Slides of benign epithelium t.

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Slides of benign epithelium t.

  1. 1. NEOPLASIAUncontrolled uncoordinated cell division non responsive.to growth controls
  2. 2. :Benign Malignant Well circumscribed,  Not well cirumscribed, Usually small in size,  Usually larger in size, Slow growing,  Fast growing, capsulated,  non capsulated, Non-invasive  Invasive & Infiltrate No hge. and necrosis  He and necrosis. do not metastasize,  Metastasize. well differentiated,  poorly differentiated, suffix “oma” eg.  Suffix “Carcinoma” or Fibroma. “Sarcoma”
  3. 3. Signs of malignancyCellular Nuclear Dysplasia (different from tissue of origin)  Large nuclei Disorganization  Hyperchromasia. Loss of polarity.  N/C ratio high. Pleomorphism  Pleomorphic nuclei. (variable in size and  Prominent nucleoli. shape)  Frequent mitoses. Loss of cohesion.  Abnormal mitotic Presence of giant figures. cells
  4. 4. Tumor Diagnosis History and Clinical examination Imaging - X-Ray, US, CT, MRI Biopsy – – Conventional histopathology: Paraffin sections stained with ordinary stains – Frozen sections: Intra-operativeexamination of frozen tissue sections. – Immunohistochemistry: Paraffin or frozen sections stained for markers. Cytology – – Exfoliative cytology : study of cells shedded in body fluids. – FNAB: Aspiration of cells from tumor masses. Tumor markers: Blood laboratory analysis Molecular Tech (DNA studies) – Gene re-arrangement studies ( in lymphoma) – DNA quantitation by image analaysis or flow cytometry.
  5. 5. Benign Malignant
  6. 6. Slides of the weekBenign Epithelial Tumours Squamous cell papilloma. Adenoma intestine. Pericanalicular fibroadenoma. Intracanalicular fibroadenoma.
  7. 7. Papilloma Squamous cell papilloma(1).skinColumnar cell papilloma(2)as :Duct papilloma of breast
  8. 8. Squamous cell Papilloma.Benign tumors of surface epithelium :Grossly Non capsulated, projectingvillous-like from.the surface, sessile or pedunculated:Microsciopically Vascularized connective tissue core.covered with proliferating epithelium . [-
  9. 9. Squamous cell papilloma
  10. 10. Squamous cell papilloma
  11. 11. Squamous cell papilloma
  12. 12. Squamous cell papilloma
  13. 13. Squamous cell papilloma
  14. 14. Duct Papilloma, Breast
  15. 15. Adenoma.Benign tumor arising from columnar epitheliumGrossly: Capsulated, round or oval mass with a.solid or cystic cut section:Histological types.: proliferating acini with stromaSimple adenoma(1): proliferating acini+Fibroadenoma(2) proliferatingstroma.( (Breast: proliferating acini with dilatedCystadenoma(3) acini forming cysts.((Ovary: cystadenoma withPapillary cystadenoma(4) the epithelial lining forming.papillae
  16. 16. Adenoma of intestine Benign tumour formed of  1-proliferating intestinal mucosal glands lined with columnar epithelial cells and slightly variable in size 2- Glands separated by vascularized connective tissue stroma.
  17. 17. Adenomatous polyp - Colon
  18. 18. Familial Adenomatous Polyposis
  19. 19. Intestinal adenoma,Villous type
  20. 20. Adenoma
  21. 21. Adenoma
  22. 22. Fibroadenoma of the breast* Mixed Tumour formed of  epithelial and stromalelements•Most common breast tumor in adolescent and young adultwomen (peak age = third decade).• Higher incidence in black patients• Well-circumscribed, freely movable (Breast mouse), nonpainful mass• Regress with age if left untreated (hormonal-dependent T).•2 Types :1- intracanalicular pattern. Compressed ducts2-pericanalicular growth . Opened ducts .
  23. 23. Breast Fibroadenoma
  24. 24. Pericanalicular fibroadenomaTumor is capsulatedTumor consists of:1-  Opened proliferating breast ducts  lined with an inner columnar and outer myoepithelial cells.2- Ducts are separated by loose myxoid connective tissue stroma.
  25. 25. Pericanalicular fibroadenoma
  26. 26. Intracanalicular fibroadenoma* Tumor is capsulated• Tumor consists of • 1- Compressed proliferating breast ducts that are lined with an inner columnar and outer myoepithelial cells.• 2- Ducts are separated by  loose myxoid connective tissue stroma.
  27. 27. Intracanalicular Fibroadenoma

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