Fall 2007 Stem Cell Forum

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Introductionof stem cell basics given before debate co-sponsored by Michigan State University's Undergraduate Bioethics Society

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Fall 2007 Stem Cell Forum

  1. 1. Zach Jarou Undergraduate Bioethics Society Michigan State University Wednesday, October 24th, 2007
  2. 2. Meetings are Alternate Tuesdays 7:30pm in 1420 BPS to learn more, visit: www.msu.edu/~ubs or Facebook
  3. 3. About Me   BS Chair U   hysiology major P   esearch experience R   rotein-ligand docking (drug design) P   tem cells S   ioSci Undergrad Lab TA B   lso, Botany Greenhouse Volunteer & A CNS DSAC
  4. 4. Life Exists at Many Levels • atoms ==> molecules ==> macromolecules ==> • organelles ==> cells ==> tissues ==> • organs ==> systems ==> • organisms ==> populations ==> communities ==> • ecosystems ==> biomes ==> biosphere but where does “life” begin?
  5. 5. Cellular Basis of Humans   10 trillion cells ~ in human body   00+ distinct 2 cell types   tructure ==> s where do all of these unique cells come from? function
  6. 6. Basics of Stem Cells
  7. 7. Scientific/Medical Benefits   eplace damaged cells/tissues/organs r   eta-pancreatic cells (type I diabetes) b   opamine secreting neurons (Parkinsons) d   pinal cord (paralysis) s   yelin sheaths (multiple sclerosis) m   ornea (blindness) C   nderstanding basis of cell development u could prevent birth defects   rug testing/development d
  8. 8. But, Not all Stem Cells are Created Equal   otency P   mbryonic = pluripotent e   dult = multipotent a   ifespan L   mbryonic = divide & grow indefinitely e   dult = limited a
  9. 9. Embryonic Stem Cells   uring in vitro fertilization, D egg + sperm + petri dish + 5 days ==> blastocyst   hollow ball of 70-100 cells (smaller than grain of sand), inner cell mass can be harvested   f implanted into i uterus…
  10. 10. …it will become a fetus   efined as fetus after D 8 weeks   ide note: neural s activity/heart beat does not begin until the 6th week of development
  11. 11. Adult Stem Cells   ene deactivation g ==> less potentcy   issue-specific; t within bone marrow:   ematopoietic ==> h blood cells   esenchymal ==> m bone, fat, cartilage, muscle
  12. 12. Cloning (Nuclear Transfer)   ucleus of adult body cell used to replace n egg cell nucleus, creating genetically compatible embyronic stem cells   herapeutic - blastocyst used as stem cell t source, immunosupressive drugs not required for transplant   eproductive - blastocyst implanted into fetus r
  13. 13. My Personal Views   on’t consider harvesting ESCs from d blastocyst to be taking life   ouble-edge sword d   ducated people ==> intelligent policy e   merica is losing to the competition A   ong-term consequences to sustainability l

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