1
OBJECTIVES:
At the end of this lecture, students will be able to:
a) review disease process of Diabetes mellitus
b) discus...
DIABETES MELLITUS
 Disorder

of carbohydrate, fat and protein
metabolism caused by lack or inefficient
use of insulin in ...
Disease process of Diabetes mellitus

4
INSULIN
 Sources

of insulin:

 Bovine insulin
 Porcine insulin
 Human insulin


Uses

 Pharmacokinetics:

 Injecte...
Insulin preparations


Insulin preparations differ with respect to their:
 Source
 Strength
 Formulation




Dose: 0...
ORAL HYPOGLYCEMIC AGENTS:
Sulphonylureas:
Example: Glibenclamide
Gliclazide
Glipizide
Glimepride

1.

2. Biguanide:
Exampl...
ORAL HYPOGLYCEMIC AGENTS:
Thiazolidinediones:
Example: Pioglitazone
Rosiglitazone

3.

Meglitinide:
Example: Repaglinide
N...
Nursing process
 Assessment,

Potential nursing diagnosis

 Planning
 Implementation
 Evaluation

9
Nursing process
 Assessment,

Potential nursing diagnosis

 Planning
 Implementation
 Evaluation

9
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Anti diabetic drugs

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Anti diabetic drugs

  1. 1. 1
  2. 2. OBJECTIVES: At the end of this lecture, students will be able to: a) review disease process of Diabetes mellitus b) discuss the role of insulin in metabolic process c) discuss different types of anti-diabetic agents with their mode of action, side effects and care d) list the principles of therapy for all anti-diabetic agents e) state the reasons for combinations of insuli and oral hypoglycemic agents. 2
  3. 3. DIABETES MELLITUS  Disorder of carbohydrate, fat and protein metabolism caused by lack or inefficient use of insulin in the body.  Diabetes is classified as:  Type –I (IDDM)  Type – II (NIDDM) 3
  4. 4. Disease process of Diabetes mellitus 4
  5. 5. INSULIN  Sources of insulin:  Bovine insulin  Porcine insulin  Human insulin  Uses  Pharmacokinetics:  Injected as SC, IM, IV  Peak plasma concentration attain in 6090min. 5
  6. 6. Insulin preparations  Insulin preparations differ with respect to their:  Source  Strength  Formulation   Dose: 0.3units/kg (16 – 20units daily) Adverse effects of insulin:  Hypoglycemia  Lipodystrophy  Allergic reactions 6
  7. 7. ORAL HYPOGLYCEMIC AGENTS: Sulphonylureas: Example: Glibenclamide Gliclazide Glipizide Glimepride 1. 2. Biguanide: Example: Metformin 7
  8. 8. ORAL HYPOGLYCEMIC AGENTS: Thiazolidinediones: Example: Pioglitazone Rosiglitazone 3. Meglitinide: Example: Repaglinide Netaglinide 4. 5. Alpha- glucidose inhibitors: Example: Acarbose 8
  9. 9. Nursing process  Assessment, Potential nursing diagnosis  Planning  Implementation  Evaluation 9
  10. 10. Nursing process  Assessment, Potential nursing diagnosis  Planning  Implementation  Evaluation 9

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