : Heart Rate Variability : Autonomic dysfunction : Cardiac Function : Mitral Inflow Conventional Doppler, Mitral Annular Velocity Tissue Doppler
  15. 15. Thank you

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