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Diabetes Insipidus - Endocrinology MRCP 1 - 123Doc Education


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Introduction to Diabetes Insipidus, as part of the Endocrinology MRCP 1 course. These are slideshows only. The demonstration with video presentation and explanation that goes along with these slides, as well as free example exam questions and the paid full e-lecture can be viewed at

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Diabetes Insipidus - Endocrinology MRCP 1 - 123Doc Education

  1. 1. Endocrinology MRCP 1Diabetes InsipidusDemonstration
  2. 2. Diabetes Insipidus• Definition: Large volume (>3l/24hrs) of diluteurine (<300 mOsmol/kg)Types: Cranial and Nephrogenic
  3. 3. Cranial• Lack of presence or ability to posteriorpituitary to secrete ADHFamilial: Autosomal dominant (vasopressingene)
  4. 4. Nephrogenic• Lack of ADH action on kidneyFamilial: X-linked recessive (V2 receptormutations) andAutosomal recessive (AQP-2 mutations)
  5. 5. Causes• Cranial: Head trauma, CNS tumours,neurosurgery, pituitory/hypoth. disease,granulomatous disease e.g. neurosarcoid, TB,lymphocytic hypophysitis• Nephrogenic: Drugs e.g. Lithium,demeclocycline, hypercalcaemia,hypokalaemia, hyperglycaemia, chronic renalfailure
  6. 6. Treatments• Cranial: Tx Desmopressin – acts on V2receptors of kidney• Nephrogenic: Tx High dosedesmopressin/thiazide diuretics/NSAID e.g.indomethican• Side Effects: Fluid retention/hyponatraemia
  7. 7. Water deprivation test• Urine concentration following waterdeprivation test (mmol/L)
  8. 8. More• For the corresponding video lecture presentedby Dr Andrew Solomon, free example examquestions and access to the full eLectureplease