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Publications

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Publications

  1. 1. MICHAEL REUMAN, Ph.D. PUBLICATIONS: M. Reuman, S. Beish, J. Davis, M. J. Batchelor, M. C. Hutchings, D. F. C. Moffat, P. J. Connolly, and R. K. Russell “Scalable Synthesis of the VEGF-R2 Kinase Inhibitor JNJ-17029259 Using Ultrasound-Mediated Addition of MeLi-CeCl3 to a Nitrile” J. Org. Chem., 2008, 73, 1121. M. Reuman, Z. Hu, G.-H. Kuo, X. Li, R. K. Russell, L. Shen, S. Youells, and Y. Zhang “Synthesis of a 5-((Aryloxy)methyl)-3-(4-(trifluoromethyl)phenyl)[1,2,4]thiadiazole Derivative: A Promising PPARα,δ Agonist” Organic Process Research & Development, 2007, 11, 1010. L. Shen, Y. Zhang, A. Wang, E. Sieber-McMaster, X. Chen, P. Pelton, J. Z. Xu, M. Yang, P. Zhu, L. Zhou, M. Reuman, Z. Hu, R. Russell, A. C. Gibbs, H. Ross, K. Demarest, W. V. Murray, and G.-H. Kuo “Synthesis and identification of [1,2,4]thiadiazole-derivatives as a new series of potent and orally active peroxisome proliferators-activated receptors  and  dual agonists” J. Med. Chem., 2007, 50, 3954. X. Li, M. Reuman, R. K. Russell, S. Youells, S. Beish, Z. Hu, S. Branum, N. Jain, Z. Sui “Synthesis of Tetracyclic Heterocompounds as Selective Estrogen Receptor Modulators. Part 2. Process Improvement for Scale-Up Of 2,5,8-Substituted 11,12-Dihydro-5H-6,13-dioxabenzo- [3,4]cyclohepta[1,2-a]naphthalene Derivatives” Organic Process Research & Development, 2007, 11, 731. T. V. Hughes, S. L. Emanuel, A. K. Beck, S. K. Wetter, P. J. Connolly, K. Prabha, M. Reuman, J. Seraj, A. R. Fuentes-Pesquera, R. H. Gruninger, S. A. Middleton, R. Lin, J. M. Davis, and D. F. C. Moffat “4-Aryl-5-cyano-2-aminopyrimidines as VEGF-R2 inhibitors: Synthesis and biological evaluation” Bioorg. Med. Chem. Lett., 2007, 17, 3266. X. Li, M. Reuman, R. K. Russell, R. Adams, R. Ma, S. Beish, S. Branum, S. Youells, N. Jain, R. Kanojia, and Z. Sui “Synthesis of Tetracyclic Heterocompounds as Selective Estrogen Receptor Modulators. Part 1. Process Development for Scale-up of 2,5,8-Substituted 5,11-Dihydro chromeno[4,3-c]chromene Derivatives” Organic Process Research & Development, 2007, 11, 414. X. Li, M. Reuman, and R. K. Russell “Direct Conversion of Substituted Pyrrole-2-Carboxylic Acid Methyl Esters to their 2-Carbonitrile Analogs” Heterocycles, 2006, 70, 201. J. Bullington, D. Argentieri, K. Averill, D. Carter, D. Cavender, B. Fahmy, X. Fan, D. Hall, G. Heintzelman, P. Jackson, W.-P. Leung, X. Li, P. Ling, G. Olini, T. Razler, M. Reuman, K. Rupert, R. Russell, J. Siekierka, S. Wadsworth, R. Wolff, B. Xiang, and Y.-M. Zhang “Inhibitors of Unactivated p38 MAP Kinase” Bioorg. Med. Chem. Lett., 2006, 16, 6102 N. Chen, N. Jain, J. Xu, M. Reuman, X. Li, R. K. Russell, and Z. Sui, “Synthesis of Novel Tetracyclic Chromenes through Carbanion Chemistry of 4-Methyl Coumarins” Tetrahedron Lett., 2006, 47, 5909. S. Emanuel, R. H. Gruninger, A. Fuentes-Pesquera, P. J. Connolly, J. A. Seamon, S. Hazel, R. Tominovich, B. Hollister, C. Napier, M. R. D’Andrea, M. Reuman, G. Bignan, R. Tuman, D. Johnson, D. Moffat, M. Batchelor, A. Foley, J. O’Connell, R. Allen, M. Perry, L. Jolliffe, and S. A. Middleton “A Vascular Endothelial Growth Factor Receptor-2 Kinase Inhibitor Potentiates the Activity of the Conventional Chemotherapeutic Agents Paclitaxel and Doxorubicin in Tumor Xenograft Models” Mol. Pharmacol., 2004, 66, 635.
  2. 2. MICHAEL REUMAN, Ph.D. M. Reuman, S. J. Daum, B. Singh, M. P. Wentland, R. B. Perni, P. Pennock, P. M. Carabateas, M. D. Gruett, M. T. Saindane, P. H. Dorff, S. A. Coughlin, D. M. Sedlock, J. B. Rake, and G. Y. Lesher, "Synthesis and Antibacterial Activity of some Novel 1-Substituted 1,4-Dihydro-4-oxo-7-pyridinyl-3-quinolinecarboxylic Acids. Potent Antistaphylococcal Agents" J. Med. Chem.,1995, 38, 2531. G. D. Diana, P. Rudewicz, D. C. Pevear, T. J. Nitz, S. C. Aldous, D. J. Aldous, D. T. Robinson, T. Draper, F. J. Dutko, C. Aldi, G. Gendron, R. C. Oglesby, D. L. Volkots, M. Reuman, T. R. Bailey, R. Czerniak, T. Block, R. Roland, and J. Oppermann, "Picornavirus Inhibitors: Trifluoromethyl Substitution Provides a Global Protective Effect against Hepatic Metabolism" J. Med. Chem., 1995, 38, 1355. M. Reuman, J. P. Mallamo, and D. L. DeHaven-Hudkins, "Synthesis and Binding Affinity of 2,3,3a,4,9,9a-Hexahydro-9,4-(Iminomethano)-1H-benz[f]indenes. Ligands for the PCP Site of the NMDA Receptor" Bioorg. Med. Chem. Lett., 1995, 5, 371. M. Reuman, M. A. Eissenstat, and J. D. Weaver III, "Cyanide Mediated Decarboxylation of 1-Substituted-4-oxoquinoline and 4-oxo-1,8-naphthyridine-3-carboxylic Acids" Tetrahedron Lett., 1994, 35, 8303. B. Singh, E. R. Bacon, S. Robinson, R. K. Fritz, G. Y. Lesher, V. Kumar, J. A. Dority, M. Reuman, G.-H. Kuo, M. A. Eissenstat, E. D. Pagani, D. C. Bode, R. G. Bently, M. J. Connell, L.T. Hamel, and P. J. Silver, "Novel cAMP PDE III Inhibitors: Imidazo[4,5-b]pyridin-2(3H)-ones and Thiazolo[4,5-b]pyridin-2(3H)-ones and Their Analogs" J. Med. Chem., 1994, 37, 248. M. P. Wentland, G. Y. Lesher, M. Reuman, M. D. Gruett, B. Singh, S. C. Aldous, P. H. Dorff, J. B. Rake, and S. A. Coughlin, "Mammalian Topoisomerase II Inhibitory Activity of 1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quinolinecarboxylic Acid and Related Derivatives" J. Med. Chem., 1993, 36, 2801. M. P. Wentland, G. Y. Lesher, M. Reuman, G. M. Pilling, M. T. Saindane, R. B. Perni, M. A. Eissenstat, J. D. Weaver III, B. Singh, J. Rake, and S. A. Coughlin, "Relationship of Structure of Bridged (2,6-Dimethyl-4-Pyridinyl) Quinolones to Mammalian Topoisomerase II Inhibition" Bioorg. Med. Chem. Lett., 1993, 3, 1711. M. Reuman and G. Y. Lesher, "Antibacterial Agents, Synthetic-Quinolones" in the Kirk-Othmer: Encyclopedia of Chemical Technology 4th Edition, J. I. Kroschwitz, Ed., John Wiley: NY, 1992, 854. M. Reuman and A. I. Meyers, "The Synthetic Utility of Oxazolines in Aromatic Substitution" Tetrahedron, 1985, 41, 837. A. I. Meyers, R. J. Himmelsbach, and M. Reuman, "The Reductive Cleavage of Aryl Oxazolines to Benzaldehydes and Substituted Toluenes" J. Org. Chem., 1983, 48, 4053. A. I. Meyers, M. Reuman, and R. A. Gabel, "Nucleophilic Annulations of Aromatics. Novel Route to Benzo-Fused Ring Systems via Oxazoline Activation" J. Org. Chem., 1981, 46, 783. D. Masilamani, M. E. Reuman, and M. Rogic, "Ene-Type Reaction through the Intermediacy of the 1,4-Dipolar Ion in the Reaction of Tetracyanoethylene with Nucleophilic Double Bonds in Liquid Sulfur Dioxide" J. Org. Chem., 1981, 46, 4602.
  3. 3. MICHAEL REUMAN, Ph.D. L. K. Truesdale and M. E. Reuman, "Sodium Bismuthate Oxidation of Olefins" J. Org. Chem., 1980, 45, 726. PATENTS: M, Reuman “Process for the Preparation of Tri-Substituted Pyridine and Tri-Substituted Pyrimidine Derivatives useful as GDIR Agonists” US 20100113480 A1 May 2010. A. Choudhury and M. Reuman “Process for the Preparation of Tri-Substituted Pyridine and Tri-Substituted Pyrimidine Derivatives useful as GDIR Agonists” US 20100113479 A1 May 2010. M. Reuman, R. Faessler, A. Roessler, K. Sorgi, X. Li, and J. Grimm “One-Pot Condensation-Reduction Methods for Preparing Substituted Allylic Alcohols” US 20080009628 A1 Jan 2008, WO 2008005670 A2 Jan 2008 D. J. Aldous, T. R. Bailey, G. D. Diana, G.-H. Kuo, T. J. Nitz, and M. Reuman, "Substituted Quinoline Derivatives Useful as Antipiconaviral Agents" US 5,523,312, June 1996, US 5,514,692, May 1996, WO1996009822 A1 April 1996. G. Y. Lesher, B. Singh, M. Reuman, and S. J. Daum, "Pyridinyl-Quinoline Compounds, their Preparation and Use", US 5,169,853, December 1992. European Patent EP 417,669 A2, March 1991 G. Y. Lesher, B. Singh, and M. Reuman, "Pyridinyl-Quinoline Compounds, their Preparation and Use", US 5,075,319, December 1991. G. Y. Lesher, B. Singh, and M. Reuman, "4-Oxo-3-quinolinecarboxylic acids Useful as Antibacterial Agents and Preparation thereof", EP 309,789, April 1989. PRESENTATIONS: Z. Hu, U. Maharoof, J. Travins, M. Reuman, R. Russell, and R. Galemmo “Improved Synthesis of Indane-Fused Pyrazole Compound: An Anti-Proliferative Agent for the Treatment of Solid Tumors” 40th National Organic Chemistry Symposium, Duke University, Durham, NC, May 2007 M. Reuman, J. P. Mallamo, W. G. Earley, and D. L. DeHaven-Hudkins "Synthesis and Binding Affinity of 2,3,3a,4,9,9a-Hexahydro-9,4-(Iminomethano)-1H-benz[f]indenes. Ligands for the PCP Site of the NMDA Receptor" Winter Conference on Bioorganic and Medicinal Chemistry, January 1995, Steamboat Springs, CO. M. Reuman, M. Eissenstat, and J. Weaver "Cyanide Mediated Decarboxylation of Substituted 4-Oxo-3-quinolinecarboxylic acids" Gordon Research Conference on Organic Reactions and Processes, July 1992. M. P. Wentland, G. Y. Lesher, M. Reuman, M. D. Gruett, B. Singh, S. C. Aldous, P. H. Dorff, J. B. Rake, and S. A. Coughlin, "Relationship of Mammalian Topoisomerase II Inhibitory Potency to the structure of 6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid derivatives", Proc. Am. Assoc. Cancer Res., March 1992, Abstract No. 2577, 431. S. A. Coughlin, D. W. Danz, R. G. Robinson, K. M. Klingbell, M. P. Wentland, G. Y. Lesher, M. Reuman, and J. B. Rake, "Dramatic Divergence in Structure Activity Requirement for Topoisomerase II Inhibition by Quinolones", Proc. Am. Assoc. Cancer Res., March 1992, Abstract No. 2576, 431.
  4. 4. MICHAEL REUMAN, Ph.D. M. P. Wentland, G. Y. Lesher, M. Reuman, G. M. Pilling, M. T. Saindane, R. B. Perni, M. A. Eissenstat, J. D. Weaver, J. B. Rake, and S. A. Coughlin, "Mammalian Topoisomerase Inhibitory Activity of 1,8-bridged-7-(2,6-dimethyl(4-pyridinyl))-3-quinolinecarboxylic acids", Proc. Am. Assoc. Cancer Res., May 1991, Abstract No. 14317, 336. D. M. Deuel, D. M. Sedlock, G. Y. Lesher, S. J. Daum, M. P. Wentland, M. Reuman, M. A. McKinlay, and J. B. Rake, "In Vitro Antibacterial Activity of a New Dimethylpyridinyl Quinolone, Win 57273, against Clinical Pathogens", 29th Interscience Conference on Antimicrobial Agents and Chemotherapy; Houston, TX, September, 1989, No. 1194. M. Reuman, S. J. Daum, B. Singh, S. A. Coughlin, D. M. Sedlock, J. B. Rake, and G. Y. Lesher, "Synthesis and Antibacterial Activity of Some Novel 1-Substituted 7-Pyridinyl-1,4-Dihydro-4-Oxoquinoline-3-Carboxylic Acids", 29th Interscience Conference on Antimicrobial Agents and Chemotherapy; Houston, TX, September, 1989, No. 1193.

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