Embriology                                                                                                                ...
3wk                               13~14
                                3                                     primitive st...
ventricle

                                                                                    primordial Atrium          ...
>         primordial pharynx>                                                                              &            -
...
1.decidua parietalis
                                                               2.        capsularis
                 ...
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Embryology 胚胎學

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Embryology summary

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Embryology 胚胎學

  1. 1. Embriology CMU M44 Zack.lim Primordial follicle 1)primary oocyte 1st mitosis 2)follicular epithelial cells - Primary follicle Secondary follicle 2nd mitosis 1st mitosis metaphase 1) follicle a)2ndary oocyte mitosis a)zygote b)1st polar body b)2nd polar body 2) antrum epididymis -storage of sperm vas deference- Seminal vesical - semen,MIF(mullerian inhibitory factor) efferent duct- 3 Clinical age : Naegele’s rules : LMP = 280d -3 +7 Post-ovulatory age : 1d 14d 28d Oocyte <24hr |------( -2d ][ +1d)-----14 -----------------| Sperm <48hr ovulation 1wk blastogenesis corona radiate ~ zona pellucida + (1~14d) 2nd mitosis female pronucleus male pronucleus( ) + zygote 2wks 30hr Zygoe 248 3~7d Morula 4~5d Blastocyst germinal 6~7d blastocyst --- blastocele — trophoblast Inner cell mass cyto-tropho-blast Syn-cytio-tropho-blast 1. 2wk 11~12d - Uteroplacental circulation ??? embryonic cell- / Extra-embryonic mesoderm Epiblast hypoblast Secondar = = y/definiti ~somatic~ ve yolk Extra-embryonic amniotic cavity Primary yolk sac sac Splanchnic + trophoblast chorion mesoderm
  2. 2. 3wk 13~14 3 primitive streak ? notochord formation 18d neurulation 20d somites & - / 2 - 3. 2 1. 1. 1. 3 neural groove 2. 2. . fold 3. 3. 3 4th wks> > Neural crest cell>PNS, Neural canal Neural Tube > > neurenteric canal: If > ) : > somite43 (CN12 If Sacro-coccygeal teratoma & > , + ( amniotic cavity) > adrenal( >CNS ( > 31 , ( ( yolk sac ) ) , , etc ) ) 15~56d (3~8wks) Extra: 1. precordal plate oropharyngeal paraxial mesoderm 2. membrane Intermediate mesoderm 3. Lat embryonic 4~8 4~5wk 1. pharyngeal arch = brachial arch by + + 2. pouch by ( primordial pharynx ) 3. groove by 2. 22d - 4wk -critical period 4~8wks * -22~23d , 4wks color doppler 24d – 4wk -- thyroid deverticulum ectoderm mesoderm endoderm **thymus, adrenal - tube canal Surface~ @ CNS PNS CV, , Eg # : & & ./ arch -factor 2,7,9,10 Extra: vit K Parasympathetic-CN 3,7,9,10 lig .n CN5,7,9, 10 1st M - , , ( ) 3 ,V .a - I , .a 2nd S - ,VII .a , , , ( ) rd 57~266d (9~38wks) 3 IX .a .a 4th X IV: .a VI: .a 5th 6th ,X : groove 4 pouch Fetal 1st 1st 2nd 2~4 tonsil 3rd , thymus 4th 3. CV : cephalic folding ( ) heart tube Truncus arteriosus bulbus cordis : conus artriosus : aortic vestibule
  3. 3. ventricle primordial Atrium - - sinus venosus R’t horn ( ), coronary sinus L’t horn ( ), sinus venarum th Partition: 4~7 wks AV valve A-V canal Endocardial cushion atrium ( :R’t to L’t shunt ) Septum premium ostium primum ostium secundum ( ) Septum secundum foramen ovale @ foramen ovale valve ventricle Primodial interventricular septum muscular part of endocardial cushion membranous part of interventricular septum 1. : : portal vein, hepatic sinusoids, hepatic vein vitelline vein yolk sac 2. : Umbilical vein : O2 or ICV 3. 1. a). .a dorsal intersegmental.a b). .a vitelline artery c). .a Umbilical .a 2. Aortic arch: 6 1st .a ext.carotid.a .a maxillary.a 2nd .a stapedial .a O1 -ostium premium 3rd .a S1 -septum primium .a S2 -septum secundum 4th FO -foramen ovale : .a : 5th 6th : , 3. dorsal intersegmental .a X30 4. vitelline .a 5. .a Umbilical .a : 4wks , , , primodial gut : - orapharyngeal membrane - by. a. b. primordial mouth - cloacal membrane - by .a. b. anal pit foregut midgut hindgut 1.primordial pharynx & 12 ( ) 2/3 1/3 , , ( ,,, , , U , = : ) Yalk stalk vitelline duct 2. a. Cranial limbs: , 3. , ,12 ( ) b. caudal limbs: , 3. , , 90 , SMA A. - 6wks- 180 Cloaca uro-rectal septum 10wks- 270 : / , , ( ), urogenital sinus ( ), ( ) 180 , ( ) B. -- hindgut , Cloacal membrane @ 7wks A + B pineal body () - @ from Uro-genital membrane ~ - , 8wk Anal membrane If > ( ) : a. umbilicoileal fistula b.Meckel c. umbilical sinus
  4. 4. > primordial pharynx> & - laryngotracheal diverticulum> - > laryngotracheal tube > bronchial bud Bronchial bud 4w 4w 5w 5w~ 1 pseudogland pronephros ular period terminal meta meso bronchiole nephros nephros 16w 2. ~ = ~ Canalicular Repiratory~- Muellerian duct Wolffian duct period =para- alveolar duct mesonephrons 3. 24 Xby SYY gene by SYYgene Terminal sac alveolar sac , : : , , ~ - BBB -appendix testis , - surfactant -utriculus prostatus : , 32~ 4. .n : 8w alveolar @95% -appendix vesiculosa -epoophoron -Gart her’s duct Urogenital sinus Prostate?,Urinary bladder , Urethra lower vaginal * vaginal : Prostatic utricle ( 2/3) 1/3-para-mesonephric 2/3-urogenital sinus bulbo-urethral gl Greater vestibular gl Genital tubercle/ #Phallus Glans penis Clitoris Corpus spongiosum Bulb of vestibule Corpus cavernosa Corpus cavernosa Urogenital/urethral fold penis(Ventral aspect) Labia minora Genital/labioscrotal swelling scrotum Labia majora Cortex of medulla Rete ovarii Rete testis Gubemaculum testis Ovary lig, Round lig gubermaculum Mesonephric tubules epoophoron Ductuli efferentes Mesonephric duct Duct of epoophoron Duct of Gartner Para-mesonephric Appendix of testis fallopian tube uterus Median umbilical fold .a lig X2 *indomethacin Median umbilical cord/Urachus X Medial umbilical fold Round lig. Obliterated umbilical.a. .a .v PGI2 Lat Inf. Epigastric. Vessels Ductus venous Venous lig Retro-uterine Recto-uterine pouch of Douglas Ductus arteriosus lig ( for recurrent largyngeal.n) PGI2 Bradykinin Foramen ovale Umbilical cord :1.2 ( ) 2.1 ( 3. Urachus- - alantosis( - ) Placenta :1. hCG, hGS,relaxin,estrogen,progesterone ( 8wk HCG,10wk estrogen,progesterone) : 1. decidua basalis 2. chorion frondosum
  5. 5. 1.decidua parietalis 2. capsularis 3. basalis nd 2 wks Primary chorionic villi Chrionic villi cytotrophoblastic core 3rd wks Secondary mesenchyme Tertiary & : 1.Placenta membrane:1.syncytiotrophoblast 2.cytotrophoblast *cytotrophoblastic shell 3.connective tissue of villus 4.endothelium of fetal capillus hermaphroditism=intersexuality: & 70% 46XX & or : 20% 46XX/46 XY(mosaic) 10% 46XY 46XX & Congenital adrenal hyperplasia 46XY & 1. T & MIF 2. = Testicular ferminization syn = androgen insensitivity syndrome(AIS) Trisomy 21 Down syndrome Growth retardation, mental retardation, craniofacial abnormalities Trisomy 18 Mental retardation, , low set ears, flexion of fingers and hand Trisomy 13 Mental retardation, , Cleft lip&palate, deafness, eye defect, polydactyly XXY Klinefelter syndrome ,sterility,testicular atrophy,gyncomastia Extra: X:mental retardation 45X Turner syndrome ovaries(gonadal dysgenesis), XXX Triple X syndrome Scanty menses, mental retardation

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